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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Kosmotoga olearia (strain TBF 19.5.1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase FolE2 (folE2)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei144May be catalytically importantUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Kole_1468
OrganismiKosmotoga olearia (strain TBF 19.5.1)
Taxonomic identifieri521045 [NCBI]
Taxonomic lineageiBacteriaThermotogaeKosmotogalesKosmotogaceaeKosmotoga
Proteomesi
  • UP000002382 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002153921 – 257GTP cyclohydrolase FolE2Add BLAST257

Interactioni

Protein-protein interaction databases

STRINGi521045.Kole_1468

Structurei

3D structure databases

SMRiC5CEC0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DZA Bacteria
COG1469 LUCA
HOGENOMiHOG000280679
KOiK09007
OMAiHNQRGRG
OrthoDBiPOG091H0MIO

Family and domain databases

HAMAPiMF_01527_B GTP_cyclohydrol_B, 1 hit
InterProiView protein in InterPro
IPR022838 GTP_cyclohydrolase_FolE2
IPR003801 GTP_cyclohydrolase_FolE2/MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit

Sequencei

Sequence statusi: Complete.

C5CEC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDVQSEKDH RNIPINMVGI KGLKYPIIVM DRTNKRQHTI GTFNLFVDLP
60 70 80 90 100
KDFRGTHMSR FVEVLDRHNM KVTPKNMESI LDDMREALKA TVAHVTVDFP
110 120 130 140 150
YFIRKNAPIS GIGSYSSYNC GFISTKNKEF DFILKVEVPV LTVCPCSKEI
160 170 180 190 200
SDRGAHNQRA MVNVQVRMNS LVWIEEIIEM VEDAASAPIF TLLKREDEKF
210 220 230 240 250
ITEVSYDNPR FVEDVSREVV LRFMNDPRIS WYRVEVSSQE SIHNHEAYAC

IEKGKSL
Length:257
Mass (Da):29,720
Last modified:July 28, 2009 - v1
Checksum:i19DC4C0CA2C964F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001634 Genomic DNA Translation: ACR80160.1

Genome annotation databases

EnsemblBacteriaiACR80160; ACR80160; Kole_1468
KEGGikol:Kole_1468

Similar proteinsi

Entry informationi

Entry nameiGCH4_KOSOT
AccessioniPrimary (citable) accession number: C5CEC0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: March 28, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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