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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) (Micrococcus lysodeikticus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:Mlut_13630
OrganismiMicrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) (Micrococcus lysodeikticus)
Taxonomic identifieri465515 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaeMicrococcus
Proteomesi
  • UP000000738 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22HelicalUniRule annotationAdd BLAST21
Transmembranei55 – 75HelicalUniRule annotationAdd BLAST21
Transmembranei82 – 102HelicalUniRule annotationAdd BLAST21
Transmembranei120 – 140HelicalUniRule annotationAdd BLAST21
Transmembranei158 – 178HelicalUniRule annotationAdd BLAST21
Transmembranei198 – 218HelicalUniRule annotationAdd BLAST21
Transmembranei237 – 257HelicalUniRule annotationAdd BLAST21
Transmembranei264 – 284HelicalUniRule annotationAdd BLAST21
Transmembranei289 – 309HelicalUniRule annotationAdd BLAST21
Transmembranei345 – 365HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002020731 – 375Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST375

Interactioni

Protein-protein interaction databases

STRINGi465515.MlutN2_010100000302.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275124.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

C5CA33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGLLIGGVL GLVLSAAGTP LFIRFLVKRG YGQFVRDDGP TTHKTKRGTP
60 70 80 90 100
TMGGAVIIGS LVLAYLITHG LLAVLGVDFG GPTASGLILL LLTVGMAFVG
110 120 130 140 150
FVDDFTKITK QRSLGLTPRG KIILQALIGT AFAVLALNFP DERGLTPAST
160 170 180 190 200
AISFARDIPW LDLAFAGPAI GVILFVIWSN LITTATTNAV NLTDGLDGLA
210 220 230 240 250
TGATAMITGA YVLISLFQSS QSCALEGTRG CYEVRDPMDL ALLAAILTGS
260 270 280 290 300
LLGFLWWNTS PAKIFMGDTG SLGLGGALAG FAIFTRTEIL VAVLAGLMVA
310 320 330 340 350
ITLSVIIQVG WFKVSGGKRV FLMAPLQHHF ELKGWAEVTV VVRFWLLSLM
360 370
CVTVGLAIFY GDWLIRQGGL AGVTP
Length:375
Mass (Da):39,431
Last modified:July 28, 2009 - v1
Checksum:i148CE4AF55A4C4AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001628 Genomic DNA. Translation: ACS30868.1.
RefSeqiWP_012750918.1. NC_012803.1.

Genome annotation databases

EnsemblBacteriaiACS30868; ACS30868; Mlut_13630.
GeneIDi7984983.
KEGGimlu:Mlut_13630.
PATRICifig|465515.4.peg.1305.

Similar proteinsi

Entry informationi

Entry nameiMRAY_MICLC
AccessioniPrimary (citable) accession number: C5CA33
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: June 7, 2017
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families