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C5CRW8 (GCSP_VARPS) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Vapar_3301
OrganismVariovorax paradoxus (strain S110) [Complete proteome] [HAMAP]
Taxonomic identifier543728 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeVariovorax

Protein attributes

Sequence length968 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 968968Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000212658

Amino acid modifications

Modified residue7131N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
C5CRW8 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 8DFF68ABC656715D

FASTA968104,204
        10         20         30         40         50         60 
MPIPALPSLQ QLENAEEFLA RHIGIDAADE ARMLPVIGSE TRAELIDGIV PAAIRRAKPM 

        70         80         90        100        110        120 
RLPAPATEAD ALAELKAIAA KNKVFRSFIG QGYYGTHTPG VILRNVLENP AWYTAYTPYQ 

       130        140        150        160        170        180 
AEISQGRMEA LLNFQTMVCD LTGMAIANAS MLDEATAAAE AMTLAKRSVK SKSNVFLVSG 

       190        200        210        220        230        240 
DCHPQTIEVI KTRAAPLGIE VKVSTVSETL PHLMVSGEFF GVLAQYPATT GHVHDLRPLA 

       250        260        270        280        290        300 
GHAHQCDAAF CVAADLLALT LLAPPGEWDA DIVCGTTQRF GMPMCNGGPH AAYLACRDEF 

       310        320        330        340        350        360 
KRSLPGRLVG VSVDTHGQPA YRLALQTREQ HIRREKATSN ICTAQVLPAV VASMYAVYHG 

       370        380        390        400        410        420 
PDGLTRIAQR VAALTAILAQ GLAQMGREPV NGTAFDSLTI RTGDDTPKII ERAQAAGVNL 

       430        440        450        460        470        480 
RQRLQQHLGI SLDETTTRAD IETLWALFVP AGTPMPRFDD LANAVPRLPE DLRRTSAFLT 

       490        500        510        520        530        540 
HPVFNTHKSE TAMLRYIRSL SDKDLALDRS MIPLGSCTMK LNATSEMIPI TWPEFANIHP 

       550        560        570        580        590        600 
FAPAEQLVGY AQLDAQLRAW LCEATGYAGI SLQPNAGSQG EYAGLLAIRS FHEANGQGHR 

       610        620        630        640        650        660 
NICLIPSSAH GTNPASAQMV GLQVVVTACD AQGNVDMDDL RRACEKHSDK LAAVMITYPS 

       670        680        690        700        710        720 
THGVFETRVK ELCELVHEHG GRVYVDGANM NALVGVAAPG EFGGDVSHLN LHKTFCIPHG 

       730        740        750        760        770        780 
GGGPGVGPVC VVEDLVPYLP GHATAGVASN GVGAVSAAPL GNAAVLPISW MYCRMMGAKG 

       790        800        810        820        830        840 
LQAATEIAIL SANYISARLK DHYPTLYASP NGHVAHECIL DLRPLKDSSG VTAEDVAKRL 

       850        860        870        880        890        900 
IDYGFHAPTL SFPVPGTLMV EPTESEPLAE LDRFIDAMIA IRGEIRRVEE GVWPKDDNPL 

       910        920        930        940        950        960 
KHAPHTAASL MAAEWPHPYS RELGAFPLAE LKLAKYWPPI GRVDNVYGDR NLFCSCVPVG 


DYKETEEA 

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References

[1]"Complete genome sequence of the metabolically versatile plant growth-promoting endophyte, Variovorax paradoxus S110."
Han J.I., Choi H.K., Lee S.W., Orwin P.M., Kim J., Laroe S.L., Kim T.G., O'Neil J., Leadbetter J.R., Lee S.Y., Hur C.G., Spain J.C., Ovchinnikova G., Goodwin L., Han C.
J. Bacteriol. 193:1183-1190(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: S110.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001635 Genomic DNA. Translation: ACS19919.1.
RefSeqYP_002945185.1. NC_012791.1.

3D structure databases

ProteinModelPortalC5CRW8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING543728.Vapar_3301.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACS19919; ACS19919; Vapar_3301.
GeneID7973697.
KEGGvap:Vapar_3301.
PATRIC24007035. VBIVarPar36677_3304.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycVPAR543728:GHLL-3332-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_VARPS
AccessionPrimary (citable) accession number: C5CRW8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: February 19, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families