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C5CC66 (EFTU_MICLC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Elongation factor Tu

Short name=EF-Tu
Gene names
Name:tuf
Ordered Locus Names:Mlut_17200
OrganismMicrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) (Micrococcus lysodeikticus) [Complete proteome] [HAMAP]
Taxonomic identifier465515 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeMicrococcus

Protein attributes

Sequence length396 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis By similarity. HAMAP-Rule MF_00118

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00118

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00118.

Sequence similarities

Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandGTP-binding
Nucleotide-binding
   Molecular functionElongation factor
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

GTPase activity

Inferred from electronic annotation. Source: InterPro

translation elongation factor activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 396396Elongation factor Tu HAMAP-Rule MF_00118
PRO_1000203016

Regions

Nucleotide binding19 – 268GTP By similarity
Nucleotide binding83 – 875GTP By similarity
Nucleotide binding138 – 1414GTP By similarity

Sequences

Sequence LengthMass (Da)Tools
C5CC66 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: D65F3695EBE20F73

FASTA39643,802
        10         20         30         40         50         60 
MAKAKFERTK PHVNIGTIGH VDHGKTTLTA AISKVLYDKY PDLNEARDFA TIDSAPEERQ 

        70         80         90        100        110        120 
RGITINISHV EYQTEKRHYA HVDAPGHADY IKNMITGAAQ MDGAILVVAA TDGPMAQTRE 

       130        140        150        160        170        180 
HVLLARQVGV PALLVALNKS DMVEDEELLE LVEMEVRELL SSQEFDGDEA PVIRTSGLKA 

       190        200        210        220        230        240 
LEGDPQWVKS VEDLMDAVDE YIPDPVRDKD KPFLMPIEDV FTITGRGTVV TGRAERGTLK 

       250        260        270        280        290        300 
INSEVEIVGI RDVQKTTVTG IEMFHKQLDE AWAGENCGLL LRGLKRDDVE RGQVVVEPGS 

       310        320        330        340        350        360 
ITPHTNFEAN VYILSKDEGG RHNPFYSNYR PQFYFRTTDV TGVITLPEGT EMVMPGDTTE 

       370        380        390 
MSVELIQPIA MEEGLGFAIR EGGRTVGSGR VTKITK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001628 Genomic DNA. Translation: ACS31207.1.
RefSeqYP_002957761.1. NC_012803.1.

3D structure databases

ProteinModelPortalC5CC66.
SMRC5CC66. Positions 2-394.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING465515.Mlut_17200.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACS31207; ACS31207; Mlut_17200.
GeneID7985012.
KEGGmlu:Mlut_17200.
PATRIC22624080. VBIMicLut29563_1659.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0050.
HOGENOMHOG000229290.
KOK02358.
OrthoDBEOG6R5C6X.
ProtClustDBPRK00049.

Enzyme and pathway databases

BioCycMLUT465515:GHH6-1717-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_00118_B. EF_Tu_B.
InterProIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSPR00315. ELONGATNFCT.
SUPFAMSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameEFTU_MICLC
AccessionPrimary (citable) accession number: C5CC66
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: April 16, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families