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Protein

Probable DNA ligase

Gene

lig

Organism
Beutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei217ATPUniRule annotation1
Active sitei219N6-AMP-lysine intermediateUniRule annotation1
Binding sitei224ATPUniRule annotation1
Binding sitei239ATPUniRule annotation1
Binding sitei268ATPUniRule annotation1
Binding sitei306ATPUniRule annotation1
Binding sitei377ATPUniRule annotation1
Binding sitei383ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBCAV471853:G1GET-271-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Bcav_0272
OrganismiBeutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432)
Taxonomic identifieri471853 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesBeutenbergiaceaeBeutenbergia
Proteomesi
  • UP000007962 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002059541 – 512Probable DNA ligaseAdd BLAST512

Proteomic databases

PRIDEiC5BW79

Interactioni

Protein-protein interaction databases

STRINGi471853.Bcav_0272

Structurei

3D structure databases

SMRiC5BW79
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RYT Bacteria
COG1793 LUCA
HOGENOMiHOG000036008
KOiK10747
OMAiWLFEESY
OrthoDBiPOG091H0BGA

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

C5BW79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLAEVAATS DAVAATRSRL AKRAAIADLL RRAPADDVEI VVAYVAGELR
60 70 80 90 100
QRRTGLGWRS LRDLPGPAED PSLEVADVDA TFAAMADLAG PGSATARAAA
110 120 130 140 150
AAELFAAATE REQALLRGLV SGELRQGALD ALVLDAVADA AGVPAPEVRR
160 170 180 190 200
AAMFAGATGP VARAALAAAG PAEAVAALSG FMLTVGRAVR PMLAQSAPDV
210 220 230 240 250
AAAFAKLPGG DVAVSVDVKL DGIRIQVHKA GDEVRVFTRS LDDITGRVPE
260 270 280 290 300
IVEAVRALPA GALVLDGEAL AVDAGGRPRP FQETASRSAT RDADVAAAMT
310 320 330 340 350
LTPFFFDCLH ADGRDLVDAP LRERLEVLDA VAGPHVVTRL TTSDPAAAEE
360 370 380 390 400
FFAAAVRDGQ EGVVVKATDT PYEAGRRGAG WIKVKPRHTL DLVVLAVEWG
410 420 430 440 450
SGRRRGWLSN IHLGARDPAG GFVMLGKTFK GMTDEMLAWQ TERFLELETS
460 470 480 490 500
RDEWAVHLRP EQVVEIAFDG LQRSTRYPGG LALRFARVLR YRDDKTAAEA
510
DTIDTVRTLA GL
Length:512
Mass (Da):53,976
Last modified:July 28, 2009 - v1
Checksum:iEC4172653DFF126F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001618 Genomic DNA Translation: ACQ78537.1
RefSeqiWP_012725317.1, NC_012669.1

Genome annotation databases

EnsemblBacteriaiACQ78537; ACQ78537; Bcav_0272
KEGGibcv:Bcav_0272

Similar proteinsi

Entry informationi

Entry nameiDNLI_BEUC1
AccessioniPrimary (citable) accession number: C5BW79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: May 23, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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