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C5CHW9

- ARGB_KOSOT

UniProt

C5CHW9 - ARGB_KOSOT

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Protein

Acetylglutamate kinase

Gene

argB

Organism
Kosmotoga olearia (strain TBF 19.5.1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei27 – 271Transition state stabilizerUniRule annotation
Binding sitei84 – 841SubstrateUniRule annotation
Binding sitei178 – 1781SubstrateUniRule annotation
Sitei237 – 2371Transition state stabilizerUniRule annotation

GO - Molecular functioni

  1. acetylglutamate kinase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciKOLE521045:GHRV-102-MONOMER.
UniPathwayiUPA00068; UER00107.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylglutamate kinaseUniRule annotation (EC:2.7.2.8UniRule annotation)
Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferaseUniRule annotation
NAG kinaseUniRule annotation
Short name:
AGKUniRule annotation
Gene namesi
Name:argBUniRule annotation
Ordered Locus Names:Kole_0096
OrganismiKosmotoga olearia (strain TBF 19.5.1)
Taxonomic identifieri521045 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeKosmotoga
ProteomesiUP000002382: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282Acetylglutamate kinasePRO_1000202564Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi521045.Kole_0096.

Structurei

3D structure databases

ProteinModelPortaliC5CHW9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni62 – 632Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the acetylglutamate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0548.
HOGENOMiHOG000233259.
KOiK00930.
OrthoDBiEOG6T1WVF.

Family and domain databases

Gene3Di3.40.1160.10. 1 hit.
HAMAPiMF_00082_A. ArgB_A.
MF_00082_B. ArgB_B.
InterProiIPR004662. AcgluKinase.
IPR001048. Asp/Glu/Uridylate_kinase.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000728. NAGK. 1 hit.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR00761. argB. 1 hit.

Sequencei

Sequence statusi: Complete.

C5CHW9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKRETVQVLL EALPYIKEFH GKTFVIKFGG SAMKNENAKE AFIKDLVLLK
60 70 80 90 100
YTGINPVIVH GGGSEISSLM NQLGIEPVFK NGYRITDEKT MEIVEMVLVG
110 120 130 140 150
KVNKDIVMNI NLHGGKAIGV CGKDGELLLA EKETKYGDIG YVGKVKKVDT
160 170 180 190 200
TLIKGLLVEG YIPVIAPIGF GEDGTSYNIN ADIVAAEIAK SLEVEKLVLL
210 220 230 240 250
TDVDGVFKDG KLLPILSSKE AEDLIEKNIV KGGMIPKLQC AISAVNSGVK
260 270 280
SVHIINGGVE HALLLEIFSK EGIGTMIKNL EV
Length:282
Mass (Da):30,436
Last modified:July 28, 2009 - v1
Checksum:iC0EB1CF2ACDD0080
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001634 Genomic DNA. Translation: ACR78824.1.
RefSeqiYP_002939828.1. NC_012785.1.

Genome annotation databases

EnsemblBacteriaiACR78824; ACR78824; Kole_0096.
GeneIDi7967514.
KEGGikol:Kole_0096.
PATRICi22185290. VBIKosOle109242_0097.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001634 Genomic DNA. Translation: ACR78824.1 .
RefSeqi YP_002939828.1. NC_012785.1.

3D structure databases

ProteinModelPortali C5CHW9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 521045.Kole_0096.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACR78824 ; ACR78824 ; Kole_0096 .
GeneIDi 7967514.
KEGGi kol:Kole_0096.
PATRICi 22185290. VBIKosOle109242_0097.

Phylogenomic databases

eggNOGi COG0548.
HOGENOMi HOG000233259.
KOi K00930.
OrthoDBi EOG6T1WVF.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00107 .
BioCyci KOLE521045:GHRV-102-MONOMER.

Family and domain databases

Gene3Di 3.40.1160.10. 1 hit.
HAMAPi MF_00082_A. ArgB_A.
MF_00082_B. ArgB_B.
InterProi IPR004662. AcgluKinase.
IPR001048. Asp/Glu/Uridylate_kinase.
[Graphical view ]
Pfami PF00696. AA_kinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000728. NAGK. 1 hit.
SUPFAMi SSF53633. SSF53633. 1 hit.
TIGRFAMsi TIGR00761. argB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Thermotogales bacterium TBF 19.5.1."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Noll K.
    Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TBF 19.5.1.

Entry informationi

Entry nameiARGB_KOSOT
AccessioniPrimary (citable) accession number: C5CHW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: October 29, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3