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C5CI89

- FTHS_KOSOT

UniProt

C5CI89 - FTHS_KOSOT

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, Kole_2114
Organism
Kosmotoga olearia (strain TBF 19.5.1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciKOLE521045:GHRV-2168-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Kole_2114
OrganismiKosmotoga olearia (strain TBF 19.5.1)
Taxonomic identifieri521045 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeKosmotoga
ProteomesiUP000002382: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligaseUniRule annotationPRO_1000215437Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi521045.Kole_2114.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5CI89-1 [UniParc]FASTAAdd to Basket

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MNDDLAIAQA TKLKPIDEIA EFAGIERKYL KPYGNYIAKV SHRIYEELAQ    50
REDGNLILVT AITPTSAGEG KTTTSIGLSM ALNRLGKKSF VTLREPSIGP 100
VMGIKGGAAG GGYSQVLPME DINLHFTGDI HAVSLAHNLL SAAIDAHLKF 150
DNELEIDSTQ IYWPRAMDMN DRALRKIVVG LGGKANGYPR EDKFIITAAS 200
EIMAILCLAK DLEDLKERVG NIVIAKNKKK EYVLAKDLKV HGAIAALLKD 250
AIDPNLVQTI EGTPAFIHGG PFANIAHGTN SIIATKIALK LSDYVVTEAG 300
FGADLGGEKF LNFVSQVAGF KPSVVVLVAS LRALKLHGGA KKDSITEENL 350
EALEKGFVNL QVHYENLRKF GVPVLTALNV FPTDTDSEKK LFEKLCEKHG 400
IPFGESRVWA KGGKGGEALA REVIKLAETH TSEYHPLYLM DTPIEEKLDI 450
LTREIYRAKG YELSPTAKAK LRSFKKNGFG NAPVIVAKTQ YSISDNPKLL 500
GAPKDYIFNI RDLNLSAGAG FVVAVSGDIM LMPGLGKEFG AQRIDIDKSG 550
KISGLF 556
Length:556
Mass (Da):60,300
Last modified:July 28, 2009 - v1
Checksum:iEC6E752D9ED809E6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001634 Genomic DNA. Translation: ACR80791.1.
RefSeqiYP_002941795.1. NC_012785.1.

Genome annotation databases

EnsemblBacteriaiACR80791; ACR80791; Kole_2114.
GeneIDi7968526.
KEGGikol:Kole_2114.
PATRICi22189612. VBIKosOle109242_2213.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001634 Genomic DNA. Translation: ACR80791.1 .
RefSeqi YP_002941795.1. NC_012785.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 521045.Kole_2114.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACR80791 ; ACR80791 ; Kole_2114 .
GeneIDi 7968526.
KEGGi kol:Kole_2114.
PATRICi 22189612. VBIKosOle109242_2213.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci KOLE521045:GHRV-2168-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Thermotogales bacterium TBF 19.5.1."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Noll K.
    Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TBF 19.5.1.

Entry informationi

Entry nameiFTHS_KOSOT
AccessioniPrimary (citable) accession number: C5CI89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: April 16, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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