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Protein

Acetylglutamate kinase

Gene

argB

Organism
Kosmotoga olearia (strain TBF 19.5.1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.UniRule annotation

Catalytic activityi

ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Arginine biosynthesis bifunctional protein ArgJ (argJ)
  2. Acetylglutamate kinase (argB)
  3. N-acetyl-gamma-glutamyl-phosphate reductase (argC)
  4. Acetylornithine aminotransferase (argD)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei27Transition state stabilizerUniRule annotation1
Binding sitei84SubstrateUniRule annotation1
Binding sitei178SubstrateUniRule annotation1
Sitei237Transition state stabilizerUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00068; UER00107.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylglutamate kinaseUniRule annotation (EC:2.7.2.8UniRule annotation)
Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferaseUniRule annotation
NAG kinaseUniRule annotation
Short name:
NAGKUniRule annotation
Gene namesi
Name:argBUniRule annotation
Ordered Locus Names:Kole_0096
OrganismiKosmotoga olearia (strain TBF 19.5.1)
Taxonomic identifieri521045 [NCBI]
Taxonomic lineageiBacteriaThermotogaeKosmotogalesKosmotogaceaeKosmotoga
Proteomesi
  • UP000002382 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002025641 – 282Acetylglutamate kinaseAdd BLAST282

Interactioni

Protein-protein interaction databases

STRINGi521045.Kole_0096.

Structurei

3D structure databases

ProteinModelPortaliC5CHW9.
SMRiC5CHW9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni62 – 63Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the acetylglutamate kinase family. ArgB subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAS. Bacteria.
COG0548. LUCA.
HOGENOMiHOG000233259.
KOiK00930.
OMAiPKTECCI.
OrthoDBiPOG091H063W.

Family and domain databases

HAMAPiMF_00082. ArgB. 1 hit.
InterProiView protein in InterPro
IPR004662. AcgluKinase.
IPR001048. Asp/Glu/Uridylate_kinase.
PfamiView protein in Pfam
PF00696. AA_kinase. 1 hit.
PIRSFiPIRSF000728. NAGK. 1 hit.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR00761. argB. 1 hit.

Sequencei

Sequence statusi: Complete.

C5CHW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRETVQVLL EALPYIKEFH GKTFVIKFGG SAMKNENAKE AFIKDLVLLK
60 70 80 90 100
YTGINPVIVH GGGSEISSLM NQLGIEPVFK NGYRITDEKT MEIVEMVLVG
110 120 130 140 150
KVNKDIVMNI NLHGGKAIGV CGKDGELLLA EKETKYGDIG YVGKVKKVDT
160 170 180 190 200
TLIKGLLVEG YIPVIAPIGF GEDGTSYNIN ADIVAAEIAK SLEVEKLVLL
210 220 230 240 250
TDVDGVFKDG KLLPILSSKE AEDLIEKNIV KGGMIPKLQC AISAVNSGVK
260 270 280
SVHIINGGVE HALLLEIFSK EGIGTMIKNL EV
Length:282
Mass (Da):30,436
Last modified:July 28, 2009 - v1
Checksum:iC0EB1CF2ACDD0080
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001634 Genomic DNA. Translation: ACR78824.1.
RefSeqiWP_012744612.1. NC_012785.1.

Genome annotation databases

EnsemblBacteriaiACR78824; ACR78824; Kole_0096.
KEGGikol:Kole_0096.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiARGB_KOSOT
AccessioniPrimary (citable) accession number: C5CHW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: June 7, 2017
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families