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C5CFD6 (C5CFD6_KOSOT) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Kole_1656 EMBL ACR80345.1
OrganismKosmotoga olearia (strain TBF 19.5.1) [Complete proteome] [HAMAP] EMBL ACR80345.1
Taxonomic identifier521045 [NCBI]
Taxonomic lineageBacteriaThermotogaeThermotogalesThermotogaceaeKosmotoga

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain104 – 299196ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding132 – 18251ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2541Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2661Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2661Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2681Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
C5CFD6 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: EF4787AE64C8BC45

FASTA30534,470
        10         20         30         40         50         60 
MNELRRRITV LYGGLSKERP ISLKSGSNVI NALEKLGYIV DAFDLRADNI TELAKLRDTD 

        70         80         90        100        110        120 
LVFIALHGKF GEDGKIQSLL ELFGIEYIGS DSLVSAICFN KNLTYKLLSN TITMPRWKTI 

       130        140        150        160        170        180 
TSEEELEGWK HFPAVIKPAN EGSSIGVYIC DTFEELQNKT TKVLKEYKTL ILEEYIKGRE 

       190        200        210        220        230        240 
LTISIIEKGG QPVVLPILEL KPKRRFYDYE AKYTAGLTEF IVPAPIDDKL KEEIKKLSKR 

       250        260        270        280        290        300 
IFTALGCRHF ARIDGILKEN QFYFLEVNTI PGLTDLSDLP VSARAAGMGF EELIDLIVKE 


ALKPD 

« Hide

References

[1]"Complete sequence of Thermotogales bacterium TBF 19.5.1."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Noll K.
Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TBF 19.5.1 EMBL ACR80345.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001634 Genomic DNA. Translation: ACR80345.1.
RefSeqYP_002941349.1. NC_012785.1.

3D structure databases

ProteinModelPortalC5CFD6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING521045.Kole_1656.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACR80345; ACR80345; Kole_1656.
GeneID7967895.
KEGGkol:Kole_1656.
PATRIC22188642. VBIKosOle109242_1738.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011592.
KOK01921.
OrthoDBEOG6ND0KB.

Enzyme and pathway databases

BioCycKOLE521045:GHRV-1700-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC5CFD6_KOSOT
AccessionPrimary (citable) accession number: C5CFD6
Entry history
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: February 19, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)