ID C5BY21_BEUC1 Unreviewed; 816 AA. AC C5BY21; DT 28-JUL-2009, integrated into UniProtKB/TrEMBL. DT 28-JUL-2009, sequence version 1. DT 27-MAR-2024, entry version 70. DE RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727}; DE EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727}; DE AltName: Full=NHEJ DNA polymerase {ECO:0000256|ARBA:ARBA00029943}; GN OrderedLocusNames=Bcav_0653 {ECO:0000313|EMBL:ACQ78915.1}; OS Beutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432). OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Beutenbergiaceae; OC Beutenbergia. OX NCBI_TaxID=471853 {ECO:0000313|EMBL:ACQ78915.1, ECO:0000313|Proteomes:UP000007962}; RN [1] {ECO:0000313|EMBL:ACQ78915.1, ECO:0000313|Proteomes:UP000007962} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC BAA-8 / DSM 12333 / NBRC 16432 RC {ECO:0000313|Proteomes:UP000007962}; RX PubMed=21304633; DOI=10.4056/sigs.1162; RA Land M., Pukall R., Abt B., Goker M., Rohde M., Glavina Del Rio T., RA Tice H., Copeland A., Cheng J.F., Lucas S., Chen F., Nolan M., Bruce D., RA Goodwin L., Pitluck S., Ivanova N., Mavromatis K., Ovchinnikova G., RA Pati A., Chen A., Palaniappan K., Hauser L., Chang Y.J., Jefferies C.C., RA Saunders E., Brettin T., Detter J.C., Han C., Chain P., Bristow J., RA Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P., RA Lapidus A.; RT "Complete genome sequence of Beutenbergia cavernae type strain (HKI RT 0122)."; RL Stand. Genomic Sci. 1:21-28(2009). CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho- CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003}; CC -!- COFACTOR: CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; CC Evidence={ECO:0000256|ARBA:ARBA00001936}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP001618; ACQ78915.1; -; Genomic_DNA. DR RefSeq; WP_012725695.1; NC_012669.1. DR AlphaFoldDB; C5BY21; -. DR STRING; 471853.Bcav_0653; -. DR KEGG; bcv:Bcav_0653; -. DR eggNOG; COG1793; Bacteria. DR eggNOG; COG3285; Bacteria. DR HOGENOM; CLU_008325_2_1_11; -. DR OrthoDB; 9802472at2; -. DR Proteomes; UP000007962; Chromosome. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC. DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW. DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW. DR CDD; cd07906; Adenylation_DNA_ligase_LigD_LigC; 1. DR CDD; cd04863; MtLigD_Pol_like; 1. DR CDD; cd07971; OBF_DNA_ligase_LigD; 1. DR Gene3D; 3.30.1490.70; -; 1. DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1. DR Gene3D; 3.90.920.10; DNA primase, PRIM domain; 1. DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1. DR InterPro; IPR012309; DNA_ligase_ATP-dep_C. DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent. DR InterPro; IPR014146; LigD_ligase_dom. DR InterPro; IPR014144; LigD_PE_domain. DR InterPro; IPR014145; LigD_pol_dom. DR InterPro; IPR033649; MtLigD_Pol-like. DR InterPro; IPR012340; NA-bd_OB-fold. DR NCBIfam; TIGR02777; LigD_PE_dom; 1. DR NCBIfam; TIGR02778; ligD_pol; 1. DR NCBIfam; TIGR02779; NHEJ_ligase_lig; 1. DR PANTHER; PTHR42705; BIFUNCTIONAL NON-HOMOLOGOUS END JOINING PROTEIN LIGD; 1. DR PANTHER; PTHR42705:SF2; MULTIFUNCTIONAL NON-HOMOLOGOUS END JOINING DNA REPAIR PROTEIN LIGD; 1. DR Pfam; PF04679; DNA_ligase_A_C; 1. DR Pfam; PF01068; DNA_ligase_A_M; 1. DR Pfam; PF13298; LigD_N; 1. DR Pfam; PF21686; LigD_Prim-Pol; 1. DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1. DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1. DR PROSITE; PS50160; DNA_LIGASE_A3; 1. PE 4: Predicted; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840}; KW DNA damage {ECO:0000256|ARBA:ARBA00022763}; KW DNA recombination {ECO:0000256|ARBA:ARBA00023172}; KW DNA repair {ECO:0000256|ARBA:ARBA00023204}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}; KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932}; KW Exonuclease {ECO:0000256|ARBA:ARBA00022839}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Ligase {ECO:0000256|ARBA:ARBA00022598}; KW Manganese {ECO:0000256|ARBA:ARBA00023211}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268}; KW Nuclease {ECO:0000256|ARBA:ARBA00022722}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695}; KW Reference proteome {ECO:0000313|Proteomes:UP000007962}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}. FT DOMAIN 600..727 FT /note="ATP-dependent DNA ligase family profile" FT /evidence="ECO:0000259|PROSITE:PS50160" SQ SEQUENCE 816 AA; 88722 MW; E544CDD9BA9970E9 CRC64; MAAGDGGARV RVDGRVLSLT NLDKVLFPAT GTTKAELIDY YRRIAPVMIP HLAGRAVTRK RWPNGVETEP FFTKNLDSGT PDWVPRRGIV HHERTSTYPL VEDTATLVWL AQMASIELHV PQWRFPPGDS PFVLDGSATR PDRFVLDLDP GPGVGLAQCA EVALAAKGYL DDVGLAAIPV TSGSKGLHLY ATIHGVSSEQ ASAFAKELAG HLAEDLPQLV VTQMKRSLRD GKVFVDYSQN NAAKTTVSPY SVRGRDQPWV AAPRTWGELG EPGLAHLELG EVLERAADGD LLAPLLPPDP LSTYRAKRDS ARTPEPVPFA APVAAPAGDP RFVIQEHHAR RLHWDLRLEH DGVLASWAVP RGVPTTTGHN RLAVHTEDHP MEYLTFHGSI PKGEYGGGEM TVWDTGTYTP EKFRDDEVIF VLHGQRVQGR FALIRTDPGR GGGKEQWLLH LMKDQSGVAT SPEKRAHAVV DAPDAAADDG AHISLSDAVE PRRIAPDLRP MLATAGQVGD GDYPAREWAF EPKWDGYRAL VRFSARGVAL QSRSGRDFTQ EFAELAVVPE ELAAHAGVLD AEIVALDAAG RPSFHALQER GTGARPAMRL LVFDVLHLDG TSLVNKRYSD RRQVLLALPL PAADPDHLGR EERDVGGWRR SVTIGTSVRA ALRASAEARL EGVIAKRLDA RYLPGRRGHA WVKLKHSLDA EVVIGGWRPG QGRRAGGIGS LLLGVPDDDG GLRYVGKVGT GFTDAALDAL LATLEPRERT TSPFTTEVPR VEAKVAHWVR PDVVGEVTFD SWTDDGVLRA ARWRGLRPDK APADLA //