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C5CKX0

- C5CKX0_VARPS

UniProt

C5CKX0 - C5CKX0_VARPS

Protein

Isocitrate dehydrogenase [NADP]

Gene

Vapar_2649

Organism
Variovorax paradoxus (strain S110)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation
    Binds 1 magnesium or manganese ion per subunit By similarity.

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciVPAR543728:GHLL-2676-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:Vapar_2649Imported
    OrganismiVariovorax paradoxus (strain S110)Imported
    Taxonomic identifieri543728 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeVariovorax
    ProteomesiUP000000453: Chromosome 1

    Interactioni

    Protein-protein interaction databases

    STRINGi543728.Vapar_2649.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0538.
    HOGENOMiHOG000021113.
    KOiK00031.
    OMAiCLRPIRY.
    OrthoDBiEOG6SNDTP.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C5CKX0-1 [UniParc]FASTAAdd to Basket

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    MSSYQHIKVP AEGQKITVNA DNSLNVPDQP IIPFIEGDGT GLDITPVMLK    50
    VVDAAVAKAY GGKKKIHWME VYAGEKSTKV YGPDVWLPEE TLHAVRDYVV 100
    SIKGPLTTPV GGGIRSLNVA LRQELDLYVC LRPIQYFEGV PSPVREPHKT 150
    NMVIFRENSE DIYAGIEFEA ESDKAKKLIK FLQDELGVKK IRFPNTSGIG 200
    VKPVSKEGTE RLVRKALQYA VDNDKPSVTI VHKGNIMKFT EGGFRDWAYA 250
    LAAKEFGAEL IDGGPWMKFK NPKTGKEITV KDSIADAFLQ QILLRPAEYS 300
    VIATLNLNGD YVSDALAAQV GGIGIAPGAN LSDTVAMFEA THGTAPKYAG 350
    KDYVNPGSEI LSAEMMLRHM GWTEAADLII SSMEKSIASK KVTYDFARLM 400
    DGATQVSCSG FGQVMIDHM 419
    Length:419
    Mass (Da):45,792
    Last modified:July 28, 2009 - v1
    Checksum:iA2A64D9B40DC3A14
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001635 Genomic DNA. Translation: ACS19274.1.
    RefSeqiYP_002944540.1. NC_012791.1.

    Genome annotation databases

    EnsemblBacteriaiACS19274; ACS19274; Vapar_2649.
    GeneIDi7972411.
    KEGGivap:Vapar_2649.
    PATRICi24005704. VBIVarPar36677_2643.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001635 Genomic DNA. Translation: ACS19274.1 .
    RefSeqi YP_002944540.1. NC_012791.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 543728.Vapar_2649.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACS19274 ; ACS19274 ; Vapar_2649 .
    GeneIDi 7972411.
    KEGGi vap:Vapar_2649.
    PATRICi 24005704. VBIVarPar36677_2643.

    Phylogenomic databases

    eggNOGi COG0538.
    HOGENOMi HOG000021113.
    KOi K00031.
    OMAi CLRPIRY.
    OrthoDBi EOG6SNDTP.

    Enzyme and pathway databases

    BioCyci VPAR543728:GHLL-2676-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the metabolically versatile plant growth-promoting endophyte, Variovorax paradoxus S110."
      Han J.I., Choi H.K., Lee S.W., Orwin P.M., Kim J., Laroe S.L., Kim T.G., O'Neil J., Leadbetter J.R., Lee S.Y., Hur C.G., Spain J.C., Ovchinnikova G., Goodwin L., Han C.
      J. Bacteriol. 193:1183-1190(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: S110Imported.

    Entry informationi

    Entry nameiC5CKX0_VARPS
    AccessioniPrimary (citable) accession number: C5CKX0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 28, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3