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C5CC19

- C5CC19_MICLC

UniProt

C5CC19 - C5CC19_MICLC

Protein

Alanine racemase

Gene

Mlut_16720

Organism
Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) (Micrococcus lysodeikticus)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei48 – 481Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei153 – 1531SubstrateUniRule annotation
    Active sitei287 – 2871Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei334 – 3341Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciMLUT465515:GHH6-1669-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:Mlut_16720Imported
    OrganismiMicrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) (Micrococcus lysodeikticus)Imported
    Taxonomic identifieri465515 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeMicrococcus
    ProteomesiUP000000738: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei48 – 481N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi465515.Mlut_16720.

    Structurei

    3D structure databases

    ProteinModelPortaliC5CC19.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    HOGENOMiHOG000031444.
    KOiK01775.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C5CC19-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRADVNPAD TERAVRIDLA AVRHNVGVLR ERIRRPDGSR PLLTAVVKAD    50
    AYGHGAVAVA RAAAAAGADR LGVAHVREAL ALRAAGVPLP VLAWLHTGAT 100
    DFAAAVEAEV TLGVSGWDLD AAADAVRGLR ARGGAGPEAR AVLHLKADTG 150
    LGRHGCTPER WPAFVARAAE LEAAGLVRVE GVFSHLGVAD EPDRAAETTA 200
    QLLRFERMAA EAAETLGHPL LRHLANTPAT LARPDTHLDM VRVGLGLYGL 250
    SPFAEVTAAE LGLRPAMSLV TVLANVKAVP AGQGVSYGFR HVTAEPTTLG 300
    LVPVGYADGV PRVVEGTRVH VGGRTVPVVG RIAMDQFVVD LGPDAADAPG 350
    DAVELFGPAS GIPVEEWAAA AGTINYELVT RIGGRVDRQH VDPTPTQEAR 400
    P 401
    Length:401
    Mass (Da):41,672
    Last modified:July 28, 2009 - v1
    Checksum:i5D9FF6B66708B980
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001628 Genomic DNA. Translation: ACS31160.1.
    RefSeqiYP_002957714.1. NC_012803.1.

    Genome annotation databases

    EnsemblBacteriaiACS31160; ACS31160; Mlut_16720.
    GeneIDi7985923.
    KEGGimlu:Mlut_16720.
    PATRICi22623982. VBIMicLut29563_1610.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001628 Genomic DNA. Translation: ACS31160.1 .
    RefSeqi YP_002957714.1. NC_012803.1.

    3D structure databases

    ProteinModelPortali C5CC19.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 465515.Mlut_16720.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACS31160 ; ACS31160 ; Mlut_16720 .
    GeneIDi 7985923.
    KEGGi mlu:Mlut_16720.
    PATRICi 22623982. VBIMicLut29563_1610.

    Phylogenomic databases

    eggNOGi COG0787.
    HOGENOMi HOG000031444.
    KOi K01775.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci MLUT465515:GHH6-1669-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230Imported.

    Entry informationi

    Entry nameiC5CC19_MICLC
    AccessioniPrimary (citable) accession number: C5CC19
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 28, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3