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C5CA60 (SYR_MICLC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:Mlut_08000
OrganismMicrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) (Micrococcus lysodeikticus) [Complete proteome] [HAMAP]
Taxonomic identifier465515 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeMicrococcus

Protein attributes

Sequence length556 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 556556Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_1000203100

Regions

Motif134 – 14411"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
C5CA60 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: EBF7B6E8FDC22088

FASTA55659,998
        10         20         30         40         50         60 
MKPEDLSALL SAVLTDAVDA GDLPAALREG ITPARVKVER PRSREHGDWA TNVALQLGKK 

        70         80         90        100        110        120 
AGMAPRDLAG LVAERLTGKP GIAAVDVAGP GFLNVTLDAA SAGALAREIV EAGPEYGRND 

       130        140        150        160        170        180 
TLAGHTVNME FVSANPTGPL HIGHTRWAAL GDAIARLLRA SGADVTAEYY VNDAGNQMNV 

       190        200        210        220        230        240 
FADSVLARLH GRDVPAGGYP GAYVQELADA VALEHPDVRE LTDEAARPVV REAAYRLQMQ 

       250        260        270        280        290        300 
DIKDTLAAFD VHFDVFTSEQ TLHDSGAIDQ AVQRLREQGH IEDREGAVWL KTTDFGDDKD 

       310        320        330        340        350        360 
RVLIRANGEP TYFAADAAYY LHKRDRGFEE KVYLLGADHH GYVNRLKAIA AAAGDDPATN 

       370        380        390        400        410        420 
IEILIGQLIS VNGAKLSKRA GNIIELKDLV EWLGRDALRY DLARYPADSP LTIDPELLRS 

       430        440        450        460        470        480 
ATNDNPVYYV QYAHARASGA ARTAQAHGVD RSEFDAALLT HATESELLAQ LAEFPAVVAA 

       490        500        510        520        530        540 
AARLREPHRV TRHLEVIAGA YHSWYAACRI VPMPTDDGTP RPVETLNRTR LWLNDATAQV 

       550 
LANGLGLLGV SAPEKM 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001628 Genomic DNA. Translation: ACS30329.1.
RefSeqYP_002956883.1. NC_012803.1.

3D structure databases

ProteinModelPortalC5CA60.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING465515.Mlut_08000.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACS30329; ACS30329; Mlut_08000.
GeneID7984751.
KEGGmlu:Mlut_08000.
PATRIC22622239. VBIMicLut29563_0763.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247214.
KOK01887.
OrthoDBEOG6JB13C.

Enzyme and pathway databases

BioCycMLUT465515:GHH6-798-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_MICLC
AccessionPrimary (citable) accession number: C5CA60
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: May 14, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries