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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) (Micrococcus lysodeikticus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi523MagnesiumUniRule annotation1
Metal bindingi529MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciMLUT465515:G1GEW-704-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Mlut_07100
OrganismiMicrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) (Micrococcus lysodeikticus)
Taxonomic identifieri465515 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaeMicrococcus
Proteomesi
  • UP000000738 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002156641 – 753Polyribonucleotide nucleotidyltransferaseAdd BLAST753

Proteomic databases

PRIDEiC5C9U0

Interactioni

Protein-protein interaction databases

STRINGi465515.MlutN2_010100003623

Structurei

3D structure databases

ProteinModelPortaliC5C9U0
SMRiC5C9U0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini589 – 648KHUniRule annotationAdd BLAST60
Domaini660 – 732S1 motifUniRule annotationAdd BLAST73

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62 Bacteria
COG1185 LUCA
HOGENOMiHOG000218326
KOiK00962
OMAiRYMHNYN
OrthoDBiPOG091H00M0

Family and domain databases

Gene3Di3.30.230.70, 2 hits
HAMAPiMF_01595 PNPase, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR036345 ExoRNase_PH_dom2_sf
IPR014069 GPSI/PNP
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012340 NA-bd_OB-fold
IPR012162 PNPase
IPR027408 PNPase/RNase_PH_dom_sf
IPR015848 PNPase_PH_RNA-bd_bac/org-type
IPR020568 Ribosomal_S5_D2-typ_fold
IPR022967 S1_dom
IPR003029 S1_domain
PANTHERiPTHR11252 PTHR11252, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF03726 PNPase, 1 hit
PF01138 RNase_PH, 2 hits
PF00575 S1, 1 hit
PIRSFiPIRSF005499 PNPase, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF54211 SSF54211, 2 hits
SSF54791 SSF54791, 1 hit
SSF55666 SSF55666, 2 hits
TIGRFAMsiTIGR03591 polynuc_phos, 1 hit
TIGR02696 pppGpp_PNP, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

C5C9U0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGPEITFAE AVIDNGSYGK RTVRFETGRL AQQAAGAAMV YLDEETSMLS
60 70 80 90 100
ATTVGKSPRE GFDFFPLTVD VEERMYASGR IPGSFFRREG RPSTDAILTC
110 120 130 140 150
RLIDRPLRPA FVKGIRNEVQ VVVTVTSIAP DEIYDTVAIN AASLSTQLSG
160 170 180 190 200
LPFSGPIGGV RMALMDDGSG ARQWVAFPKH SQLKGAVFNM AVAGRVVGDD
210 220 230 240 250
VAIMMVEAEA TPDSWTLVKE RGAQAPTEEI VAEGLEAAKP FIRALCEAQA
260 270 280 290 300
DLVKRAGKDP VDVPVFQDYQ DDAYAAVEKL ATDRLTEIFS IADKQERESA
310 320 330 340 350
SYAYLLEVLE ELAGEGKDFA ERKGEIAKAY GSLTKQIVRR RILTDQVRID
360 370 380 390 400
GRGLTDIRKL TAEVEVLPRV HGSAIFERGE TQIMGVTTLN MLKMEQQIDS
410 420 430 440 450
LSPETAKRYM HHYNFPPYST GETGRVGSPK RREIGHGALA ERALVPVLPA
460 470 480 490 500
REEFPYAIRQ VSEALSSNGS TSMGSVCAST LSLLNAGVPL RAHVAGIAMG
510 520 530 540 550
LVSAEVDGQT QYAALTDILG AEDAFGDMDF KVAGTAEFVT AIQLDTKLDG
560 570 580 590 600
IPASVLASAL TQAREARLHI LSVLNAAIDA PDEMAPTAPR IISVRIPVDK
610 620 630 640 650
IGAVIGPKGA MINQIQDDTG ADITIEDDGT VLIGATDGAS AEAARSAVNA
660 670 680 690 700
IANPQVPEVG ERYLGTVVKL TTFGAFVSLT PGKDGLLHVS ELRKLNEGKR
710 720 730 740 750
VDDVEDVLGV GQKVQVEITK IDDRGKLSLS PVGAESDAVA ETADAIESSQ

TEA
Length:753
Mass (Da):80,493
Last modified:July 28, 2009 - v1
Checksum:iCEB3A92448CFD330
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001628 Genomic DNA Translation: ACS30242.1
RefSeqiWP_010079121.1, NZ_CABC01000046.1

Genome annotation databases

EnsemblBacteriaiACS30242; ACS30242; Mlut_07100
GeneIDi7984906
KEGGimlu:Mlut_07100
PATRICifig|465515.4.peg.673

Similar proteinsi

Entry informationi

Entry nameiPNP_MICLC
AccessioniPrimary (citable) accession number: C5C9U0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: May 23, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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