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C5BW79

- DNLI_BEUC1

UniProt

C5BW79 - DNLI_BEUC1

Protein

Probable DNA ligase

Gene

lig

Organism
Beutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei217 – 2171ATPUniRule annotation
    Active sitei219 – 2191N6-AMP-lysine intermediateUniRule annotation
    Binding sitei224 – 2241ATPUniRule annotation
    Binding sitei239 – 2391ATPUniRule annotation
    Binding sitei268 – 2681ATPUniRule annotation
    Binding sitei306 – 3061ATPUniRule annotation
    Binding sitei377 – 3771ATPUniRule annotation
    Binding sitei383 – 3831ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBCAV471853:GI1Z-275-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:Bcav_0272
    OrganismiBeutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432)
    Taxonomic identifieri471853 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeBeutenbergiaceaeBeutenbergia
    ProteomesiUP000007962: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 512512Probable DNA ligasePRO_1000205954Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi471853.Bcav_0272.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1793.
    HOGENOMiHOG000036008.
    KOiK01971.
    OMAiRKVKPVH.
    OrthoDBiEOG6Q8HXT.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 2 hits.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 2 hits.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C5BW79-1 [UniParc]FASTAAdd to Basket

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    MLLAEVAATS DAVAATRSRL AKRAAIADLL RRAPADDVEI VVAYVAGELR    50
    QRRTGLGWRS LRDLPGPAED PSLEVADVDA TFAAMADLAG PGSATARAAA 100
    AAELFAAATE REQALLRGLV SGELRQGALD ALVLDAVADA AGVPAPEVRR 150
    AAMFAGATGP VARAALAAAG PAEAVAALSG FMLTVGRAVR PMLAQSAPDV 200
    AAAFAKLPGG DVAVSVDVKL DGIRIQVHKA GDEVRVFTRS LDDITGRVPE 250
    IVEAVRALPA GALVLDGEAL AVDAGGRPRP FQETASRSAT RDADVAAAMT 300
    LTPFFFDCLH ADGRDLVDAP LRERLEVLDA VAGPHVVTRL TTSDPAAAEE 350
    FFAAAVRDGQ EGVVVKATDT PYEAGRRGAG WIKVKPRHTL DLVVLAVEWG 400
    SGRRRGWLSN IHLGARDPAG GFVMLGKTFK GMTDEMLAWQ TERFLELETS 450
    RDEWAVHLRP EQVVEIAFDG LQRSTRYPGG LALRFARVLR YRDDKTAAEA 500
    DTIDTVRTLA GL 512
    Length:512
    Mass (Da):53,976
    Last modified:July 28, 2009 - v1
    Checksum:iEC4172653DFF126F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001618 Genomic DNA. Translation: ACQ78537.1.
    RefSeqiWP_012725317.1. NC_012669.1.
    YP_002880299.1. NC_012669.1.

    Genome annotation databases

    EnsemblBacteriaiACQ78537; ACQ78537; Bcav_0272.
    GeneIDi7860066.
    KEGGibcv:Bcav_0272.
    PATRICi21091073. VBIBeuCav91323_0275.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001618 Genomic DNA. Translation: ACQ78537.1 .
    RefSeqi WP_012725317.1. NC_012669.1.
    YP_002880299.1. NC_012669.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 471853.Bcav_0272.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACQ78537 ; ACQ78537 ; Bcav_0272 .
    GeneIDi 7860066.
    KEGGi bcv:Bcav_0272.
    PATRICi 21091073. VBIBeuCav91323_0275.

    Phylogenomic databases

    eggNOGi COG1793.
    HOGENOMi HOG000036008.
    KOi K01971.
    OMAi RKVKPVH.
    OrthoDBi EOG6Q8HXT.

    Enzyme and pathway databases

    BioCyci BCAV471853:GI1Z-275-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 2 hits.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 2 hits.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-8 / DSM 12333 / NBRC 16432.

    Entry informationi

    Entry nameiDNLI_BEUC1
    AccessioniPrimary (citable) accession number: C5BW79
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3