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C5BW79 (DNLI_BEUC1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable DNA ligase

EC=6.5.1.1
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene names
Name:lig
Ordered Locus Names:Bcav_0272
OrganismBeutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432) [Complete proteome] [HAMAP]
Taxonomic identifier471853 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeBeutenbergiaceaeBeutenbergia

Protein attributes

Sequence length512 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 512512Probable DNA ligase HAMAP-Rule MF_00407
PRO_1000205954

Sites

Active site2191N6-AMP-lysine intermediate By similarity
Binding site2171ATP By similarity
Binding site2241ATP By similarity
Binding site2391ATP By similarity
Binding site2681ATP By similarity
Binding site3061ATP By similarity
Binding site3771ATP By similarity
Binding site3831ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
C5BW79 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: EC4172653DFF126F

FASTA51253,976
        10         20         30         40         50         60 
MLLAEVAATS DAVAATRSRL AKRAAIADLL RRAPADDVEI VVAYVAGELR QRRTGLGWRS 

        70         80         90        100        110        120 
LRDLPGPAED PSLEVADVDA TFAAMADLAG PGSATARAAA AAELFAAATE REQALLRGLV 

       130        140        150        160        170        180 
SGELRQGALD ALVLDAVADA AGVPAPEVRR AAMFAGATGP VARAALAAAG PAEAVAALSG 

       190        200        210        220        230        240 
FMLTVGRAVR PMLAQSAPDV AAAFAKLPGG DVAVSVDVKL DGIRIQVHKA GDEVRVFTRS 

       250        260        270        280        290        300 
LDDITGRVPE IVEAVRALPA GALVLDGEAL AVDAGGRPRP FQETASRSAT RDADVAAAMT 

       310        320        330        340        350        360 
LTPFFFDCLH ADGRDLVDAP LRERLEVLDA VAGPHVVTRL TTSDPAAAEE FFAAAVRDGQ 

       370        380        390        400        410        420 
EGVVVKATDT PYEAGRRGAG WIKVKPRHTL DLVVLAVEWG SGRRRGWLSN IHLGARDPAG 

       430        440        450        460        470        480 
GFVMLGKTFK GMTDEMLAWQ TERFLELETS RDEWAVHLRP EQVVEIAFDG LQRSTRYPGG 

       490        500        510 
LALRFARVLR YRDDKTAAEA DTIDTVRTLA GL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001618 Genomic DNA. Translation: ACQ78537.1.
RefSeqYP_002880299.1. NC_012669.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING471853.Bcav_0272.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACQ78537; ACQ78537; Bcav_0272.
GeneID7860066.
KEGGbcv:Bcav_0272.
PATRIC21091073. VBIBeuCav91323_0275.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1793.
HOGENOMHOG000036008.
KOK01971.
OMARKVKPVH.
OrthoDBEOG6Q8HXT.

Enzyme and pathway databases

BioCycBCAV471853:GI1Z-275-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI_BEUC1
AccessionPrimary (citable) accession number: C5BW79
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: May 14, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families