C5C6P4 (DCD_MICLC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxycytidine triphosphate deaminase
Short name=dCTP deaminase
EC=3.5.4.13

Gene names

Name:	dcd
Ordered Locus Names:	Mlut_18990

Organism

Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) (Micrococcus lysodeikticus) [Complete proteome] [HAMAP]

Taxonomic identifier

465515 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Micrococcus › Micrococcus luteus

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	dCTP + H2O = dUTP + NH3. HAMAP-Rule MF_00146
Pathway	Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 1/2. HAMAP-Rule MF_00146
Sequence similarities	Belongs to the dCTP deaminase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dUMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway dUTP biosynthetic process Inferred from electronic annotation. Source: InterPro pyrimidine ribonucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	dCTP deaminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 193	193	Deoxycytidine triphosphate deaminase HAMAP-Rule MF_00146		PRO_1000203361

Sequences

	Sequence		Length	Mass (Da)
	C5C6P4 [UniParc]. Last modified July 28, 2009. Version 1. Checksum: AF678E4152C02894	FASTA	193	21,571
	10 20 30 40 50 60 MLLSDRDIRA ELDSGRVGLD PLDPTMVQPA SVDVRLDRFF RLFDNHRYAH IDPRQEQDEL 70 80 90 100 110 120 TRLVEVDPDE AFILHPGEFV LGSTYEQVTL PDDLAARLEG KSSLGRLGLL THSTAGFIDP 130 140 150 160 170 180 GFSGHVTLEL SNVATLPITL WPGMKIGQLC FFRLSSSAQS PYGTGANQNR YQGQRGPTAS 190 RAHRDFHLTR IER

References

[1]

"Genome sequence of the Fleming strain of Micrococcus luteus, a simple free-living actinobacterium." Young M., Artsatbanov V., Beller H.R., Chandra G., Chater K.F., Dover L.G., Goh E.B., Kahan T., Kaprelyants A.S., Kyrpides N., Lapidus A., Lowry S.R., Lykidis A., Mahillon J., Markowitz V., Mavromatis K., Mukamolova G.V., Oren A. , Rokem J.S., Smith M.C., Young D.I., Greenblatt C.L. J. Bacteriol. 192:841-860(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001628 Genomic DNA. Translation: ACS31382.1.
RefSeq	YP_002957936.1. NC_012803.1.
3D structure databases
ProteinModelPortal	C5C6P4.
SMR	C5C6P4. Positions 1-186.
ModBase	Search...
Protein-protein interaction databases
STRING	465515.Mlut_18990.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACS31382; ACS31382; Mlut_18990.
GeneID	7984619.
KEGG	mlu:Mlut_18990.
PATRIC	22624442. VBIMicLut29563_1836.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0717.
HOGENOM	HOG000228601.
KO	K01494.
ProtClustDB	PRK00416.
Enzyme and pathway databases
BioCyc	MLUT465515:GHH6-1896-MONOMER.
UniPathway	UPA00610; UER00665.
Family and domain databases
HAMAP	MF_00146. dCTP_deaminase.
InterPro	IPR011962. dCTP_deam. IPR008180. dUTP_pyroPase. [Graphical view]
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR02274. dCTP_deam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DCD_MICLC

Accession

Primary (citable) accession number: C5C6P4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	July 28, 2009
Last modified:	May 1, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program