C5CHW9 (ARGB_KOSOT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate kinase
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Ordered Locus Names:	Kole_0096

Organism

Kosmotoga olearia (strain TBF 19.5.1) [Complete proteome] [HAMAP]

Taxonomic identifier

521045 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Thermotogae › Thermotogae › Thermotogales › Thermotogaceae › Kosmotoga › Kosmotoga olearia

Protein attributes

Sequence length	282 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP-Rule MF_00082
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP-Rule MF_00082
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP acetylglutamate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 282	282	Acetylglutamate kinase HAMAP-Rule MF_00082		PRO_1000202564
Regions
	Region	62 – 63	2	Substrate binding By similarity
Sites
	Binding site	84	1	Substrate By similarity
	Binding site	178	1	Substrate By similarity
	Site	27	1	Transition state stabilizer By similarity
	Site	237	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	C5CHW9 [UniParc]. Last modified July 28, 2009. Version 1. Checksum: C0EB1CF2ACDD0080	FASTA	282	30,436
	10 20 30 40 50 60 MKRETVQVLL EALPYIKEFH GKTFVIKFGG SAMKNENAKE AFIKDLVLLK YTGINPVIVH 70 80 90 100 110 120 GGGSEISSLM NQLGIEPVFK NGYRITDEKT MEIVEMVLVG KVNKDIVMNI NLHGGKAIGV 130 140 150 160 170 180 CGKDGELLLA EKETKYGDIG YVGKVKKVDT TLIKGLLVEG YIPVIAPIGF GEDGTSYNIN 190 200 210 220 230 240 ADIVAAEIAK SLEVEKLVLL TDVDGVFKDG KLLPILSSKE AEDLIEKNIV KGGMIPKLQC 250 260 270 280 AISAVNSGVK SVHIINGGVE HALLLEIFSK EGIGTMIKNL EV

References

[1]

"Complete sequence of Thermotogales bacterium TBF 19.5.1." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Noll K. Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TBF 19.5.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001634 Genomic DNA. Translation: ACR78824.1.
RefSeq	YP_002939828.1. NC_012785.1.
3D structure databases
ProteinModelPortal	C5CHW9.
ModBase	Search...
Protein-protein interaction databases
STRING	521045.Kole_0096.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACR78824; ACR78824; Kole_0096.
GeneID	7967514.
KEGG	kol:Kole_0096.
PATRIC	22185290. VBIKosOle109242_0097.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0548.
HOGENOM	HOG000233259.
KO	K00930.
ProtClustDB	PRK00942.
Enzyme and pathway databases
BioCyc	KOLE521045:GHRV-102-MONOMER.
UniPathway	UPA00068; UER00107.
Family and domain databases
Gene3D	3.40.1160.10. 1 hit.
HAMAP	MF_00082_B. ArgB_B.
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. [Graphical view]
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. argB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_KOSOT

Accession

Primary (citable) accession number: C5CHW9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	July 28, 2009
Last modified:	May 1, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program