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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Kosmotoga olearia (strain TBF 19.5.1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciKOLE521045:GHRV-1975-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:Kole_1924
OrganismiKosmotoga olearia (strain TBF 19.5.1)
Taxonomic identifieri521045 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeKosmotoga
ProteomesiUP000002382 Componenti: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei44 – 6421HelicalUniRule annotationAdd
BLAST
Transmembranei84 – 10421HelicalUniRule annotationAdd
BLAST
Transmembranei111 – 13121HelicalUniRule annotationAdd
BLAST
Transmembranei144 – 16421HelicalUniRule annotationAdd
BLAST
Transmembranei187 – 20721HelicalUniRule annotationAdd
BLAST
Transmembranei212 – 23221HelicalUniRule annotationAdd
BLAST
Transmembranei242 – 26221HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 262262Undecaprenyl-diphosphatasePRO_1000213153Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi521045.Kole_1924.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5CGT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLELWKYTFL GIVQGLTEFL PVSSSGHLTV ISKLMNLNLE TETLKAFFAL
60 70 80 90 100
LHLATFFAVL FFTYKDVWKI ISGVFKKNEQ RTAWKMIALL LFATLPAVVV
110 120 130 140 150
GLGFESQIDK AFSGIVFPAL MLLVTAFFLI LADRFNGNKK ILDLTIYTAL
160 170 180 190 200
MIGLFQAVAI LPGISRSGMT VFAALLFGLS REDSVRFSFL MSLPVTFGAG
210 220 230 240 250
IIELSKVSTE TPYAISGFIA AFFAGIVGLW LLKKFVLHGK LRGFAFYCII
260
VSLIVLSISG GI
Length:262
Mass (Da):28,839
Last modified:July 27, 2009 - v1
Checksum:i2C4C2D689737078F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001634 Genomic DNA. Translation: ACR80605.1.
RefSeqiYP_002941609.1. NC_012785.1.

Genome annotation databases

EnsemblBacteriaiACR80605; ACR80605; Kole_1924.
KEGGikol:Kole_1924.
PATRICi22189210. VBIKosOle109242_2015.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001634 Genomic DNA. Translation: ACR80605.1.
RefSeqiYP_002941609.1. NC_012785.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi521045.Kole_1924.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACR80605; ACR80605; Kole_1924.
KEGGikol:Kole_1924.
PATRICi22189210. VBIKosOle109242_2015.

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OrthoDBiEOG6QP13M.

Enzyme and pathway databases

BioCyciKOLE521045:GHRV-1975-MONOMER.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Thermotogales bacterium TBF 19.5.1."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Noll K.
    Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TBF 19.5.1.

Entry informationi

Entry nameiUPPP_KOSOT
AccessioniPrimary (citable) accession number: C5CGT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2009
Last sequence update: July 27, 2009
Last modified: March 31, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.