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C5CF44

- GCSPB_KOSOT

UniProt

C5CF44 - GCSPB_KOSOT

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Kosmotoga olearia (strain TBF 19.5.1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciKOLE521045:GHRV-1658-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 2UniRule annotation
    Glycine decarboxylase subunit 2UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
    Gene namesi
    Name:gcvPBUniRule annotation
    Ordered Locus Names:Kole_1619
    OrganismiKosmotoga olearia (strain TBF 19.5.1)
    Taxonomic identifieri521045 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeKosmotoga
    ProteomesiUP000002382: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 483483Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_1000212671Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei267 – 2671N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi521045.Kole_1619.

    Structurei

    3D structure databases

    ProteinModelPortaliC5CF44.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239368.
    KOiK00283.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00713. GcvPB.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C5CF44-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTIFEKSVTG RTGYTLPEEK KDEIRPSDYI PEHLLRKELP GLPECSEIDV    50
    VRHYTELTRK NYSVDNGFYP LGSCTMKYNP KLNEKIAALE GFSLLHPYEP 100
    IEKVQGALEV MYRLQTLLSE ITGMDAFTLQ PAAGAHGELT GMLIVKKYFE 150
    VKGENQRTKV IVPDSAHGTN PASASMAGFQ VVEIKSNDNG IIDLDNLEAA 200
    LDESVAAIML TNPNTLGLFE KDIIKIAEMA HKNGTLLYYD GANLNAIMGK 250
    VRPGDMGFDI VHLNLHKTFS TPHGMGGPGS GPVGVKGHLK EFLPIPVVDL 300
    TDEGYILKTD LSHSIGRIRS FYGNFGVVVK ALAYILMLGK DGLTYASEIA 350
    VLNANYLRTR LSELIPTAYP GLCKHEFVLD GTKLVKEYGI KTLDLAKRML 400
    DYGVHPPTIY FPLIVHEALM IEPTETENKD NLDHFVEVVK KILEEAKKDP 450
    EFVKNAPYNT PIKRLDEVTA SRKPKVRWIP KEQ 483
    Length:483
    Mass (Da):53,757
    Last modified:July 28, 2009 - v1
    Checksum:iB4DF7B8A0FAAA507
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001634 Genomic DNA. Translation: ACR80309.1.
    RefSeqiYP_002941313.1. NC_012785.1.

    Genome annotation databases

    EnsemblBacteriaiACR80309; ACR80309; Kole_1619.
    GeneIDi7967853.
    KEGGikol:Kole_1619.
    PATRICi22188556. VBIKosOle109242_1699.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001634 Genomic DNA. Translation: ACR80309.1 .
    RefSeqi YP_002941313.1. NC_012785.1.

    3D structure databases

    ProteinModelPortali C5CF44.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 521045.Kole_1619.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACR80309 ; ACR80309 ; Kole_1619 .
    GeneIDi 7967853.
    KEGGi kol:Kole_1619.
    PATRICi 22188556. VBIKosOle109242_1699.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239368.
    KOi K00283.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci KOLE521045:GHRV-1658-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00713. GcvPB.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Thermotogales bacterium TBF 19.5.1."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Noll K.
      Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TBF 19.5.1.

    Entry informationi

    Entry nameiGCSPB_KOSOT
    AccessioniPrimary (citable) accession number: C5CF44
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3