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C5CHW9 (ARGB_KOSOT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetylglutamate kinase

EC=2.7.2.8
Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK
Gene names
Name:argB
Ordered Locus Names:Kole_0096
OrganismKosmotoga olearia (strain TBF 19.5.1) [Complete proteome] [HAMAP]
Taxonomic identifier521045 [NCBI]
Taxonomic lineageBacteriaThermotogaeThermotogalesThermotogaceaeKosmotoga

Protein attributes

Sequence length282 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP-Rule MF_00082

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP-Rule MF_00082

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00082.

Sequence similarities

Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetylglutamate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 282282Acetylglutamate kinase HAMAP-Rule MF_00082
PRO_1000202564

Regions

Region62 – 632Substrate binding By similarity

Sites

Binding site841Substrate By similarity
Binding site1781Substrate By similarity
Site271Transition state stabilizer By similarity
Site2371Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
C5CHW9 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: C0EB1CF2ACDD0080

FASTA28230,436
        10         20         30         40         50         60 
MKRETVQVLL EALPYIKEFH GKTFVIKFGG SAMKNENAKE AFIKDLVLLK YTGINPVIVH 

        70         80         90        100        110        120 
GGGSEISSLM NQLGIEPVFK NGYRITDEKT MEIVEMVLVG KVNKDIVMNI NLHGGKAIGV 

       130        140        150        160        170        180 
CGKDGELLLA EKETKYGDIG YVGKVKKVDT TLIKGLLVEG YIPVIAPIGF GEDGTSYNIN 

       190        200        210        220        230        240 
ADIVAAEIAK SLEVEKLVLL TDVDGVFKDG KLLPILSSKE AEDLIEKNIV KGGMIPKLQC 

       250        260        270        280 
AISAVNSGVK SVHIINGGVE HALLLEIFSK EGIGTMIKNL EV 

« Hide

References

[1]"Complete sequence of Thermotogales bacterium TBF 19.5.1."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Noll K.
Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TBF 19.5.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001634 Genomic DNA. Translation: ACR78824.1.
RefSeqYP_002939828.1. NC_012785.1.

3D structure databases

ProteinModelPortalC5CHW9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING521045.Kole_0096.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACR78824; ACR78824; Kole_0096.
GeneID7967514.
KEGGkol:Kole_0096.
PATRIC22185290. VBIKosOle109242_0097.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0548.
HOGENOMHOG000233259.
KOK00930.
OrthoDBEOG6T1WVF.

Enzyme and pathway databases

BioCycKOLE521045:GHRV-102-MONOMER.
UniPathwayUPA00068; UER00107.

Family and domain databases

Gene3D3.40.1160.10. 1 hit.
HAMAPMF_00082_A. ArgB_A.
MF_00082_B. ArgB_B.
InterProIPR004662. AcgluKinase.
IPR001048. Asp/Glu/Uridylate_kinase.
[Graphical view]
PfamPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFPIRSF000728. NAGK. 1 hit.
SUPFAMSSF53633. SSF53633. 1 hit.
TIGRFAMsTIGR00761. argB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameARGB_KOSOT
AccessionPrimary (citable) accession number: C5CHW9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: May 14, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways