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C5CGT6 (UPPP_KOSOT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Kole_1924
OrganismKosmotoga olearia (strain TBF 19.5.1) [Complete proteome] [HAMAP]
Taxonomic identifier521045 [NCBI]
Taxonomic lineageBacteriaThermotogaeThermotogalesThermotogaceaeKosmotoga

Protein attributes

Sequence length262 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 262262Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000213153

Regions

Transmembrane44 – 6421Helical; Potential
Transmembrane84 – 10421Helical; Potential
Transmembrane111 – 13121Helical; Potential
Transmembrane144 – 16421Helical; Potential
Transmembrane187 – 20721Helical; Potential
Transmembrane212 – 23221Helical; Potential
Transmembrane242 – 26221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
C5CGT6 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 2C4C2D689737078F

FASTA26228,839
        10         20         30         40         50         60 
MLELWKYTFL GIVQGLTEFL PVSSSGHLTV ISKLMNLNLE TETLKAFFAL LHLATFFAVL 

        70         80         90        100        110        120 
FFTYKDVWKI ISGVFKKNEQ RTAWKMIALL LFATLPAVVV GLGFESQIDK AFSGIVFPAL 

       130        140        150        160        170        180 
MLLVTAFFLI LADRFNGNKK ILDLTIYTAL MIGLFQAVAI LPGISRSGMT VFAALLFGLS 

       190        200        210        220        230        240 
REDSVRFSFL MSLPVTFGAG IIELSKVSTE TPYAISGFIA AFFAGIVGLW LLKKFVLHGK 

       250        260 
LRGFAFYCII VSLIVLSISG GI 

« Hide

References

[1]"Complete sequence of Thermotogales bacterium TBF 19.5.1."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Noll K.
Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TBF 19.5.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001634 Genomic DNA. Translation: ACR80605.1.
RefSeqYP_002941609.1. NC_012785.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING521045.Kole_1924.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACR80605; ACR80605; Kole_1924.
GeneID7968415.
KEGGkol:Kole_1924.
PATRIC22189210. VBIKosOle109242_2015.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycKOLE521045:GHRV-1975-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_KOSOT
AccessionPrimary (citable) accession number: C5CGT6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: February 19, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families