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C5C9U0

- PNP_MICLC

UniProt

C5C9U0 - PNP_MICLC

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, Mlut_07100
Organism
Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) (Micrococcus lysodeikticus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi523 – 5231Magnesium By similarity
Metal bindingi529 – 5291Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciMLUT465515:GHH6-709-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:Mlut_07100
OrganismiMicrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) (Micrococcus lysodeikticus)
Taxonomic identifieri465515 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeMicrococcus
ProteomesiUP000000738: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 753753Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_1000215664Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi465515.Mlut_07100.

Structurei

3D structure databases

ProteinModelPortaliC5C9U0.
SMRiC5C9U0. Positions 5-726.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini589 – 64860KH
Add
BLAST
Domaini660 – 73273S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5C9U0-1 [UniParc]FASTAAdd to Basket

« Hide

MEGPEITFAE AVIDNGSYGK RTVRFETGRL AQQAAGAAMV YLDEETSMLS    50
ATTVGKSPRE GFDFFPLTVD VEERMYASGR IPGSFFRREG RPSTDAILTC 100
RLIDRPLRPA FVKGIRNEVQ VVVTVTSIAP DEIYDTVAIN AASLSTQLSG 150
LPFSGPIGGV RMALMDDGSG ARQWVAFPKH SQLKGAVFNM AVAGRVVGDD 200
VAIMMVEAEA TPDSWTLVKE RGAQAPTEEI VAEGLEAAKP FIRALCEAQA 250
DLVKRAGKDP VDVPVFQDYQ DDAYAAVEKL ATDRLTEIFS IADKQERESA 300
SYAYLLEVLE ELAGEGKDFA ERKGEIAKAY GSLTKQIVRR RILTDQVRID 350
GRGLTDIRKL TAEVEVLPRV HGSAIFERGE TQIMGVTTLN MLKMEQQIDS 400
LSPETAKRYM HHYNFPPYST GETGRVGSPK RREIGHGALA ERALVPVLPA 450
REEFPYAIRQ VSEALSSNGS TSMGSVCAST LSLLNAGVPL RAHVAGIAMG 500
LVSAEVDGQT QYAALTDILG AEDAFGDMDF KVAGTAEFVT AIQLDTKLDG 550
IPASVLASAL TQAREARLHI LSVLNAAIDA PDEMAPTAPR IISVRIPVDK 600
IGAVIGPKGA MINQIQDDTG ADITIEDDGT VLIGATDGAS AEAARSAVNA 650
IANPQVPEVG ERYLGTVVKL TTFGAFVSLT PGKDGLLHVS ELRKLNEGKR 700
VDDVEDVLGV GQKVQVEITK IDDRGKLSLS PVGAESDAVA ETADAIESSQ 750
TEA 753
Length:753
Mass (Da):80,493
Last modified:July 28, 2009 - v1
Checksum:iCEB3A92448CFD330
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001628 Genomic DNA. Translation: ACS30242.1.
RefSeqiWP_010079121.1. NZ_CABC01000046.1.
YP_002956796.1. NC_012803.1.

Genome annotation databases

EnsemblBacteriaiACS30242; ACS30242; Mlut_07100.
GeneIDi7984906.
KEGGimlu:Mlut_07100.
PATRICi22622057. VBIMicLut29563_0673.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001628 Genomic DNA. Translation: ACS30242.1 .
RefSeqi WP_010079121.1. NZ_CABC01000046.1.
YP_002956796.1. NC_012803.1.

3D structure databases

ProteinModelPortali C5C9U0.
SMRi C5C9U0. Positions 5-726.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 465515.Mlut_07100.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS30242 ; ACS30242 ; Mlut_07100 .
GeneIDi 7984906.
KEGGi mlu:Mlut_07100.
PATRICi 22622057. VBIMicLut29563_0673.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci MLUT465515:GHH6-709-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230.

Entry informationi

Entry nameiPNP_MICLC
AccessioniPrimary (citable) accession number: C5C9U0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: September 3, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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