ID   C5CY69_VARPS            Unreviewed;       512 AA.
AC   C5CY69;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 70.
DE   RecName: Full=aldehyde dehydrogenase (NAD(+)) {ECO:0000256|ARBA:ARBA00024226};
DE            EC=1.2.1.3 {ECO:0000256|ARBA:ARBA00024226};
GN   OrderedLocusNames=Vapar_0310 {ECO:0000313|EMBL:ACS16973.1};
OS   Variovorax paradoxus (strain S110).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Variovorax.
OX   NCBI_TaxID=543728 {ECO:0000313|EMBL:ACS16973.1};
RN   [1] {ECO:0000313|EMBL:ACS16973.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=S110 {ECO:0000313|EMBL:ACS16973.1};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA   Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Orwin P.,
RA   Leadbetter J.R., Spain J.C., Han J.I.;
RT   "Complete sequence of chromosome 1 of Variovorax paradoxus S110.";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
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DR   EMBL; CP001635; ACS16973.1; -; Genomic_DNA.
DR   AlphaFoldDB; C5CY69; -.
DR   STRING; 543728.Vapar_0310; -.
DR   KEGG; vap:Vapar_0310; -.
DR   eggNOG; COG1012; Bacteria.
DR   HOGENOM; CLU_005391_1_2_4; -.
DR   OrthoDB; 6187633at2; -.
DR   GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0043878; F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity; IEA:UniProtKB-EC.
DR   CDD; cd07130; ALDH_F7_AASADH; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR044638; ALDH7A1-like.
DR   PANTHER; PTHR43521; ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE; 1.
DR   PANTHER; PTHR43521:SF1; ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003345}.
FT   DOMAIN          31..489
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        264
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   512 AA;  54017 MW;  558660CEC8F96F2B CRC64;
     MPEAQAFLSV ATEIAQLLQR LGVPGAAHTG GELTVRSPVT GEVVAQVRQT TAAEAAAAIG
     QAHEAFKAWR SVPAPRRGEL VRLLGEELRA AKADLGRLVT LEAGKIPSEG AGEVQEMIDI
     CDFAVGLSRQ LYGLTLATER AEHRMMETWH PLGVCGVISA FNFPVAVWSW NAALALVCGD
     SVVWKPSEKT PLTALAVHAI AQRALARFGD APEGLLGLLL GQRDIGEVLV DDHRVPILSA
     TGSTAMGRQV GPKLAARFAR AILELGGNNA AIVTPSADLD LTLRAIAFSA MGTAGQRCTT
     LRRLFVHDSV YDALVPKLAK VYGNVQVGDP REAGTLVGPL IDRAAFDGMQ KALGESREIG
     ATVHGGQRVE GIGTKDAFYV RPALVELKSH DGPVLRETFA PILYVVRYSA LDDAIEWHNA
     VGAGLSSSIF TLNVREAERF LSSAGSDCGI ANVNIGPSGA EIGGAFGGEK ETGGGREAGS
     DSWKAYMRRA TNTINYSTAL PLAQGVTFEI ND
//