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C5CKX0

- C5CKX0_VARPS

UniProt

C5CKX0 - C5CKX0_VARPS

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Protein

Isocitrate dehydrogenase [NADP]

Gene

Vapar_2649

Organism
Variovorax paradoxus (strain S110)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciVPAR543728:GHLL-2676-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Vapar_2649Imported
OrganismiVariovorax paradoxus (strain S110)Imported
Taxonomic identifieri543728 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeVariovorax
ProteomesiUP000000453: Chromosome 1

Interactioni

Protein-protein interaction databases

STRINGi543728.Vapar_2649.

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiCLRPIRY.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5CKX0-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MSSYQHIKVP AEGQKITVNA DNSLNVPDQP IIPFIEGDGT GLDITPVMLK
60 70 80 90 100
VVDAAVAKAY GGKKKIHWME VYAGEKSTKV YGPDVWLPEE TLHAVRDYVV
110 120 130 140 150
SIKGPLTTPV GGGIRSLNVA LRQELDLYVC LRPIQYFEGV PSPVREPHKT
160 170 180 190 200
NMVIFRENSE DIYAGIEFEA ESDKAKKLIK FLQDELGVKK IRFPNTSGIG
210 220 230 240 250
VKPVSKEGTE RLVRKALQYA VDNDKPSVTI VHKGNIMKFT EGGFRDWAYA
260 270 280 290 300
LAAKEFGAEL IDGGPWMKFK NPKTGKEITV KDSIADAFLQ QILLRPAEYS
310 320 330 340 350
VIATLNLNGD YVSDALAAQV GGIGIAPGAN LSDTVAMFEA THGTAPKYAG
360 370 380 390 400
KDYVNPGSEI LSAEMMLRHM GWTEAADLII SSMEKSIASK KVTYDFARLM
410
DGATQVSCSG FGQVMIDHM
Length:419
Mass (Da):45,792
Last modified:July 28, 2009 - v1
Checksum:iA2A64D9B40DC3A14
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001635 Genomic DNA. Translation: ACS19274.1.
RefSeqiYP_002944540.1. NC_012791.1.

Genome annotation databases

EnsemblBacteriaiACS19274; ACS19274; Vapar_2649.
GeneIDi7972411.
KEGGivap:Vapar_2649.
PATRICi24005704. VBIVarPar36677_2643.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001635 Genomic DNA. Translation: ACS19274.1 .
RefSeqi YP_002944540.1. NC_012791.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 543728.Vapar_2649.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS19274 ; ACS19274 ; Vapar_2649 .
GeneIDi 7972411.
KEGGi vap:Vapar_2649.
PATRICi 24005704. VBIVarPar36677_2643.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000021113.
KOi K00031.
OMAi CLRPIRY.
OrthoDBi EOG6SNDTP.

Enzyme and pathway databases

BioCyci VPAR543728:GHLL-2676-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the metabolically versatile plant growth-promoting endophyte, Variovorax paradoxus S110."
    Han J.I., Choi H.K., Lee S.W., Orwin P.M., Kim J., Laroe S.L., Kim T.G., O'Neil J., Leadbetter J.R., Lee S.Y., Hur C.G., Spain J.C., Ovchinnikova G., Goodwin L., Han C.
    J. Bacteriol. 193:1183-1190(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S110Imported.

Entry informationi

Entry nameiC5CKX0_VARPS
AccessioniPrimary (citable) accession number: C5CKX0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: October 29, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3