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C5BVA2 (PSB_BEUC1) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteasome subunit beta

EC=3.4.25.1
Alternative name(s):
20S proteasome beta subunit
Proteasome core protein PrcB
Gene names
Name:prcB
Ordered Locus Names:Bcav_2238
OrganismBeutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432) [Complete proteome] [HAMAP]
Taxonomic identifier471853 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeBeutenbergiaceaeBeutenbergia

Protein attributes

Sequence length272 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation By similarity. HAMAP-Rule MF_02113

Catalytic activity

Cleavage of peptide bonds with very broad specificity. HAMAP-Rule MF_02113

Enzyme regulation

The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity By similarity. HAMAP-Rule MF_02113

Pathway

Protein degradation; proteasomal Pup-dependent pathway. HAMAP-Rule MF_02113

Subunit structure

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_02113.

Sequence similarities

Belongs to the peptidase T1B family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide1 – 4747Removed in mature form; by autocatalysis By similarity
PRO_0000397500
Chain48 – 272225Proteasome subunit beta HAMAP-Rule MF_02113
PRO_0000397501

Sites

Active site481Nucleophile By similarity

Sequences

Sequence LengthMass (Da)Tools
C5BVA2 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: C070271DCDB96629

FASTA27228,596
        10         20         30         40         50         60 
MSTGGDRLPE AFLRPGSSSF VEFLREVAPQ SHPEHARPAG AGDVVHATTI VALSFAGGIV 

        70         80         90        100        110        120 
MAGDRRATMG SFIAHREIEK VFPGDEYSAI GIAGTAGIGV ELVRLFQLEL EHFEKIEGAM 

       130        140        150        160        170        180 
LSLEGKANRL TTLLRGNLGL ALQGLAAVPL FGGYDLDRAA GRIFSYDVTG GRYEERNHHS 

       190        200        210        220        230        240 
IGSGGMFARG SLKKLWRPGL GDRDAIAVAL AALVDAADDD SATGGPDALR GIFPVVATVT 

       250        260        270 
AEGYRRIAEG ELAGLVAEID AARAQAREGD TR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001618 Genomic DNA. Translation: ACQ80489.1.
RefSeqYP_002882251.1. NC_012669.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING471853.Bcav_2238.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACQ80489; ACQ80489; Bcav_2238.
GeneID7861434.
KEGGbcv:Bcav_2238.
PATRIC21095124. VBIBeuCav91323_2272.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0638.
HOGENOMHOG000245308.
KOK03433.
OMAFQVELEH.
OrthoDBEOG6XM79W.

Enzyme and pathway databases

BioCycBCAV471853:GI1Z-2270-MONOMER.
UniPathwayUPA00997.

Family and domain databases

Gene3D3.60.20.10. 1 hit.
HAMAPMF_02113_B. Proteasome_B_B.
InterProIPR029055. Ntn_hydrolases_N.
IPR022483. Pept_T1A_Psome_suB_actinobac.
IPR000243. Pept_T1A_subB.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamPF00227. Proteasome. 1 hit.
[Graphical view]
PRINTSPR00141. PROTEASOME.
SUPFAMSSF56235. SSF56235. 1 hit.
TIGRFAMsTIGR03690. 20S_bact_beta. 1 hit.
PROSITEPS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePSB_BEUC1
AccessionPrimary (citable) accession number: C5BVA2
Entry history
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: July 28, 2009
Last modified: June 11, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

PATHWAY comments

Index of metabolic and biosynthesis pathways