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C5CA60

- SYR_MICLC

UniProt

C5CA60 - SYR_MICLC

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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) (Micrococcus lysodeikticus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

  1. arginine-tRNA ligase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMLUT465515:GHH6-798-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
Alternative name(s):
Arginyl-tRNA synthetaseUniRule annotation
Short name:
ArgRSUniRule annotation
Gene namesi
Name:argSUniRule annotation
Ordered Locus Names:Mlut_08000
OrganismiMicrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) (Micrococcus lysodeikticus)
Taxonomic identifieri465515 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeMicrococcus
ProteomesiUP000000738: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Arginine--tRNA ligasePRO_1000203100Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi465515.Mlut_08000.

Structurei

3D structure databases

ProteinModelPortaliC5CA60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi134 – 14411"HIGH" regionAdd
BLAST

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0018.
HOGENOMiHOG000247214.
KOiK01887.
OrthoDBiEOG6JB13C.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5CA60 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKPEDLSALL SAVLTDAVDA GDLPAALREG ITPARVKVER PRSREHGDWA
60 70 80 90 100
TNVALQLGKK AGMAPRDLAG LVAERLTGKP GIAAVDVAGP GFLNVTLDAA
110 120 130 140 150
SAGALAREIV EAGPEYGRND TLAGHTVNME FVSANPTGPL HIGHTRWAAL
160 170 180 190 200
GDAIARLLRA SGADVTAEYY VNDAGNQMNV FADSVLARLH GRDVPAGGYP
210 220 230 240 250
GAYVQELADA VALEHPDVRE LTDEAARPVV REAAYRLQMQ DIKDTLAAFD
260 270 280 290 300
VHFDVFTSEQ TLHDSGAIDQ AVQRLREQGH IEDREGAVWL KTTDFGDDKD
310 320 330 340 350
RVLIRANGEP TYFAADAAYY LHKRDRGFEE KVYLLGADHH GYVNRLKAIA
360 370 380 390 400
AAAGDDPATN IEILIGQLIS VNGAKLSKRA GNIIELKDLV EWLGRDALRY
410 420 430 440 450
DLARYPADSP LTIDPELLRS ATNDNPVYYV QYAHARASGA ARTAQAHGVD
460 470 480 490 500
RSEFDAALLT HATESELLAQ LAEFPAVVAA AARLREPHRV TRHLEVIAGA
510 520 530 540 550
YHSWYAACRI VPMPTDDGTP RPVETLNRTR LWLNDATAQV LANGLGLLGV

SAPEKM
Length:556
Mass (Da):59,998
Last modified:July 28, 2009 - v1
Checksum:iEBF7B6E8FDC22088
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001628 Genomic DNA. Translation: ACS30329.1.
RefSeqiYP_002956883.1. NC_012803.1.

Genome annotation databases

EnsemblBacteriaiACS30329; ACS30329; Mlut_08000.
GeneIDi7984751.
KEGGimlu:Mlut_08000.
PATRICi22622239. VBIMicLut29563_0763.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001628 Genomic DNA. Translation: ACS30329.1 .
RefSeqi YP_002956883.1. NC_012803.1.

3D structure databases

ProteinModelPortali C5CA60.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 465515.Mlut_08000.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS30329 ; ACS30329 ; Mlut_08000 .
GeneIDi 7984751.
KEGGi mlu:Mlut_08000.
PATRICi 22622239. VBIMicLut29563_0763.

Phylogenomic databases

eggNOGi COG0018.
HOGENOMi HOG000247214.
KOi K01887.
OrthoDBi EOG6JB13C.

Enzyme and pathway databases

BioCyci MLUT465515:GHH6-798-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPi MF_00123. Arg_tRNA_synth.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view ]
PANTHERi PTHR11956. PTHR11956. 1 hit.
Pfami PF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view ]
PRINTSi PR01038. TRNASYNTHARG.
SMARTi SM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsi TIGR00456. argS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230.

Entry informationi

Entry nameiSYR_MICLC
AccessioniPrimary (citable) accession number: C5CA60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: October 29, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3