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C5CKN8 (COBT_VARPS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Short name=NN:DBI PRT
EC=2.4.2.21
Alternative name(s):
N(1)-alpha-phosphoribosyltransferase
Gene names
Name:cobT
Ordered Locus Names:Vapar_2566
OrganismVariovorax paradoxus (strain S110) [Complete proteome] [HAMAP]
Taxonomic identifier543728 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeVariovorax

Protein attributes

Sequence length349 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB) By similarity. HAMAP-Rule MF_00230

Catalytic activity

Beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate. HAMAP-Rule MF_00230

Pathway

Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2. HAMAP-Rule MF_00230

Sequence similarities

Belongs to the CobT family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 349349Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase HAMAP-Rule MF_00230
PRO_1000204369

Sites

Active site3151Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
C5CKN8 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 757EB7F4A05D4140

FASTA34935,615
        10         20         30         40         50         60 
MTDSNQTIPS ISDIHDGALA ARLQSALDNK TKPLGALGRL ESLALRIGLV LGSETPVLEA 

        70         80         90        100        110        120 
PQMLVCAADH GLAARGVSAF PSDVTWQMVE NFLAGGAAVS VLALQHGLAL TVVDCGVRRD 

       130        140        150        160        170        180 
FQARPGLVSR RIAAGTADAS AGPAMTAEQC AQAIANGREV VRALPGNALL LGEMGIGNSS 

       190        200        210        220        230        240 
AAALLLARLA GLDIDGCTGS GTGLDAAGLA RKREVLRDVL ALHAAASEPL DALAAFGGFE 

       250        260        270        280        290        300 
IATLVGAVLQ AAQERRVIVI DGFIASAAVL VAQALQPHVA QRCVAAHSSA EPGHALLLKH 

       310        320        330        340 
LGLEPLLNLD LRLGEGSGGA LAWPLLESAC RILREMASFE AAGVSRKDS 

« Hide

References

[1]"Complete genome sequence of the metabolically versatile plant growth-promoting endophyte, Variovorax paradoxus S110."
Han J.I., Choi H.K., Lee S.W., Orwin P.M., Kim J., Laroe S.L., Kim T.G., O'Neil J., Leadbetter J.R., Lee S.Y., Hur C.G., Spain J.C., Ovchinnikova G., Goodwin L., Han C.
J. Bacteriol. 193:1183-1190(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: S110.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001635 Genomic DNA. Translation: ACS19192.1.
RefSeqYP_002944458.1. NC_012791.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING543728.Vapar_2566.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACS19192; ACS19192; Vapar_2566.
GeneID7970043.
KEGGvap:Vapar_2566.
PATRIC24005530. VBIVarPar36677_2558.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2038.
HOGENOMHOG000263500.
KOK00768.
OMAYPQAVTG.
OrthoDBEOG6HF61K.

Enzyme and pathway databases

BioCycVPAR543728:GHLL-2591-MONOMER.
UniPathwayUPA00061; UER00516.

Family and domain databases

Gene3D1.10.1610.10. 1 hit.
HAMAPMF_00230. CobT.
InterProIPR003200. Nict_dMeBzImd_PRibTrfase-like.
IPR023195. Nict_dMeBzImd_PRibTrfase_N.
IPR017846. Nict_dMeBzImd_PRibTrfase_pro.
[Graphical view]
PfamPF02277. DBI_PRT. 1 hit.
[Graphical view]
SUPFAMSSF52733. SSF52733. 1 hit.
TIGRFAMsTIGR03160. cobT_DBIPRT. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCOBT_VARPS
AccessionPrimary (citable) accession number: C5CKN8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: May 14, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways