ID   C5C8P4_MICLC            Unreviewed;       593 AA.
AC   C5C8P4;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 70.
DE   SubName: Full=Acyl-CoA synthetase/AMP-acid ligase {ECO:0000313|EMBL:ACS29846.1};
DE   SubName: Full=Benzoate--CoA ligase {ECO:0000313|EMBL:SQG48739.1};
DE            EC=6.2.1.25 {ECO:0000313|EMBL:SQG48739.1};
GN   Name=bclA {ECO:0000313|EMBL:SQG48739.1};
GN   OrderedLocusNames=Mlut_02890 {ECO:0000313|EMBL:ACS29846.1};
GN   ORFNames=NCTC2665_01311 {ECO:0000313|EMBL:SQG48739.1};
OS   Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 /
OS   NCIMB 9278 / NCTC 2665 / VKM Ac-2230) (Micrococcus lysodeikticus).
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC   Micrococcus.
OX   NCBI_TaxID=465515 {ECO:0000313|EMBL:ACS29846.1, ECO:0000313|Proteomes:UP000000738};
RN   [1] {ECO:0000313|EMBL:ACS29846.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NCTC 2665 {ECO:0000313|EMBL:ACS29846.1};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Lowry S., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Lykidis A., Young M., Greenblatt C.;
RT   "Complete sequence of Micrococcus luteus NCTC 2665.";
RL   Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000000738}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 /
RC   NCTC 2665 / VKM Ac-2230 {ECO:0000313|Proteomes:UP000000738};
RX   PubMed=19948807; DOI=10.1128/JB.01254-09;
RA   Young M., Artsatbanov V., Beller H.R., Chandra G., Chater K.F., Dover L.G.,
RA   Goh E.B., Kahan T., Kaprelyants A.S., Kyrpides N., Lapidus A., Lowry S.R.,
RA   Lykidis A., Mahillon J., Markowitz V., Mavromatis K., Mukamolova G.V.,
RA   Oren A., Rokem J.S., Smith M.C., Young D.I., Greenblatt C.L.;
RT   "Genome sequence of the Fleming strain of Micrococcus luteus, a simple
RT   free-living actinobacterium.";
RL   J. Bacteriol. 192:841-860(2010).
RN   [3] {ECO:0000313|EMBL:SQG48739.1, ECO:0000313|Proteomes:UP000248985}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC2665 {ECO:0000313|EMBL:SQG48739.1,
RC   ECO:0000313|Proteomes:UP000248985};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000256|ARBA:ARBA00006432}.
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DR   EMBL; CP001628; ACS29846.1; -; Genomic_DNA.
DR   EMBL; LS483396; SQG48739.1; -; Genomic_DNA.
DR   RefSeq; WP_010079520.1; NZ_WBMF01000069.1.
DR   AlphaFoldDB; C5C8P4; -.
DR   STRING; 465515.Mlut_02890; -.
DR   EnsemblBacteria; ACS29846; ACS29846; Mlut_02890.
DR   KEGG; mlu:Mlut_02890; -.
DR   PATRIC; fig|465515.4.peg.267; -.
DR   eggNOG; COG0365; Bacteria.
DR   HOGENOM; CLU_000022_59_10_11; -.
DR   Proteomes; UP000000738; Chromosome.
DR   Proteomes; UP000248985; Chromosome 1.
DR   GO; GO:0018858; F:benzoate-CoA ligase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR43605:SF10; ACYL-COA SYNTHETASE MEDIUM CHAIN FAMILY MEMBER 3; 1.
DR   PANTHER; PTHR43605; ACYL-COENZYME A SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   3: Inferred from homology;
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:ACS29846.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000738}.
FT   DOMAIN          64..418
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          480..557
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
FT   REGION          570..593
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   593 AA;  65501 MW;  B8E2E4F85EDBD3C4 CRC64;
     MTVQDPTAVA APSPTEVFRA ARDLLVECQT DDERARAEFE WPRFEHFNFG FDWFDRLAQD
     PARADVPALI IAEDDGRSTE RTFAELSAAS NRVANWLSAQ GLRRGDRLIL MLNNQVELWE
     FMLACIKLRV VMVPTTTQMT SGDLEDRVTR AGAAWAVAGA EDLAKFAGVG EDLHLVHVPG
     VFAEGPARRA PEVAGHTVLS YDDADDAATE LTPAEPTPAD ETLLFYFTSG TTSKPKLVEH
     THTSYPVGHL TTLYWIGLEP GDVHLNVASP GWAKHAWSNF FAPWIAEATI FVHNARKFDP
     AALMANMERY GVTSFCAPPT VWRMLIKADL AQLTTPPTKT ISAGEPLNAE VIDQVHKAWG
     TTIRDGFGMT ETTLQVANTP GQKVVIGSMG RPLPGMDVTL IDPLTGQEAD EGEICLRLDP
     RPVGLLKSYY GNQEKTDEVF RDGVFHTGDI ARRDENGVLT YVGRADDVFK SSDYKVSPFE
     LESVLVKHPA VMEGAIVPTP DELRLAVPKA FVTLAPGHEP TVETARAILQ FTLTQLPPYK
     RIRRIEFLEL PKTISGKIRR VELRKAEVER AQTGAAPDGY GTEFREEDLD LQR
//