Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) (Micrococcus lysodeikticus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. Pyruvate kinase (Mlut_11020)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39SubstrateUniRule annotation1
Binding sitei121SubstrateUniRule annotation1
Binding sitei161SubstrateUniRule annotation1
Binding sitei211ATPUniRule annotation1
Binding sitei307ATP; via carbonyl oxygenUniRule annotation1
Binding sitei338ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi367 – 370ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMLUT465515:G1GEW-1128-MONOMER
UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:Mlut_11360
OrganismiMicrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) (Micrococcus lysodeikticus)
Taxonomic identifieri465515 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaeMicrococcus
Proteomesi
  • UP000000738 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002033431 – 415Phosphoglycerate kinaseAdd BLAST415

Proteomic databases

PRIDEiC5CBP5

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi465515.MlutN2_010100001467

Structurei

3D structure databases

ProteinModelPortaliC5CBP5
SMRiC5CBP5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 26Substrate bindingUniRule annotation3
Regioni62 – 65Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZA Bacteria
COG0126 LUCA
HOGENOMiHOG000227107
KOiK00927
OMAiDMIFDIG
OrthoDBiPOG091H00YN

Family and domain databases

Gene3Di3.40.50.1260, 3 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

C5CBP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPASTLNDLL EAGVTGRTVL IRSDLNVPLD GDTVTDDGRI RASLPAIRDL
60 70 80 90 100
AEAGARVIVM AHLGRPKGEP DPAYSLRPVA ARMAELLGAD VALAADVTGD
110 120 130 140 150
DARAQAAALQ DGQVLLLENV RFDARETSKD DAERAALAGE MAALAGEDGA
160 170 180 190 200
YVGDAFGAVH RKHASVFDVA AQLPAYQGPL VAAELEVLTR LTESPEQPYV
210 220 230 240 250
VVLGGSKVSD KLAVIDNLLD KADTLLIGGG MLFTFLKAQG HEVGASLLEE
260 270 280 290 300
DQLDTVRAYL RRSEAGAARI VLPTDIVMAS GFAADAEHEV LAADALTSGA
310 320 330 340 350
HGASAMGLDI GPETARAFAE QIRGAQTVFW NGPMGVFEFP AFAEGTRAVA
360 370 380 390 400
RALTEASAAG GLSVVGGGDS AAAVRTLGFA DDAFGHISTG GGASLEYLEG
410
KELPGVTALA GEGRA
Length:415
Mass (Da):42,606
Last modified:July 28, 2009 - v1
Checksum:i3D655285D4C7A3FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001628 Genomic DNA Translation: ACS30642.1
RefSeqiWP_010078717.1, NZ_CABC01000021.1

Genome annotation databases

EnsemblBacteriaiACS30642; ACS30642; Mlut_11360
GeneIDi7985798
KEGGimlu:Mlut_11360
PATRICifig|465515.4.peg.1078

Similar proteinsi

Entry informationi

Entry nameiPGK_MICLC
AccessioniPrimary (citable) accession number: C5CBP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: May 23, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health