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C5CKN8

- COBT_VARPS

UniProt

C5CKN8 - COBT_VARPS

Protein

Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Gene

cobT

Organism
Variovorax paradoxus (strain S110)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).UniRule annotation

    Catalytic activityi

    Beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei315 – 3151Proton acceptorUniRule annotation

    GO - Molecular functioni

    1. cobalamin-transporting ATPase activity Source: UniProtKB-HAMAP
    2. nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cobalamin biosynthetic process Source: UniProtKB-KW
    2. nucleoside biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Cobalamin biosynthesis

    Enzyme and pathway databases

    BioCyciVPAR543728:GHLL-2591-MONOMER.
    UniPathwayiUPA00061; UER00516.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferaseUniRule annotation (EC:2.4.2.21UniRule annotation)
    Short name:
    NN:DBI PRTUniRule annotation
    Alternative name(s):
    N(1)-alpha-phosphoribosyltransferaseUniRule annotation
    Gene namesi
    Name:cobTUniRule annotation
    Ordered Locus Names:Vapar_2566
    OrganismiVariovorax paradoxus (strain S110)
    Taxonomic identifieri543728 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeVariovorax
    ProteomesiUP000000453: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 349349Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferasePRO_1000204369Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi543728.Vapar_2566.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CobT family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2038.
    HOGENOMiHOG000263500.
    KOiK00768.
    OMAiYPQAVTG.
    OrthoDBiEOG6HF61K.

    Family and domain databases

    Gene3Di1.10.1610.10. 1 hit.
    HAMAPiMF_00230. CobT.
    InterProiIPR003200. Nict_dMeBzImd_PRibTrfase-like.
    IPR023195. Nict_dMeBzImd_PRibTrfase_N.
    IPR017846. Nict_dMeBzImd_PRibTrfase_pro.
    [Graphical view]
    PfamiPF02277. DBI_PRT. 1 hit.
    [Graphical view]
    SUPFAMiSSF52733. SSF52733. 1 hit.
    TIGRFAMsiTIGR03160. cobT_DBIPRT. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C5CKN8-1 [UniParc]FASTAAdd to Basket

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    MTDSNQTIPS ISDIHDGALA ARLQSALDNK TKPLGALGRL ESLALRIGLV    50
    LGSETPVLEA PQMLVCAADH GLAARGVSAF PSDVTWQMVE NFLAGGAAVS 100
    VLALQHGLAL TVVDCGVRRD FQARPGLVSR RIAAGTADAS AGPAMTAEQC 150
    AQAIANGREV VRALPGNALL LGEMGIGNSS AAALLLARLA GLDIDGCTGS 200
    GTGLDAAGLA RKREVLRDVL ALHAAASEPL DALAAFGGFE IATLVGAVLQ 250
    AAQERRVIVI DGFIASAAVL VAQALQPHVA QRCVAAHSSA EPGHALLLKH 300
    LGLEPLLNLD LRLGEGSGGA LAWPLLESAC RILREMASFE AAGVSRKDS 349
    Length:349
    Mass (Da):35,615
    Last modified:July 28, 2009 - v1
    Checksum:i757EB7F4A05D4140
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001635 Genomic DNA. Translation: ACS19192.1.
    RefSeqiWP_012747675.1. NC_012791.1.
    YP_002944458.1. NC_012791.1.

    Genome annotation databases

    EnsemblBacteriaiACS19192; ACS19192; Vapar_2566.
    GeneIDi7970043.
    KEGGivap:Vapar_2566.
    PATRICi24005530. VBIVarPar36677_2558.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001635 Genomic DNA. Translation: ACS19192.1 .
    RefSeqi WP_012747675.1. NC_012791.1.
    YP_002944458.1. NC_012791.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 543728.Vapar_2566.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACS19192 ; ACS19192 ; Vapar_2566 .
    GeneIDi 7970043.
    KEGGi vap:Vapar_2566.
    PATRICi 24005530. VBIVarPar36677_2558.

    Phylogenomic databases

    eggNOGi COG2038.
    HOGENOMi HOG000263500.
    KOi K00768.
    OMAi YPQAVTG.
    OrthoDBi EOG6HF61K.

    Enzyme and pathway databases

    UniPathwayi UPA00061 ; UER00516 .
    BioCyci VPAR543728:GHLL-2591-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1610.10. 1 hit.
    HAMAPi MF_00230. CobT.
    InterProi IPR003200. Nict_dMeBzImd_PRibTrfase-like.
    IPR023195. Nict_dMeBzImd_PRibTrfase_N.
    IPR017846. Nict_dMeBzImd_PRibTrfase_pro.
    [Graphical view ]
    Pfami PF02277. DBI_PRT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52733. SSF52733. 1 hit.
    TIGRFAMsi TIGR03160. cobT_DBIPRT. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the metabolically versatile plant growth-promoting endophyte, Variovorax paradoxus S110."
      Han J.I., Choi H.K., Lee S.W., Orwin P.M., Kim J., Laroe S.L., Kim T.G., O'Neil J., Leadbetter J.R., Lee S.Y., Hur C.G., Spain J.C., Ovchinnikova G., Goodwin L., Han C.
      J. Bacteriol. 193:1183-1190(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: S110.

    Entry informationi

    Entry nameiCOBT_VARPS
    AccessioniPrimary (citable) accession number: C5CKN8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3