C5CWV0PANC_VARPSPantothenate synthetasePS6.3.2.1Pantoate--beta-alanine ligasePantoate-activating enzymepanCVapar_4094Variovorax paradoxus (strain S110)BacteriaPseudomonadotaBetaproteobacteriaBurkholderialesComamonadaceaeVariovoraxComplete genome sequence of the metabolically versatile plant growth-promoting endophyte, Variovorax paradoxus S110.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.Homodimer.CytoplasmThe reaction proceeds by a bi uni uni bi ping pong mechanism.Belongs to the pantothenate synthetase family.ATP-bindingCytoplasmLigaseNucleotide-bindingPantothenate biosynthesisATP(R)-pantoatebeta-alanineATP(R)-pantoateATPMYIAHTIDELRSHLAAFRRPAFVPTMGNLHEGHLALVKQAKPLGDVTVASIFVNRLQFLPHEDFDTYPRTWDSDCEKLRTAGCGVLFAPDEKALYPEPQTCKVHPDPALADILEGHFRPGFFVGVCTVVMKLFQCVQPRVAVFGKKDYQQLMMIRHMVRQFALPIEIVGSETFRADDGLALSSRNGYLSEAERAEAVQLSKALKAMAQAVQAGERDLAAIEARAMQALAQRGWQPDYLVLRRRSDLQAPSSANLAGEPLVALAAARLGGTRLIDNLEIDAMPS
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