Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

C5CF44

- GCSPB_KOSOT

UniProt

C5CF44 - GCSPB_KOSOT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Kosmotoga olearia (strain TBF 19.5.1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciKOLE521045:GHRV-1658-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:Kole_1619
OrganismiKosmotoga olearia (strain TBF 19.5.1)
Taxonomic identifieri521045 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeKosmotoga
ProteomesiUP000002382: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 483483Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_1000212671Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei267 – 2671N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi521045.Kole_1619.

Structurei

3D structure databases

ProteinModelPortaliC5CF44.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

C5CF44-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTIFEKSVTG RTGYTLPEEK KDEIRPSDYI PEHLLRKELP GLPECSEIDV
60 70 80 90 100
VRHYTELTRK NYSVDNGFYP LGSCTMKYNP KLNEKIAALE GFSLLHPYEP
110 120 130 140 150
IEKVQGALEV MYRLQTLLSE ITGMDAFTLQ PAAGAHGELT GMLIVKKYFE
160 170 180 190 200
VKGENQRTKV IVPDSAHGTN PASASMAGFQ VVEIKSNDNG IIDLDNLEAA
210 220 230 240 250
LDESVAAIML TNPNTLGLFE KDIIKIAEMA HKNGTLLYYD GANLNAIMGK
260 270 280 290 300
VRPGDMGFDI VHLNLHKTFS TPHGMGGPGS GPVGVKGHLK EFLPIPVVDL
310 320 330 340 350
TDEGYILKTD LSHSIGRIRS FYGNFGVVVK ALAYILMLGK DGLTYASEIA
360 370 380 390 400
VLNANYLRTR LSELIPTAYP GLCKHEFVLD GTKLVKEYGI KTLDLAKRML
410 420 430 440 450
DYGVHPPTIY FPLIVHEALM IEPTETENKD NLDHFVEVVK KILEEAKKDP
460 470 480
EFVKNAPYNT PIKRLDEVTA SRKPKVRWIP KEQ
Length:483
Mass (Da):53,757
Last modified:July 28, 2009 - v1
Checksum:iB4DF7B8A0FAAA507
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001634 Genomic DNA. Translation: ACR80309.1.
RefSeqiYP_002941313.1. NC_012785.1.

Genome annotation databases

EnsemblBacteriaiACR80309; ACR80309; Kole_1619.
GeneIDi7967853.
KEGGikol:Kole_1619.
PATRICi22188556. VBIKosOle109242_1699.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001634 Genomic DNA. Translation: ACR80309.1 .
RefSeqi YP_002941313.1. NC_012785.1.

3D structure databases

ProteinModelPortali C5CF44.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 521045.Kole_1619.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACR80309 ; ACR80309 ; Kole_1619 .
GeneIDi 7967853.
KEGGi kol:Kole_1619.
PATRICi 22188556. VBIKosOle109242_1699.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci KOLE521045:GHRV-1658-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Thermotogales bacterium TBF 19.5.1."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Noll K.
    Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TBF 19.5.1.

Entry informationi

Entry nameiGCSPB_KOSOT
AccessioniPrimary (citable) accession number: C5CF44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: October 1, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3