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C5CX88

- ALR_VARPS

UniProt

C5CX88 - ALR_VARPS

Protein

Alanine racemase

Gene

alr

Organism
Variovorax paradoxus (strain S110)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei35 – 351Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei130 – 1301SubstrateUniRule annotation
    Active sitei254 – 2541Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei302 – 3021Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciVPAR543728:GHLL-230-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alr
    Ordered Locus Names:Vapar_0229
    OrganismiVariovorax paradoxus (strain S110)
    Taxonomic identifieri543728 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeVariovorax
    ProteomesiUP000000453: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 366366Alanine racemasePRO_1000213844Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei35 – 351N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi543728.Vapar_0229.

    Structurei

    3D structure databases

    ProteinModelPortaliC5CX88.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    HOGENOMiHOG000031446.
    KOiK01775.
    OMAiYGHGLER.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C5CX88-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRPILATVH TAALRHNLDR ARRAAVDARV WAVVKANAYG HGIERVYEGL    50
    RGADGFALLD LAEAERVRAL GWRGPVLLLE GVFDARDLEL CSRLDLWHTV 100
    HCDEQIDMLA AHKTLKPQRV FLKMNSGMNR LGFAPERFGS AWTRLNALPQ 150
    VDEISLMTHF SDADGARGIA HQLEVFERAT HDLLGERSIA NSAATLRHAR 200
    QTRGDWVRPG IVLYGSAPDF PEHDAAHWQL QPTMTLSTKL IGIQTLKAGD 250
    TIGYGSNFTA EGPLTIGVAA VGYADGYPRH CNTGTPVLVN GVRTRMVGRV 300
    SMDMITVDLT PVPEAKFGTE VTLWGRSAVS GAVLPIDEVA QAAGTVGYEL 350
    MCAVAPRVPF APADGE 366
    Length:366
    Mass (Da):39,753
    Last modified:July 28, 2009 - v1
    Checksum:i0A84A67B8C529443
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001635 Genomic DNA. Translation: ACS16892.1.
    RefSeqiWP_012745393.1. NC_012791.1.
    YP_002942158.1. NC_012791.1.

    Genome annotation databases

    EnsemblBacteriaiACS16892; ACS16892; Vapar_0229.
    GeneIDi7971438.
    KEGGivap:Vapar_0229.
    PATRICi24000844. VBIVarPar36677_0236.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001635 Genomic DNA. Translation: ACS16892.1 .
    RefSeqi WP_012745393.1. NC_012791.1.
    YP_002942158.1. NC_012791.1.

    3D structure databases

    ProteinModelPortali C5CX88.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 543728.Vapar_0229.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACS16892 ; ACS16892 ; Vapar_0229 .
    GeneIDi 7971438.
    KEGGi vap:Vapar_0229.
    PATRICi 24000844. VBIVarPar36677_0236.

    Phylogenomic databases

    eggNOGi COG0787.
    HOGENOMi HOG000031446.
    KOi K01775.
    OMAi YGHGLER.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci VPAR543728:GHLL-230-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the metabolically versatile plant growth-promoting endophyte, Variovorax paradoxus S110."
      Han J.I., Choi H.K., Lee S.W., Orwin P.M., Kim J., Laroe S.L., Kim T.G., O'Neil J., Leadbetter J.R., Lee S.Y., Hur C.G., Spain J.C., Ovchinnikova G., Goodwin L., Han C.
      J. Bacteriol. 193:1183-1190(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: S110.

    Entry informationi

    Entry nameiALR_VARPS
    AccessioniPrimary (citable) accession number: C5CX88
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3