ID   C5D1R4_VARPS            Unreviewed;       476 AA.
AC   C5D1R4;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 67.
DE   SubName: Full=Aldehyde Dehydrogenase {ECO:0000313|EMBL:ACS22834.1};
GN   OrderedLocusNames=Vapar_6271 {ECO:0000313|EMBL:ACS22834.1};
OS   Variovorax paradoxus (strain S110).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Variovorax.
OX   NCBI_TaxID=543728 {ECO:0000313|EMBL:ACS22834.1};
RN   [1] {ECO:0000313|EMBL:ACS22834.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=S110 {ECO:0000313|EMBL:ACS22834.1};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA   Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Orwin P.,
RA   Leadbetter J.R., Spain J.C., Han J.I.;
RT   "Complete sequence of chromosome 2 of Variovorax paradoxus S110.";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH;
CC         Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=1.2.1.3;
CC         Evidence={ECO:0000256|ARBA:ARBA00024149};
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DR   EMBL; CP001636; ACS22834.1; -; Genomic_DNA.
DR   AlphaFoldDB; C5D1R4; -.
DR   STRING; 543728.Vapar_6271; -.
DR   KEGG; vap:Vapar_6271; -.
DR   eggNOG; COG1012; Bacteria.
DR   HOGENOM; CLU_005391_5_3_4; -.
DR   OrthoDB; 6187633at2; -.
DR   GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IEA:UniProt.
DR   GO; GO:0070887; P:cellular response to chemical stimulus; IEA:UniProt.
DR   CDD; cd07138; ALDH_CddD_SSP0762; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   PANTHER; PTHR42804; ALDEHYDE DEHYDROGENASE; 1.
DR   PANTHER; PTHR42804:SF1; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          17..469
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
SQ   SEQUENCE   476 AA;  50080 MW;  F91639A1EEC51EFB CRC64;
     MWNIDQAYID GAFVPVQGSE RLEICNPATE RAIGTVTLAN REDAKRAIAA ANRAQPALAR
     STRAQRIDML RRLEAAVLAR TERIREATIE EYGGPLARSQ WVSNYASQCF ATTAQALRDY
     AFERRLGEAT VVMEPVGVAG LIAPWNAAAG SICSKLASAI AAGCASVVKP SELGPLQAQA
     VTEALHDAGL PPGVFNVLLG RGSDVGDEIA TSAGIAKISF TGSTQTGKLI ARAGVDTMKR
     VSLALSGKSA TLVLDDADLA AALPLALNAA FMNNGQACVA GTRLLIPRAH MKAAIEQVRA
     AAAALRVGDP RDPATAIGPL ASQAQFDRVQ HFIRRGLAQG ATLVAGGEGR PDGFERGWFV
     RPTVFAEVRN DMDIAREEIF GPVLSMIGYG DEDEAIEIAN DSPYGLQAYV FSSDAQRALR
     VASRLRVGTV LVNRIAPELA APFGGVKQSG VGREFGVFGM EAFLEPKTIA AADGIA
//