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C5C9U0

- PNP_MICLC

UniProt

C5C9U0 - PNP_MICLC

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) (Micrococcus lysodeikticus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi523 – 5231MagnesiumUniRule annotation
    Metal bindingi529 – 5291MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciMLUT465515:GHH6-709-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:Mlut_07100
    OrganismiMicrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) (Micrococcus lysodeikticus)
    Taxonomic identifieri465515 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeMicrococcus
    ProteomesiUP000000738: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 753753Polyribonucleotide nucleotidyltransferasePRO_1000215664Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi465515.Mlut_07100.

    Structurei

    3D structure databases

    ProteinModelPortaliC5C9U0.
    SMRiC5C9U0. Positions 5-726.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini589 – 64860KHUniRule annotationAdd
    BLAST
    Domaini660 – 73273S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218326.
    KOiK00962.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR014069. pppGpp_PNP.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    TIGR02696. pppGpp_PNP. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C5C9U0-1 [UniParc]FASTAAdd to Basket

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    MEGPEITFAE AVIDNGSYGK RTVRFETGRL AQQAAGAAMV YLDEETSMLS    50
    ATTVGKSPRE GFDFFPLTVD VEERMYASGR IPGSFFRREG RPSTDAILTC 100
    RLIDRPLRPA FVKGIRNEVQ VVVTVTSIAP DEIYDTVAIN AASLSTQLSG 150
    LPFSGPIGGV RMALMDDGSG ARQWVAFPKH SQLKGAVFNM AVAGRVVGDD 200
    VAIMMVEAEA TPDSWTLVKE RGAQAPTEEI VAEGLEAAKP FIRALCEAQA 250
    DLVKRAGKDP VDVPVFQDYQ DDAYAAVEKL ATDRLTEIFS IADKQERESA 300
    SYAYLLEVLE ELAGEGKDFA ERKGEIAKAY GSLTKQIVRR RILTDQVRID 350
    GRGLTDIRKL TAEVEVLPRV HGSAIFERGE TQIMGVTTLN MLKMEQQIDS 400
    LSPETAKRYM HHYNFPPYST GETGRVGSPK RREIGHGALA ERALVPVLPA 450
    REEFPYAIRQ VSEALSSNGS TSMGSVCAST LSLLNAGVPL RAHVAGIAMG 500
    LVSAEVDGQT QYAALTDILG AEDAFGDMDF KVAGTAEFVT AIQLDTKLDG 550
    IPASVLASAL TQAREARLHI LSVLNAAIDA PDEMAPTAPR IISVRIPVDK 600
    IGAVIGPKGA MINQIQDDTG ADITIEDDGT VLIGATDGAS AEAARSAVNA 650
    IANPQVPEVG ERYLGTVVKL TTFGAFVSLT PGKDGLLHVS ELRKLNEGKR 700
    VDDVEDVLGV GQKVQVEITK IDDRGKLSLS PVGAESDAVA ETADAIESSQ 750
    TEA 753
    Length:753
    Mass (Da):80,493
    Last modified:July 28, 2009 - v1
    Checksum:iCEB3A92448CFD330
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001628 Genomic DNA. Translation: ACS30242.1.
    RefSeqiWP_010079121.1. NZ_CABC01000046.1.
    YP_002956796.1. NC_012803.1.

    Genome annotation databases

    EnsemblBacteriaiACS30242; ACS30242; Mlut_07100.
    GeneIDi7984906.
    KEGGimlu:Mlut_07100.
    PATRICi22622057. VBIMicLut29563_0673.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001628 Genomic DNA. Translation: ACS30242.1 .
    RefSeqi WP_010079121.1. NZ_CABC01000046.1.
    YP_002956796.1. NC_012803.1.

    3D structure databases

    ProteinModelPortali C5C9U0.
    SMRi C5C9U0. Positions 5-726.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 465515.Mlut_07100.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACS30242 ; ACS30242 ; Mlut_07100 .
    GeneIDi 7984906.
    KEGGi mlu:Mlut_07100.
    PATRICi 22622057. VBIMicLut29563_0673.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218326.
    KOi K00962.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci MLUT465515:GHH6-709-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR014069. pppGpp_PNP.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    TIGR02696. pppGpp_PNP. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230.

    Entry informationi

    Entry nameiPNP_MICLC
    AccessioniPrimary (citable) accession number: C5C9U0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3