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Protein

Endonuclease V

Gene

nfi

Organism
Kosmotoga olearia (strain TBF 19.5.1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi43MagnesiumUniRule annotation1
Metal bindingi109MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Endonuclease VUniRule annotation (EC:3.1.21.7UniRule annotation)
Alternative name(s):
Deoxyinosine 3'endonucleaseUniRule annotation
Deoxyribonuclease VUniRule annotation
Short name:
DNase VUniRule annotation
Gene namesi
Name:nfiUniRule annotation
Ordered Locus Names:Kole_1869
OrganismiKosmotoga olearia (strain TBF 19.5.1)
Taxonomic identifieri521045 [NCBI]
Taxonomic lineageiBacteriaThermotogaeKosmotogalesKosmotogaceaeKosmotoga
Proteomesi
  • UP000002382 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002129741 – 226Endonuclease VAdd BLAST226

Interactioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei79Interaction with target DNAUniRule annotation1

Protein-protein interaction databases

STRINGi521045.Kole_1869.

Structurei

3D structure databases

ProteinModelPortaliC5CGG9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the endonuclease V family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105Y7X. Bacteria.
COG1515. LUCA.
HOGENOMiHOG000229135.
KOiK05982.
OMAiFQSRQYD.
OrthoDBiPOG091H0CQB.

Family and domain databases

CDDicd06559. Endonuclease_V. 1 hit.
HAMAPiMF_00801. Endonuclease_5. 1 hit.
InterProiIPR007581. Endonuclease-V.
[Graphical view]
PfamiPF04493. Endonuclease_5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5CGG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIRCLHDWN VSLEEAADIQ RTLKGMLSFE FPAKKVSIVA GVDVSFPQKN
60 70 80 90 100
LGLCVIVVMD DTLKVIESVY HTQEVHIPYV SGFLSFREGP IFIETVKKLK
110 120 130 140 150
IVPDLFFFDG QGIAHPRGLG IAAHMGLLLE KPSLGVAKSH LFGSYNEPGR
160 170 180 190 200
NKGDFSYMYN KTGEIIGTVL RTKKNTKPVF VSPGHMMDVD TAMSLTLKYT
210 220
GKYRLPEPTR QAHILTQRLR KNHLLR
Length:226
Mass (Da):25,428
Last modified:July 28, 2009 - v1
Checksum:i68975775ADC6F00C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001634 Genomic DNA. Translation: ACR80550.1.
RefSeqiWP_015869193.1. NC_012785.1.

Genome annotation databases

EnsemblBacteriaiACR80550; ACR80550; Kole_1869.
KEGGikol:Kole_1869.
PATRICi22189100. VBIKosOle109242_1960.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001634 Genomic DNA. Translation: ACR80550.1.
RefSeqiWP_015869193.1. NC_012785.1.

3D structure databases

ProteinModelPortaliC5CGG9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi521045.Kole_1869.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACR80550; ACR80550; Kole_1869.
KEGGikol:Kole_1869.
PATRICi22189100. VBIKosOle109242_1960.

Phylogenomic databases

eggNOGiENOG4105Y7X. Bacteria.
COG1515. LUCA.
HOGENOMiHOG000229135.
KOiK05982.
OMAiFQSRQYD.
OrthoDBiPOG091H0CQB.

Family and domain databases

CDDicd06559. Endonuclease_V. 1 hit.
HAMAPiMF_00801. Endonuclease_5. 1 hit.
InterProiIPR007581. Endonuclease-V.
[Graphical view]
PfamiPF04493. Endonuclease_5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNFI_KOSOT
AccessioniPrimary (citable) accession number: C5CGG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: November 2, 2016
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.