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Protein

Gamma-glutamyl phosphate reductase

Gene

proA

Organism
Kosmotoga olearia (strain TBF 19.5.1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.UniRule annotation

Catalytic activityi

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH.UniRule annotation

Pathwayi: L-proline biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamate 5-kinase (proB)
  2. Gamma-glutamyl phosphate reductase (proA)
This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Proline biosynthesis
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00098; UER00360.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamyl phosphate reductaseUniRule annotation (EC:1.2.1.41UniRule annotation)
Short name:
GPRUniRule annotation
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenaseUniRule annotation
Glutamyl-gamma-semialdehyde dehydrogenaseUniRule annotation
Short name:
GSA dehydrogenaseUniRule annotation
Gene namesi
Name:proAUniRule annotation
Ordered Locus Names:Kole_1418
OrganismiKosmotoga olearia (strain TBF 19.5.1)
Taxonomic identifieri521045 [NCBI]
Taxonomic lineageiBacteriaThermotogaeKosmotogalesKosmotogaceaeKosmotoga
Proteomesi
  • UP000002382 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002059991 – 414Gamma-glutamyl phosphate reductaseAdd BLAST414

Interactioni

Protein-protein interaction databases

STRINGi521045.Kole_1418.

Structurei

3D structure databases

ProteinModelPortaliC5CE09.
SMRiC5CE09.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the gamma-glutamyl phosphate reductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C2S. Bacteria.
COG0014. LUCA.
HOGENOMiHOG000246356.
KOiK00147.
OMAiCNAIETL.
OrthoDBiPOG091H00OT.

Family and domain databases

CDDicd07079. ALDH_F18-19_ProA-GPR. 1 hit.
Gene3Di3.40.605.10. 2 hits.
HAMAPiMF_00412. ProA. 1 hit.
InterProiView protein in InterPro
IPR016161. Ald_DH/histidinol_DH.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
IPR000965. GPR_dom.
PfamiView protein in Pfam
PF00171. Aldedh. 2 hits.
PIRSFiPIRSF000151. GPR. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00407. proA. 1 hit.
PROSITEiView protein in PROSITE
PS01223. PROA. 1 hit.

Sequencei

Sequence statusi: Complete.

C5CE09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEELIQKARS VKKASIKLQS VSTVQKNEAL LQIGAALKRK EDAILKANKM
60 70 80 90 100
DVKEARDKGI RDSLIDRLAL NQKRIDDMIQ SCHRVAGLKD PVGEVIASWV
110 120 130 140 150
QSDGLRISKV RVPIGAIGII YESRPNVTVE ASILALKTGN SILLRGGSDA
160 170 180 190 200
FHSNMAIVKA IKEGLSRSSL PVESIEIVES TDRKLVEQML KLREYLSLIV
210 220 230 240 250
PRGSNRLIQY VVENSSIPVL ETGVGNCHIF VDDSADLEKA LEIVDNAKTQ
260 270 280 290 300
RPGTCNAVET LLVHQSIAAA FLPMMADRLS KKGVEIRGCS QTQKFIKVKP
310 320 330 340 350
ATDSDWETEF LDLILAVRVV NSLDEAIAHI QKYSSGHSEA ILTENYFNAK
360 370 380 390 400
KFVENIDAAA VYVNASTRFT DGGQFGFGGE IGISTQRLHA RGPVGLEGLT
410
TYKYVILGDY NVRR
Length:414
Mass (Da):45,486
Last modified:July 28, 2009 - v1
Checksum:iAAEB42869BCD0831
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001634 Genomic DNA. Translation: ACR80111.1.
RefSeqiWP_015868758.1. NC_012785.1.

Genome annotation databases

EnsemblBacteriaiACR80111; ACR80111; Kole_1418.
KEGGikol:Kole_1418.

Similar proteinsi

Entry informationi

Entry nameiPROA_KOSOT
AccessioniPrimary (citable) accession number: C5CE09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: June 7, 2017
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families