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C5CKN8

- COBT_VARPS

UniProt

C5CKN8 - COBT_VARPS

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Protein
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
Gene
cobT, Vapar_2566
Organism
Variovorax paradoxus (strain S110)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB) By similarity.UniRule annotation

Catalytic activityi

Beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei315 – 3151Proton acceptor By similarity

GO - Molecular functioni

  1. cobalamin-transporting ATPase activity Source: UniProtKB-HAMAP
  2. nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cobalamin biosynthetic process Source: UniProtKB-KW
  2. nucleoside biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Cobalamin biosynthesis

Enzyme and pathway databases

BioCyciVPAR543728:GHLL-2591-MONOMER.
UniPathwayiUPA00061; UER00516.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC:2.4.2.21)
Short name:
NN:DBI PRT
Alternative name(s):
N(1)-alpha-phosphoribosyltransferase
Gene namesi
Name:cobT
Ordered Locus Names:Vapar_2566
OrganismiVariovorax paradoxus (strain S110)
Taxonomic identifieri543728 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeVariovorax
ProteomesiUP000000453: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferaseUniRule annotation
PRO_1000204369Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi543728.Vapar_2566.

Family & Domainsi

Sequence similaritiesi

Belongs to the CobT family.

Phylogenomic databases

eggNOGiCOG2038.
HOGENOMiHOG000263500.
KOiK00768.
OMAiYPQAVTG.
OrthoDBiEOG6HF61K.

Family and domain databases

Gene3Di1.10.1610.10. 1 hit.
HAMAPiMF_00230. CobT.
InterProiIPR003200. Nict_dMeBzImd_PRibTrfase-like.
IPR023195. Nict_dMeBzImd_PRibTrfase_N.
IPR017846. Nict_dMeBzImd_PRibTrfase_pro.
[Graphical view]
PfamiPF02277. DBI_PRT. 1 hit.
[Graphical view]
SUPFAMiSSF52733. SSF52733. 1 hit.
TIGRFAMsiTIGR03160. cobT_DBIPRT. 1 hit.

Sequencei

Sequence statusi: Complete.

C5CKN8-1 [UniParc]FASTAAdd to Basket

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MTDSNQTIPS ISDIHDGALA ARLQSALDNK TKPLGALGRL ESLALRIGLV    50
LGSETPVLEA PQMLVCAADH GLAARGVSAF PSDVTWQMVE NFLAGGAAVS 100
VLALQHGLAL TVVDCGVRRD FQARPGLVSR RIAAGTADAS AGPAMTAEQC 150
AQAIANGREV VRALPGNALL LGEMGIGNSS AAALLLARLA GLDIDGCTGS 200
GTGLDAAGLA RKREVLRDVL ALHAAASEPL DALAAFGGFE IATLVGAVLQ 250
AAQERRVIVI DGFIASAAVL VAQALQPHVA QRCVAAHSSA EPGHALLLKH 300
LGLEPLLNLD LRLGEGSGGA LAWPLLESAC RILREMASFE AAGVSRKDS 349
Length:349
Mass (Da):35,615
Last modified:July 28, 2009 - v1
Checksum:i757EB7F4A05D4140
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001635 Genomic DNA. Translation: ACS19192.1.
RefSeqiWP_012747675.1. NC_012791.1.
YP_002944458.1. NC_012791.1.

Genome annotation databases

EnsemblBacteriaiACS19192; ACS19192; Vapar_2566.
GeneIDi7970043.
KEGGivap:Vapar_2566.
PATRICi24005530. VBIVarPar36677_2558.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001635 Genomic DNA. Translation: ACS19192.1 .
RefSeqi WP_012747675.1. NC_012791.1.
YP_002944458.1. NC_012791.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 543728.Vapar_2566.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS19192 ; ACS19192 ; Vapar_2566 .
GeneIDi 7970043.
KEGGi vap:Vapar_2566.
PATRICi 24005530. VBIVarPar36677_2558.

Phylogenomic databases

eggNOGi COG2038.
HOGENOMi HOG000263500.
KOi K00768.
OMAi YPQAVTG.
OrthoDBi EOG6HF61K.

Enzyme and pathway databases

UniPathwayi UPA00061 ; UER00516 .
BioCyci VPAR543728:GHLL-2591-MONOMER.

Family and domain databases

Gene3Di 1.10.1610.10. 1 hit.
HAMAPi MF_00230. CobT.
InterProi IPR003200. Nict_dMeBzImd_PRibTrfase-like.
IPR023195. Nict_dMeBzImd_PRibTrfase_N.
IPR017846. Nict_dMeBzImd_PRibTrfase_pro.
[Graphical view ]
Pfami PF02277. DBI_PRT. 1 hit.
[Graphical view ]
SUPFAMi SSF52733. SSF52733. 1 hit.
TIGRFAMsi TIGR03160. cobT_DBIPRT. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the metabolically versatile plant growth-promoting endophyte, Variovorax paradoxus S110."
    Han J.I., Choi H.K., Lee S.W., Orwin P.M., Kim J., Laroe S.L., Kim T.G., O'Neil J., Leadbetter J.R., Lee S.Y., Hur C.G., Spain J.C., Ovchinnikova G., Goodwin L., Han C.
    J. Bacteriol. 193:1183-1190(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S110.

Entry informationi

Entry nameiCOBT_VARPS
AccessioniPrimary (citable) accession number: C5CKN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: September 3, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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