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C5CKX0 (C5CKX0_VARPS) Unreviewed, UniProtKB/TrEMBL

Last modified November 13, 2013. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] RuleBase RU004446

EC=1.1.1.42 RuleBase RU004446
Gene names
Ordered Locus Names:Vapar_2649 EMBL ACS19274.1
OrganismVariovorax paradoxus (strain S110) [Complete proteome] [HAMAP]
Taxonomic identifier543728 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeVariovorax

Protein attributes

Sequence length419 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. RuleBase RU004443

Sequences

Sequence LengthMass (Da)Tools
C5CKX0 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: A2A64D9B40DC3A14

FASTA41945,792
        10         20         30         40         50         60 
MSSYQHIKVP AEGQKITVNA DNSLNVPDQP IIPFIEGDGT GLDITPVMLK VVDAAVAKAY 

        70         80         90        100        110        120 
GGKKKIHWME VYAGEKSTKV YGPDVWLPEE TLHAVRDYVV SIKGPLTTPV GGGIRSLNVA 

       130        140        150        160        170        180 
LRQELDLYVC LRPIQYFEGV PSPVREPHKT NMVIFRENSE DIYAGIEFEA ESDKAKKLIK 

       190        200        210        220        230        240 
FLQDELGVKK IRFPNTSGIG VKPVSKEGTE RLVRKALQYA VDNDKPSVTI VHKGNIMKFT 

       250        260        270        280        290        300 
EGGFRDWAYA LAAKEFGAEL IDGGPWMKFK NPKTGKEITV KDSIADAFLQ QILLRPAEYS 

       310        320        330        340        350        360 
VIATLNLNGD YVSDALAAQV GGIGIAPGAN LSDTVAMFEA THGTAPKYAG KDYVNPGSEI 

       370        380        390        400        410 
LSAEMMLRHM GWTEAADLII SSMEKSIASK KVTYDFARLM DGATQVSCSG FGQVMIDHM 

« Hide

References

[1]"Complete genome sequence of the metabolically versatile plant growth-promoting endophyte, Variovorax paradoxus S110."
Han J.I., Choi H.K., Lee S.W., Orwin P.M., Kim J., Laroe S.L., Kim T.G., O'Neil J., Leadbetter J.R., Lee S.Y., Hur C.G., Spain J.C., Ovchinnikova G., Goodwin L., Han C.
J. Bacteriol. 193:1183-1190(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: S110.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001635 Genomic DNA. Translation: ACS19274.1.
RefSeqYP_002944540.1. NC_012791.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING543728.Vapar_2649.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACS19274; ACS19274; Vapar_2649.
GeneID7972411.
KEGGvap:Vapar_2649.
PATRIC24005704. VBIVarPar36677_2643.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0538.
HOGENOMHOG000021113.
KOK00031.
OMAFRDWGYE.
OrthoDBEOG6SNDTP.
ProtClustDBPRK07006.

Enzyme and pathway databases

BioCycVPAR543728:GHLL-2676-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11835. PTHR11835. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR00183. prok_nadp_idh. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC5CKX0_VARPS
AccessionPrimary (citable) accession number: C5CKX0
Entry history
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: November 13, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)