ID   C5C2L2_BEUC1            Unreviewed;       391 AA.
AC   C5C2L2;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 73.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   OrderedLocusNames=Bcav_1440 {ECO:0000313|EMBL:ACQ79698.1};
OS   Beutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432).
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Beutenbergiaceae;
OC   Beutenbergia.
OX   NCBI_TaxID=471853 {ECO:0000313|EMBL:ACQ79698.1, ECO:0000313|Proteomes:UP000007962};
RN   [1] {ECO:0000313|EMBL:ACQ79698.1, ECO:0000313|Proteomes:UP000007962}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-8 / DSM 12333 / NBRC 16432
RC   {ECO:0000313|Proteomes:UP000007962};
RX   PubMed=21304633; DOI=10.4056/sigs.1162;
RA   Land M., Pukall R., Abt B., Goker M., Rohde M., Glavina Del Rio T.,
RA   Tice H., Copeland A., Cheng J.F., Lucas S., Chen F., Nolan M., Bruce D.,
RA   Goodwin L., Pitluck S., Ivanova N., Mavromatis K., Ovchinnikova G.,
RA   Pati A., Chen A., Palaniappan K., Hauser L., Chang Y.J., Jefferies C.C.,
RA   Saunders E., Brettin T., Detter J.C., Han C., Chain P., Bristow J.,
RA   Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.,
RA   Lapidus A.;
RT   "Complete genome sequence of Beutenbergia cavernae type strain (HKI
RT   0122).";
RL   Stand. Genomic Sci. 1:21-28(2009).
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DR   EMBL; CP001618; ACQ79698.1; -; Genomic_DNA.
DR   RefSeq; WP_015881938.1; NC_012669.1.
DR   AlphaFoldDB; C5C2L2; -.
DR   STRING; 471853.Bcav_1440; -.
DR   CAZy; GH33; Glycoside Hydrolase Family 33.
DR   KEGG; bcv:Bcav_1440; -.
DR   eggNOG; COG4409; Bacteria.
DR   HOGENOM; CLU_024620_1_0_11; -.
DR   OrthoDB; 7294637at2; -.
DR   Proteomes; UP000007962; Chromosome.
DR   GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   4: Predicted;
KW   Glycosidase {ECO:0000313|EMBL:ACQ79698.1};
KW   Hydrolase {ECO:0000313|EMBL:ACQ79698.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007962};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..391
FT                   /note="exo-alpha-sialidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002949308"
FT   DOMAIN          83..366
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
SQ   SEQUENCE   391 AA;  40434 MW;  65260BD817807443 CRC64;
     MRVLPVVALG ASLALLSTAP PATPAPDTTT PEHIVLFEQG RGGYECYRIP AIVRTSDGGL
     LAFAEGRRPA THTTAWCHDA APIDVVVRRS DDDGVTWGPV SVVLSGDPAG GDEEATRGNP
     APVVVTRGEH AGRIVLVTTH NPAGGGVRTP YVQTSDDDGR TWSEATSLAH LPPDGTGWYA
     TGPQHGIQLT SGPHRGRLVV GVNYDAGGVR FGGLLLSDDG GDTWRAGAAA AAVDPADIPQ
     ELGVVETPGG GVLAVARNQN AAGAHQRLAA RSGDGGATFG GQFTGVADLV TTPRVQGSVL
     ALTPPGRPGA SGPLVFSSPV DPTFRRNLTL FRSDDHGRTW ATHAVLTADR AGYSDLVRLG
     DGRLGVLYEG GAYPDGDARD EIRFVAVRVP R
//