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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Kosmotoga olearia (strain TBF 19.5.1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciKOLE521045:G1GF2-1637-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:Kole_1619
OrganismiKosmotoga olearia (strain TBF 19.5.1)
Taxonomic identifieri521045 [NCBI]
Taxonomic lineageiBacteriaThermotogaeKosmotogalesKosmotogaceaeKosmotoga
Proteomesi
  • UP000002382 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002126711 – 483Probable glycine dehydrogenase (decarboxylating) subunit 2Add BLAST483

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei267N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiC5CF44

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi521045.Kole_1619

Structurei

3D structure databases

ProteinModelPortaliC5CF44
SMRiC5CF44
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CBI Bacteria
COG1003 LUCA
HOGENOMiHOG000239368
KOiK00283
OMAiMHINLHK
OrthoDBiPOG091H03O6

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
HAMAPiMF_00713 GcvPB, 1 hit
InterProiView protein in InterPro
IPR023012 GcvPB
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

C5CF44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIFEKSVTG RTGYTLPEEK KDEIRPSDYI PEHLLRKELP GLPECSEIDV
60 70 80 90 100
VRHYTELTRK NYSVDNGFYP LGSCTMKYNP KLNEKIAALE GFSLLHPYEP
110 120 130 140 150
IEKVQGALEV MYRLQTLLSE ITGMDAFTLQ PAAGAHGELT GMLIVKKYFE
160 170 180 190 200
VKGENQRTKV IVPDSAHGTN PASASMAGFQ VVEIKSNDNG IIDLDNLEAA
210 220 230 240 250
LDESVAAIML TNPNTLGLFE KDIIKIAEMA HKNGTLLYYD GANLNAIMGK
260 270 280 290 300
VRPGDMGFDI VHLNLHKTFS TPHGMGGPGS GPVGVKGHLK EFLPIPVVDL
310 320 330 340 350
TDEGYILKTD LSHSIGRIRS FYGNFGVVVK ALAYILMLGK DGLTYASEIA
360 370 380 390 400
VLNANYLRTR LSELIPTAYP GLCKHEFVLD GTKLVKEYGI KTLDLAKRML
410 420 430 440 450
DYGVHPPTIY FPLIVHEALM IEPTETENKD NLDHFVEVVK KILEEAKKDP
460 470 480
EFVKNAPYNT PIKRLDEVTA SRKPKVRWIP KEQ
Length:483
Mass (Da):53,757
Last modified:July 28, 2009 - v1
Checksum:iB4DF7B8A0FAAA507
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001634 Genomic DNA Translation: ACR80309.1
RefSeqiWP_015868954.1, NC_012785.1

Genome annotation databases

EnsemblBacteriaiACR80309; ACR80309; Kole_1619
KEGGikol:Kole_1619

Similar proteinsi

Entry informationi

Entry nameiGCSPB_KOSOT
AccessioniPrimary (citable) accession number: C5CF44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: May 23, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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