ID   C5C841_MICLC            Unreviewed;       481 AA.
AC   C5C841;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 68.
DE   SubName: Full=Cell division protein FtsI/penicillin-binding protein 2 {ECO:0000313|EMBL:ACS29643.1};
DE   SubName: Full=Penicillin-binding protein A {ECO:0000313|EMBL:SQG48316.1};
GN   Name=pbpA {ECO:0000313|EMBL:SQG48316.1};
GN   OrderedLocusNames=Mlut_00770 {ECO:0000313|EMBL:ACS29643.1};
GN   ORFNames=NCTC2665_01093 {ECO:0000313|EMBL:SQG48316.1};
OS   Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 /
OS   NCIMB 9278 / NCTC 2665 / VKM Ac-2230) (Micrococcus lysodeikticus).
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC   Micrococcus.
OX   NCBI_TaxID=465515 {ECO:0000313|EMBL:ACS29643.1, ECO:0000313|Proteomes:UP000000738};
RN   [1] {ECO:0000313|EMBL:ACS29643.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NCTC 2665 {ECO:0000313|EMBL:ACS29643.1};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Lowry S., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Lykidis A., Young M., Greenblatt C.;
RT   "Complete sequence of Micrococcus luteus NCTC 2665.";
RL   Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000000738}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 /
RC   NCTC 2665 / VKM Ac-2230 {ECO:0000313|Proteomes:UP000000738};
RX   PubMed=19948807; DOI=10.1128/JB.01254-09;
RA   Young M., Artsatbanov V., Beller H.R., Chandra G., Chater K.F., Dover L.G.,
RA   Goh E.B., Kahan T., Kaprelyants A.S., Kyrpides N., Lapidus A., Lowry S.R.,
RA   Lykidis A., Mahillon J., Markowitz V., Mavromatis K., Mukamolova G.V.,
RA   Oren A., Rokem J.S., Smith M.C., Young D.I., Greenblatt C.L.;
RT   "Genome sequence of the Fleming strain of Micrococcus luteus, a simple
RT   free-living actinobacterium.";
RL   J. Bacteriol. 192:841-860(2010).
RN   [3] {ECO:0000313|EMBL:SQG48316.1, ECO:0000313|Proteomes:UP000248985}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC2665 {ECO:0000313|EMBL:SQG48316.1,
RC   ECO:0000313|Proteomes:UP000248985};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the transpeptidase family.
CC       {ECO:0000256|ARBA:ARBA00007171}.
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DR   EMBL; CP001628; ACS29643.1; -; Genomic_DNA.
DR   EMBL; LS483396; SQG48316.1; -; Genomic_DNA.
DR   RefSeq; WP_010079719.1; NZ_WBMF01000077.1.
DR   AlphaFoldDB; C5C841; -.
DR   STRING; 465515.Mlut_00770; -.
DR   EnsemblBacteria; ACS29643; ACS29643; Mlut_00770.
DR   KEGG; mlu:Mlut_00770; -.
DR   PATRIC; fig|465515.4.peg.56; -.
DR   eggNOG; COG0768; Bacteria.
DR   HOGENOM; CLU_009289_1_0_11; -.
DR   Proteomes; UP000000738; Chromosome.
DR   Proteomes; UP000248985; Chromosome 1.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF24; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE PBPA; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000313|EMBL:ACS29643.1};
KW   Cell division {ECO:0000313|EMBL:ACS29643.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000738}.
FT   DOMAIN          157..459
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
SQ   SEQUENCE   481 AA;  51010 MW;  BEAA0C1C2E28A7C9 CRC64;
     MNEAIRRTWT VMAAMILVLA LAASVIQVLA ADQLKTHALN SRQMFLEFGA PRGPILVDGE
     PIAESVPSDD AYHYQRVYHE PELYAPLTGF YSLTYGTAGL EAAMNEQLSG TPTSQFVDRA
     MEIITGATPE GDQVELTIDP ELQRLAYDAL PDGVRASAVV TDPTTGEILA MVSKPSFDPN
     ALSSHNPAEA QAAMAAIDQI PGASAYRNRA SEQLVSPGST FKLIDAVAML ESGDYTPDGT
     VDIPAAWTLP GTTTELPNYD GSPCNTVGRQ TLTWALAQSC NTPFAMAAVE LGQDRIREAA
     ERFGFNDSFE YPLPVTASVF PSDLDDAALA QSSIGQRDVQ ATALQMAMVA AGIANDGVVM
     EPQLIKAVRR SDLTTVQEFS PRERGRATTP EVAGQVSDMM VSAVEDGILG SVQSDTVRIA
     AKSGTAEVGD TGNVHSWITG FDASENPRAA VTIVVEDEPP GVGHQTVVSG MKAIMEAVVT
     E
//