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C5CL84

- PUR9_VARPS

UniProt

C5CL84 - PUR9_VARPS

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, Vapar_4630
Organism
Variovorax paradoxus (strain S110)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciVPAR543728:GHLL-4674-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:Vapar_4630
OrganismiVariovorax paradoxus (strain S110)
Taxonomic identifieri543728 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeVariovorax
ProteomesiUP000000453: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 535535Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000203256Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi543728.Vapar_4630.

Structurei

3D structure databases

ProteinModelPortaliC5CL84.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

C5CL84-1 [UniParc]FASTAAdd to Basket

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MAQTALISVS DKTGILEFAQ ALHALGIKLL STGGTAKLLA DAGLPVTEVA    50
DHTGFPEMLD GRVKTLHPKI HGGLLARRDL PAHVAAIQEH GIDTIDLLVV 100
NLYPFEATVA KAGCTLEDAI ENIDIGGPAM VRSAAKNWKD VGVLTDASQY 150
AVALAELQAG GKLSDKTKFA FSVAAFNRIA DYDGAISDYL SAIDFDASIG 200
QASPTRSMFP AQSNGRFVKV QDLRYGENPH QQAAFYRDLH PAPGSLVSAK 250
QLQGKELSYN NIADADAAWE CVKSFDVPAC VIVKHANPCG VAVGKDAAEA 300
YGKAFKTDPT SAFGGIIAFN RPVDGETAQA IAKQFVEVLM APGYTPEALA 350
VFQATKVKQN VRVLEIALPP GGTTDWDNGR NLMDVKRVGS GLLMQTADNH 400
ELAASDLKVV TKKQPTPEQL QDLLFAWKVA KYVKSNAIVF CAGGMTMGVG 450
AGQMSRLDSA RIASIKAEHA GLSLKGTAVA SDAFFPFRDG LDVVVDAGAS 500
CVIQPGGSMR DQEVIDAADE RGVVMVLSGV RHFRH 535
Length:535
Mass (Da):56,657
Last modified:July 28, 2009 - v1
Checksum:i0D57D3A5850B0924
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001635 Genomic DNA. Translation: ACS21235.1.
RefSeqiYP_002946501.1. NC_012791.1.

Genome annotation databases

EnsemblBacteriaiACS21235; ACS21235; Vapar_4630.
GeneIDi7972840.
KEGGivap:Vapar_4630.
PATRICi24009691. VBIVarPar36677_4620.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001635 Genomic DNA. Translation: ACS21235.1 .
RefSeqi YP_002946501.1. NC_012791.1.

3D structure databases

ProteinModelPortali C5CL84.
ModBasei Search...

Protein-protein interaction databases

STRINGi 543728.Vapar_4630.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS21235 ; ACS21235 ; Vapar_4630 .
GeneIDi 7972840.
KEGGi vap:Vapar_4630.
PATRICi 24009691. VBIVarPar36677_4620.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci VPAR543728:GHLL-4674-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the metabolically versatile plant growth-promoting endophyte, Variovorax paradoxus S110."
    Han J.I., Choi H.K., Lee S.W., Orwin P.M., Kim J., Laroe S.L., Kim T.G., O'Neil J., Leadbetter J.R., Lee S.Y., Hur C.G., Spain J.C., Ovchinnikova G., Goodwin L., Han C.
    J. Bacteriol. 193:1183-1190(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S110.

Entry informationi

Entry nameiPUR9_VARPS
AccessioniPrimary (citable) accession number: C5CL84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: May 14, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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