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C5CJ85

- SYL_VARPS

UniProt

C5CJ85 - SYL_VARPS

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Variovorax paradoxus (strain S110)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei637 – 6371ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciVPAR543728:GHLL-423-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Vapar_0422
    OrganismiVariovorax paradoxus (strain S110)
    Taxonomic identifieri543728 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeVariovorax
    ProteomesiUP000000453: Chromosome 1

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 876876Leucine--tRNA ligasePRO_1000202230Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi543728.Vapar_0422.

    Structurei

    3D structure databases

    ProteinModelPortaliC5CJ85.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi634 – 6385"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C5CJ85-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNPSYKPSDV ESAAQAQWSA ADAYRVTEDA SRKKYYACSM LPYPSGKLHM    50
    GHVRNYTIND MLTRYLRMSG YNVLMPMGWD AFGLPAENAA LKNGVPPAKW 100
    TYENIDYMRG QLQAMGLAID WSREIATCDP SYYKWNQWLF LKMLEKGIAY 150
    RKTQVVNWDP VDQTVLANEQ VIDGKGWRTG ATVERREIPG YYLKISDYAE 200
    ELLEHTQHKL PGWPERVKLM QENWIGKSEG VRFAFTHDIQ DASGRLIQDG 250
    RMYVFTTRAD TIMGVTFCAV APEHPLAAHA ATLDPKVAAF IEECKSGGTT 300
    EAELATQEKK GVPTGLTVKH PITEEQVPVW VGNYVLINYG DGAVMGVPAH 350
    DERDFAFANK YGIEIIQVVL VDDEPHFDYH RWQDWYGDKQ RGVTINSDNF 400
    SGMTHKEAVA AVAHALAQKG LGEMQTTWRL RDWGVSRQRY WGTPIPIIHC 450
    DEHGAVPVPE KDLPVVLPTD CVPDGSGNPL AKHEGFHAGV VCPVCGKPAR 500
    RETDTMDTFV DSSWYFMRYC DPKNEQAMVA EGADYWMPMD QYIGGIEHAI 550
    LHLLYARFWT KVMRDLGLVK VDEPFSKLLT QGMVLNHIYY HRDEKGGKNY 600
    HPPLEVTPTL DAQGRIVGGT TADGTKIEYG GVGKMGKSER NGVDPQDLIE 650
    KYGADTARLY TMFTAPPEAT LEWNDAAVEG SYRFLRRVWN FGVAQADVAP 700
    VAFGGQAFGK AAQALRREVH TVLRQVDYDY QRMQYNTVVS GAMKLLNALE 750
    GFKPDGSAGD AAALREGLGI LLRCLYPATP HITHQLWQHL GYDKELGDLL 800
    DAPWPVVDVA ALEQDEIELM LQVNGKLRGA LRVPAGASKA EIEALALSCD 850
    DFVKFAEGAP AKRVIVVPGR LVNVVI 876
    Length:876
    Mass (Da):97,816
    Last modified:July 28, 2009 - v1
    Checksum:i7B7703D418F056CA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001635 Genomic DNA. Translation: ACS17085.1.
    RefSeqiYP_002942351.1. NC_012791.1.

    Genome annotation databases

    EnsemblBacteriaiACS17085; ACS17085; Vapar_0422.
    GeneIDi7970163.
    KEGGivap:Vapar_0422.
    PATRICi24001238. VBIVarPar36677_0433.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001635 Genomic DNA. Translation: ACS17085.1 .
    RefSeqi YP_002942351.1. NC_012791.1.

    3D structure databases

    ProteinModelPortali C5CJ85.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 543728.Vapar_0422.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACS17085 ; ACS17085 ; Vapar_0422 .
    GeneIDi 7970163.
    KEGGi vap:Vapar_0422.
    PATRICi 24001238. VBIVarPar36677_0433.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci VPAR543728:GHLL-423-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the metabolically versatile plant growth-promoting endophyte, Variovorax paradoxus S110."
      Han J.I., Choi H.K., Lee S.W., Orwin P.M., Kim J., Laroe S.L., Kim T.G., O'Neil J., Leadbetter J.R., Lee S.Y., Hur C.G., Spain J.C., Ovchinnikova G., Goodwin L., Han C.
      J. Bacteriol. 193:1183-1190(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: S110.

    Entry informationi

    Entry nameiSYL_VARPS
    AccessioniPrimary (citable) accession number: C5CJ85
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3