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C5CGT6

- UPPP_KOSOT

UniProt

C5CGT6 - UPPP_KOSOT

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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Kosmotoga olearia (strain TBF 19.5.1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciKOLE521045:GHRV-1975-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:Kole_1924
OrganismiKosmotoga olearia (strain TBF 19.5.1)
Taxonomic identifieri521045 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeKosmotoga
ProteomesiUP000002382: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 262262Undecaprenyl-diphosphatasePRO_1000213153Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi521045.Kole_1924.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei44 – 6421HelicalUniRule annotationAdd
BLAST
Transmembranei84 – 10421HelicalUniRule annotationAdd
BLAST
Transmembranei111 – 13121HelicalUniRule annotationAdd
BLAST
Transmembranei144 – 16421HelicalUniRule annotationAdd
BLAST
Transmembranei187 – 20721HelicalUniRule annotationAdd
BLAST
Transmembranei212 – 23221HelicalUniRule annotationAdd
BLAST
Transmembranei242 – 26221HelicalUniRule annotationAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5CGT6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLELWKYTFL GIVQGLTEFL PVSSSGHLTV ISKLMNLNLE TETLKAFFAL
60 70 80 90 100
LHLATFFAVL FFTYKDVWKI ISGVFKKNEQ RTAWKMIALL LFATLPAVVV
110 120 130 140 150
GLGFESQIDK AFSGIVFPAL MLLVTAFFLI LADRFNGNKK ILDLTIYTAL
160 170 180 190 200
MIGLFQAVAI LPGISRSGMT VFAALLFGLS REDSVRFSFL MSLPVTFGAG
210 220 230 240 250
IIELSKVSTE TPYAISGFIA AFFAGIVGLW LLKKFVLHGK LRGFAFYCII
260
VSLIVLSISG GI
Length:262
Mass (Da):28,839
Last modified:July 28, 2009 - v1
Checksum:i2C4C2D689737078F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001634 Genomic DNA. Translation: ACR80605.1.
RefSeqiYP_002941609.1. NC_012785.1.

Genome annotation databases

EnsemblBacteriaiACR80605; ACR80605; Kole_1924.
GeneIDi7968415.
KEGGikol:Kole_1924.
PATRICi22189210. VBIKosOle109242_2015.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001634 Genomic DNA. Translation: ACR80605.1 .
RefSeqi YP_002941609.1. NC_012785.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 521045.Kole_1924.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACR80605 ; ACR80605 ; Kole_1924 .
GeneIDi 7968415.
KEGGi kol:Kole_1924.
PATRICi 22189210. VBIKosOle109242_2015.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci KOLE521045:GHRV-1975-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Thermotogales bacterium TBF 19.5.1."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Noll K.
    Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TBF 19.5.1.

Entry informationi

Entry nameiUPPP_KOSOT
AccessioniPrimary (citable) accession number: C5CGT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: October 29, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3