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Protein

Superoxide dismutase [Cu-Zn]

Gene

Vapar_3711

Organism
Variovorax paradoxus (strain S110)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Cu cationUniRule annotationNote: Binds 1 copper ion per subunit.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

CopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

BioCyciVPAR543728:GHLL-3743-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Vapar_3711Imported
OrganismiVariovorax paradoxus (strain S110)Imported
Taxonomic identifieri543728 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeVariovorax
ProteomesiUP000000453 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434 PotentialImportedAdd
BLAST
Chaini35 – 180146 PotentialImportedPRO_5000469374Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi543728.Vapar_3711.

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Keywords - Domaini

SignalImported

Phylogenomic databases

eggNOGiCOG2032.
HOGENOMiHOG000263448.
KOiK04565.
OMAiTIVDKQI.
OrthoDBiEOG6K13RS.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C5CUB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHRLLAATG TALLASALLS ACGSMMGGKP SAAAELMPTA AISPNPTRGT
60 70 80 90 100
VIFTALDHGV RVAGEVRGLA PGSEHGFHIH EKGDCGDNGN ASGGHFNPAG
110 120 130 140 150
GTHGKFSAPG SHAGELPSLV ADGSGVARFS VDVHSISLAE GTANNVVGRA
160 170 180
LVVHRDRDDF TTQPAGNSGP RTACAVIARR
Length:180
Mass (Da):18,063
Last modified:July 28, 2009 - v1
Checksum:iD54FB5B5B9CE62F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001635 Genomic DNA. Translation: ACS20327.1.
RefSeqiYP_002945593.1. NC_012791.1.

Genome annotation databases

EnsemblBacteriaiACS20327; ACS20327; Vapar_3711.
KEGGivap:Vapar_3711.
PATRICi24007885. VBIVarPar36677_3728.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001635 Genomic DNA. Translation: ACS20327.1.
RefSeqiYP_002945593.1. NC_012791.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi543728.Vapar_3711.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACS20327; ACS20327; Vapar_3711.
KEGGivap:Vapar_3711.
PATRICi24007885. VBIVarPar36677_3728.

Phylogenomic databases

eggNOGiCOG2032.
HOGENOMiHOG000263448.
KOiK04565.
OMAiTIVDKQI.
OrthoDBiEOG6K13RS.

Enzyme and pathway databases

BioCyciVPAR543728:GHLL-3743-MONOMER.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the metabolically versatile plant growth-promoting endophyte, Variovorax paradoxus S110."
    Han J.I., Choi H.K., Lee S.W., Orwin P.M., Kim J., Laroe S.L., Kim T.G., O'Neil J., Leadbetter J.R., Lee S.Y., Hur C.G., Spain J.C., Ovchinnikova G., Goodwin L., Han C.
    J. Bacteriol. 193:1183-1190(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S110Imported.

Entry informationi

Entry nameiC5CUB4_VARPS
AccessioniPrimary (citable) accession number: C5CUB4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: April 1, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.