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Protein

Probable DNA ligase

Gene

lig

Organism
Beutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei217 – 2171ATPUniRule annotation
Active sitei219 – 2191N6-AMP-lysine intermediateUniRule annotation
Binding sitei224 – 2241ATPUniRule annotation
Binding sitei239 – 2391ATPUniRule annotation
Binding sitei268 – 2681ATPUniRule annotation
Binding sitei306 – 3061ATPUniRule annotation
Binding sitei377 – 3771ATPUniRule annotation
Binding sitei383 – 3831ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBCAV471853:GI1Z-275-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Bcav_0272
OrganismiBeutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432)
Taxonomic identifieri471853 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesBeutenbergiaceaeBeutenbergia
ProteomesiUP000007962 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Probable DNA ligasePRO_1000205954Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi471853.Bcav_0272.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK10747.
OMAiGRPRPFQ.
OrthoDBiEOG6Q8HXT.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5BW79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLAEVAATS DAVAATRSRL AKRAAIADLL RRAPADDVEI VVAYVAGELR
60 70 80 90 100
QRRTGLGWRS LRDLPGPAED PSLEVADVDA TFAAMADLAG PGSATARAAA
110 120 130 140 150
AAELFAAATE REQALLRGLV SGELRQGALD ALVLDAVADA AGVPAPEVRR
160 170 180 190 200
AAMFAGATGP VARAALAAAG PAEAVAALSG FMLTVGRAVR PMLAQSAPDV
210 220 230 240 250
AAAFAKLPGG DVAVSVDVKL DGIRIQVHKA GDEVRVFTRS LDDITGRVPE
260 270 280 290 300
IVEAVRALPA GALVLDGEAL AVDAGGRPRP FQETASRSAT RDADVAAAMT
310 320 330 340 350
LTPFFFDCLH ADGRDLVDAP LRERLEVLDA VAGPHVVTRL TTSDPAAAEE
360 370 380 390 400
FFAAAVRDGQ EGVVVKATDT PYEAGRRGAG WIKVKPRHTL DLVVLAVEWG
410 420 430 440 450
SGRRRGWLSN IHLGARDPAG GFVMLGKTFK GMTDEMLAWQ TERFLELETS
460 470 480 490 500
RDEWAVHLRP EQVVEIAFDG LQRSTRYPGG LALRFARVLR YRDDKTAAEA
510
DTIDTVRTLA GL
Length:512
Mass (Da):53,976
Last modified:July 28, 2009 - v1
Checksum:iEC4172653DFF126F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001618 Genomic DNA. Translation: ACQ78537.1.
RefSeqiWP_012725317.1. NC_012669.1.
YP_002880299.1. NC_012669.1.

Genome annotation databases

EnsemblBacteriaiACQ78537; ACQ78537; Bcav_0272.
KEGGibcv:Bcav_0272.
PATRICi21091073. VBIBeuCav91323_0275.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001618 Genomic DNA. Translation: ACQ78537.1.
RefSeqiWP_012725317.1. NC_012669.1.
YP_002880299.1. NC_012669.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi471853.Bcav_0272.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACQ78537; ACQ78537; Bcav_0272.
KEGGibcv:Bcav_0272.
PATRICi21091073. VBIBeuCav91323_0275.

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK10747.
OMAiGRPRPFQ.
OrthoDBiEOG6Q8HXT.

Enzyme and pathway databases

BioCyciBCAV471853:GI1Z-275-MONOMER.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-8 / DSM 12333 / NBRC 16432.

Entry informationi

Entry nameiDNLI_BEUC1
AccessioniPrimary (citable) accession number: C5BW79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: June 24, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.