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C5BWR2

- PNP_BEUC1

UniProt

C5BWR2 - PNP_BEUC1

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Beutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi515 – 5151MagnesiumUniRule annotation
Metal bindingi521 – 5211MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciBCAV471853:GI1Z-2515-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Bcav_2478
OrganismiBeutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432)
Taxonomic identifieri471853 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeBeutenbergiaceaeBeutenbergia
ProteomesiUP000007962: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 744744Polyribonucleotide nucleotidyltransferasePRO_1000215655Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi471853.Bcav_2478.

Structurei

3D structure databases

ProteinModelPortaliC5BWR2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini581 – 64060KHUniRule annotationAdd
BLAST
Domaini652 – 72473S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiTIAGKQD.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5BWR2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGPEIQFAE ATIDNGRFGT RTVRFETGRL AKQAAGAVLA TLDEDTVVLS
60 70 80 90 100
TTAAGKHPKE QFDFFPLTVD VEERQYAAGK IPGSFFRREG RPSTEAILAC
110 120 130 140 150
RLIDRPLRPL FVKGLRNEVQ VVETILAIHP DDSYDVLAIN AASASTQISG
160 170 180 190 200
LPFSGPVGGV RVALIDGTWV GFPRYSEKER AVFDMVVAGR VVGDDVAITM
210 220 230 240 250
VEAEATDNAW ELIKGEGAGA PTEEVVAEGL EAAKPFIRAL CEAQAALASR
260 270 280 290 300
AAKEVQVFPV FPEYEPDAYD AVEQQVADHL DAALRIADKQ ERESRLDEIK
310 320 330 340 350
DAAVGALQAG FDGREKELSA AYRALTKKFI RRHILTDSFR IDGRGLKDIR
360 370 380 390 400
PLTAEVEVLP RVHGSALFER GETQILGVTT LNMLKMEQQL DTLSPVSRKR
410 420 430 440 450
YMHNYNFPPY STGETGRVGS PKRREIGHGA LAERALVPVL PARDEFPYAI
460 470 480 490 500
RQVSEALSSN GSTSMGSVCA STLSMLNAGV PLRAPVAGIA MGLVSDEVDG
510 520 530 540 550
ETRYATLTDI LGAEDAFGDM DFKVAGTREF VTAIQLDTKL DGIPASVLAG
560 570 580 590 600
ALSQAREARL HILDVMAEAI DTPDEMAATA PRVITVQVPV DKIGEVIGPK
610 620 630 640 650
GKMINQIQDD TGADISIEDD GTVFIGATDG PSAEAARQAI NAIANPHMPE
660 670 680 690 700
VGERFVGTVV KTTSFGAFVS LTPGKDGLLH ISQIRRLVGG KRVENVEDVL
710 720 730 740
GVGQKVQVEI AEIDPRGKLS LHAVVEETPA DDAPAEASTA TADA
Length:744
Mass (Da):79,726
Last modified:July 28, 2009 - v1
Checksum:iFCAC4823D6EB0C9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001618 Genomic DNA. Translation: ACQ80728.1.
RefSeqiYP_002882490.1. NC_012669.1.

Genome annotation databases

EnsemblBacteriaiACQ80728; ACQ80728; Bcav_2478.
GeneIDi7862012.
KEGGibcv:Bcav_2478.
PATRICi21095628. VBIBeuCav91323_2521.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001618 Genomic DNA. Translation: ACQ80728.1 .
RefSeqi YP_002882490.1. NC_012669.1.

3D structure databases

ProteinModelPortali C5BWR2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 471853.Bcav_2478.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACQ80728 ; ACQ80728 ; Bcav_2478 .
GeneIDi 7862012.
KEGGi bcv:Bcav_2478.
PATRICi 21095628. VBIBeuCav91323_2521.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi TIAGKQD.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci BCAV471853:GI1Z-2515-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-8 / DSM 12333 / NBRC 16432.

Entry informationi

Entry nameiPNP_BEUC1
AccessioniPrimary (citable) accession number: C5BWR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: November 26, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3