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C5CBT8 (UPPP_MICLC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Mlut_11800
OrganismMicrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) (Micrococcus lysodeikticus) [Complete proteome] [HAMAP]
Taxonomic identifier465515 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeMicrococcus

Protein attributes

Sequence length277 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 277277Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000213154

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane41 – 6121Helical; Potential
Transmembrane90 – 11021Helical; Potential
Transmembrane114 – 13421Helical; Potential
Transmembrane191 – 21121Helical; Potential
Transmembrane224 – 24421Helical; Potential
Transmembrane255 – 27521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
C5CBT8 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 6989D2EE3A4B66AC

FASTA27729,720
        10         20         30         40         50         60 
MTWIEAIILG LVQGLTEFLP ISSSAHIRIV GEFLPSATDP GAAFTAITQL GTELAVLIYF 

        70         80         90        100        110        120 
WRDITRIIGR WSAAVTGRIP HSDPDARMGW LIIVGSIPIA VLGLLLEDWI DTEFRSLWIT 

       130        140        150        160        170        180 
ATMLIVFGVL LALADRLGRQ TKPLEKLTVR DGVLYGLAQA LALIPGVSRS GGTIAAGLAM 

       190        200        210        220        230        240 
GYTRPAATRY AFLLAVPAVF ASGLYKLYTS LTDPGTQGPY GMGETLVATA VAFVVAYAVI 

       250        260        270 
AWLMRFISTN SYLPFVWYRI LLGGVLFALL GAGVISA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001628 Genomic DNA. Translation: ACS30685.1.
RefSeqYP_002957239.1. NC_012803.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING465515.Mlut_11800.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACS30685; ACS30685; Mlut_11800.
GeneID7986251.
KEGGmlu:Mlut_11800.
PATRIC22622992. VBIMicLut29563_1121.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycMLUT465515:GHH6-1177-MONOMER.
SABIO-RKC5CBT8.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_MICLC
AccessionPrimary (citable) accession number: C5CBT8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: May 14, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families