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Protein

Alanine racemase

Gene

Mlut_16720

Organism
Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) (Micrococcus lysodeikticus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Mlut_16720)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei48Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei153SubstrateUniRule annotation1
Active sitei287Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei334Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciMLUT465515:G1GEW-1659-MONOMER
UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Mlut_16720Imported
OrganismiMicrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) (Micrococcus lysodeikticus)Imported
Taxonomic identifieri465515 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaeMicrococcus
Proteomesi
  • UP000000738 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei48N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiC5CC19

Interactioni

Protein-protein interaction databases

STRINGi465515.MlutN2_010100010679

Structurei

3D structure databases

ProteinModelPortaliC5CC19
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini266 – 391Ala_racemase_CInterPro annotationAdd BLAST126

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000031444
KOiK01775
OMAiWRGPILL
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

C5CC19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRADVNPAD TERAVRIDLA AVRHNVGVLR ERIRRPDGSR PLLTAVVKAD
60 70 80 90 100
AYGHGAVAVA RAAAAAGADR LGVAHVREAL ALRAAGVPLP VLAWLHTGAT
110 120 130 140 150
DFAAAVEAEV TLGVSGWDLD AAADAVRGLR ARGGAGPEAR AVLHLKADTG
160 170 180 190 200
LGRHGCTPER WPAFVARAAE LEAAGLVRVE GVFSHLGVAD EPDRAAETTA
210 220 230 240 250
QLLRFERMAA EAAETLGHPL LRHLANTPAT LARPDTHLDM VRVGLGLYGL
260 270 280 290 300
SPFAEVTAAE LGLRPAMSLV TVLANVKAVP AGQGVSYGFR HVTAEPTTLG
310 320 330 340 350
LVPVGYADGV PRVVEGTRVH VGGRTVPVVG RIAMDQFVVD LGPDAADAPG
360 370 380 390 400
DAVELFGPAS GIPVEEWAAA AGTINYELVT RIGGRVDRQH VDPTPTQEAR

P
Length:401
Mass (Da):41,672
Last modified:July 28, 2009 - v1
Checksum:i5D9FF6B66708B980
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001628 Genomic DNA Translation: ACS31160.1
RefSeqiWP_010080419.1, NZ_CABC01000124.1

Genome annotation databases

EnsemblBacteriaiACS31160; ACS31160; Mlut_16720
GeneIDi7985923
KEGGimlu:Mlut_16720
PATRICifig|465515.4.peg.1610

Similar proteinsi

Entry informationi

Entry nameiC5CC19_MICLC
AccessioniPrimary (citable) accession number: C5CC19
Entry historyiIntegrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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