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Protein

Cobalt-precorrin-5B C(1)-methyltransferase

Gene

cbiD

Organism
Variovorax paradoxus (strain S110)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.UniRule annotation

Catalytic activityi

Cobalt-precorrin-5B + S-adenosyl-L-methionine = cobalt-precorrin-6A + S-adenosyl-L-homocysteine.UniRule annotation

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route).UniRule annotation
Proteins known to be involved in the 10 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. Cobalt-precorrin-5B C(1)-methyltransferase (cbiD)
  7. no protein annotated in this organism
  8. no protein annotated in this organism
  9. no protein annotated in this organism
  10. no protein annotated in this organism
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route), the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processCobalamin biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciVPAR543728:G1GF3-1017-MONOMER
UniPathwayiUPA00148; UER00227

Names & Taxonomyi

Protein namesi
Recommended name:
Cobalt-precorrin-5B C(1)-methyltransferaseUniRule annotation (EC:2.1.1.195UniRule annotation)
Alternative name(s):
Cobalt-precorrin-6A synthaseUniRule annotation
Gene namesi
Name:cbiDUniRule annotation
Ordered Locus Names:Vapar_1021
OrganismiVariovorax paradoxus (strain S110)
Taxonomic identifieri543728 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeVariovorax
Proteomesi
  • UP000000453 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002129471 – 365Cobalt-precorrin-5B C(1)-methyltransferaseAdd BLAST365

Proteomic databases

PRIDEiC5CPF1

Interactioni

Protein-protein interaction databases

STRINGi543728.Vapar_1021

Structurei

3D structure databases

SMRiC5CPF1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CbiD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EE8 Bacteria
COG1903 LUCA
HOGENOMiHOG000009126
KOiK02188
OMAiGGIFHTH
OrthoDBiPOG091H02QJ

Family and domain databases

Gene3Di3.30.2110.10, 1 hit
HAMAPiMF_00787 CbiD, 1 hit
InterProiView protein in InterPro
IPR002748 CbiD
IPR036074 CbiD_sf
PANTHERiPTHR35863 PTHR35863, 1 hit
PfamiView protein in Pfam
PF01888 CbiD, 1 hit
PIRSFiPIRSF026782 CbiD, 1 hit
SUPFAMiSSF111342 SSF111342, 1 hit
TIGRFAMsiTIGR00312 cbiD, 1 hit

Sequencei

Sequence statusi: Complete.

C5CPF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDKGAPRGT RTGFTTGACS AAAARAAVIG LVTGQVPDHV ECLLPNGDLV
60 70 80 90 100
RFAVHDGRVD SASAHAMVIK DAGDDPDCTD KAHLTADVRL LPDLAGQVVL
110 120 130 140 150
AGGTGVGTVT MPGLGLAVGG PAINPVPRRN IEANVRAVGA ALLDEVGLEV
160 170 180 190 200
AISVPQGEEM AKKTLNARLG ILGGISILGT TGIVKPYSTA AYRASVVQGV
210 220 230 240 250
QVAGTLGHGV VVLTTGGRTE KFVMAEMPEL PEPAFVQMGD FLRYAMGAAV
260 270 280 290 300
KAGIRKVVIG GMVGKLTKIA QGETITHAGR AEVDTGLLAD LAAGLGAPPD
310 320 330 340 350
VCDAIRGNET ARYAGERMDA LGLGTAFHTA LAQRVIQTLR TRYPDQFELK
360
VLVCDFEGRK IAEAP
Length:365
Mass (Da):37,543
Last modified:July 28, 2009 - v1
Checksum:i199112D2007184EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001635 Genomic DNA Translation: ACS17672.1
RefSeqiWP_012746170.1, NC_012791.1

Genome annotation databases

EnsemblBacteriaiACS17672; ACS17672; Vapar_1021
KEGGivap:Vapar_1021

Similar proteinsi

Entry informationi

Entry nameiCBID_VARPS
AccessioniPrimary (citable) accession number: C5CPF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: May 23, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health