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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Variovorax paradoxus (strain S110)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei65SubstrateUniRule annotation1
Binding sitei144SubstrateUniRule annotation1
Binding sitei204SubstrateUniRule annotation1
Binding sitei234SubstrateUniRule annotation1
Binding sitei238SubstrateUniRule annotation1
Binding sitei239NADUniRule annotation1
Binding sitei291NADUniRule annotation1
Binding sitei326NADUniRule annotation1
Binding sitei392NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi205 – 207NADUniRule annotation3
Nucleotide bindingi268 – 273NADUniRule annotation6
Nucleotide bindingi347 – 349NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076.

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
Ordered Locus Names:Vapar_4683
OrganismiVariovorax paradoxus (strain S110)
Taxonomic identifieri543728 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeVariovorax
Proteomesi
  • UP000000453 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002120581 – 479AdenosylhomocysteinaseAdd BLAST479

Proteomic databases

PRIDEiC5CM29.

Interactioni

Protein-protein interaction databases

STRINGi543728.Vapar_4683.

Structurei

3D structure databases

ProteinModelPortaliC5CM29.
SMRiC5CM29.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C3E. Bacteria.
COG0499. LUCA.
HOGENOMiHOG000227986.
KOiK01251.
OMAiTGNRDII.
OrthoDBiPOG091H00W2.

Family and domain databases

CDDicd00401. SAHH. 1 hit.
HAMAPiMF_00563. AdoHcyase. 1 hit.
InterProiView protein in InterPro
IPR034373. Adenosylhomocysteinase.
IPR000043. Adenosylhomocysteinase-like.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
PANTHERiPTHR23420. PTHR23420. 1 hit.
PfamiView protein in Pfam
PF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
PIRSFiPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTiView protein in SMART
SM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00936. ahcY. 1 hit.
PROSITEiView protein in PROSITE
PS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

C5CM29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAVLKPTPV STADQAIADL SLAAWGRKEI KIAETEMPGL MAIREEFSKA
60 70 80 90 100
QPLKGARITG SLHMTIQTAV LIETLQALGA TVRWASCNIF STQDHAAAAI
110 120 130 140 150
AAAGTPVFAI KGESLKDYWD YTHAIFDFGP KGSQGEGPNM ILDDGGDATL
160 170 180 190 200
LMHLGQRAEK DLGVLSKPTS EEERILYAAI KAKLAVDPTW YTRKSAEIIG
210 220 230 240 250
VTEETTTGVH RLNEMSAKGT LLFRAINVND SVTKSKFDNL YGCRESLVDG
260 270 280 290 300
IKRATDVMIA GKVACVAGYG DVGKGSAQAL RALSAQVWVT EIDPINALQA
310 320 330 340 350
AMEGYKVVTM EYAADKADIF VTTTGNRDVI RHEHMAAMKD QAIVCNIGHF
360 370 380 390 400
DNEIDVASIE KYEWEEIKPQ VDHITFPDGK KIILLAKGRL VNLGCGTGHP
410 420 430 440 450
SFVMSSSFAN QTIAQIELFT KPDAYQAGKV YVLPKHLDEK VARLHLKKVG
460 470
AMLTELTDEQ AAYIGVSKNG PYKPDTYRY
Length:479
Mass (Da):52,070
Last modified:July 28, 2009 - v1
Checksum:iCDCDCC831C963DA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001635 Genomic DNA. Translation: ACS21288.1.
RefSeqiWP_015867444.1. NC_012791.1.

Genome annotation databases

EnsemblBacteriaiACS21288; ACS21288; Vapar_4683.
KEGGivap:Vapar_4683.

Similar proteinsi

Entry informationi

Entry nameiSAHH_VARPS
AccessioniPrimary (citable) accession number: C5CM29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: October 25, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families