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C5BUP9

- C5BUP9_BEUC1

UniProt

C5BUP9 - C5BUP9_BEUC1

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Protein

DNA gyrase subunit A

Gene

gyrA

Organism
Beutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.UniRule annotation

Catalytic activityi

ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei146 – 1461O-(5'-phospho-DNA)-tyrosine intermediateUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: UniProtKB-HAMAP
  3. DNA topoisomerase type II (ATP-hydrolyzing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA-dependent DNA replication Source: UniProtKB-HAMAP
  2. DNA topological change Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, TopoisomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, DNA-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciBCAV471853:GI1Z-7-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA gyrase subunit AUniRule annotation (EC:5.99.1.3UniRule annotation)
Gene namesi
Name:gyrAUniRule annotation
Ordered Locus Names:Bcav_0007Imported
OrganismiBeutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432)Imported
Taxonomic identifieri471853 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeBeutenbergiaceaeBeutenbergia
ProteomesiUP000007962: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. chromosome Source: InterPro
  2. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis.UniRule annotation

Protein-protein interaction databases

STRINGi471853.Bcav_0007.

Family & Domainsi

Sequence similaritiesi

Belongs to the topoisomerase GyrA/ParC subunit family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0188.
HOGENOMiHOG000076278.
KOiK02469.
OMAiPRYTECK.
OrthoDBiEOG661H5V.

Family and domain databases

Gene3Di3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPiMF_01897. GyrA.
InterProiIPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PfamiPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTiSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMiSSF56719. SSF56719. 1 hit.
TIGRFAMsiTIGR01063. gyrA. 1 hit.

Sequencei

Sequence statusi: Complete.

C5BUP9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQPPETPDE RDAETTDAVV SAAGASALRD RVEQVDLQLE MQRSYLDYAM
60 70 80 90 100
SVIVGRALPE VRDGLKPVHR RVLYAMFDGG YRPDSAFSKC ARVVGDVMGN
110 120 130 140 150
YHPHGDTAIY DALVRLVQPW SMRYPLVAGQ GNFGSPGDDS AAAPRYTECK
160 170 180 190 200
MAPLAMEMVR DIDKDTVDFG DNYDGRTQEP LILPARFPNL LVNGSAGIAV
210 220 230 240 250
GMATNIPPHN LREVAEGVEW FLEHPDATNE ELLGALLLRI KGPDFPTGAQ
260 270 280 290 300
ILGHRGIEDA YRTGRGSITM RAVVEVEEIQ GRQCLVVTEL PYQVNPDRLA
310 320 330 340 350
AKIGEMVREG RISGIADLRD ETSGRAGQRL VIVLKRDAVA KVVLNNLYKH
360 370 380 390 400
TQLQDTFGAN MLALVDGVPR TLSLDAFVRH WTMHQIDVIV RRTRYLLAED
410 420 430 440 450
ERRIHILRGL LKALNALDEV IALIRRSPSS DEARTGLMEL LEIDEVQATA
460 470 480 490 500
ILDMQLRRLA ALEQQRIMDE HAAIEARILD YQDILASEER QRSIVRSELG
510 520 530 540 550
AIVERYGDER RTTILPFDGE MSVEDLIPEE DVVVTITRGG YAKRTRTDNY
560 570 580 590 600
RAQRRGGKGV RGAQLREDDV VDHFFVTTTH HWLLFFTNLG RVYRAKGYEL
610 620 630 640 650
PEGGRDAKGQ HVANLLAFQP GEKIAQVLAL RDYDQADYLV LATKRGLVKK
660 670 680 690 700
TRLAEYDSSR TGGVIAINLR TDDGGAVDEV VSARIVGAED DLLLVSRKGQ
710 720 730 740 750
SIRFTATDEA LRPMARATSG VTGMKFRADD ELLAMDVVET DADLFVVTEG
760 770 780 790 800
GFAKRTALGE YRVQGRGGLG IKVANLVEAR GDLVGALVVD SDDEVLVIME
810 820 830 840 850
RGKIVRSAVD EVTRTGRNTQ GVTFAKPDAG DRIIAIALGE ERAVADAGEE
860 870 880
PVEESAEGAP TTDPAEGDGV PSSPEAAPEA EEGQA
Length:885
Mass (Da):97,172
Last modified:July 28, 2009 - v1
Checksum:i6CF4CDD25D407D2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001618 Genomic DNA. Translation: ACQ78273.1.
RefSeqiYP_002880035.1. NC_012669.1.

Genome annotation databases

EnsemblBacteriaiACQ78273; ACQ78273; Bcav_0007.
GeneIDi7858207.
KEGGibcv:Bcav_0007.
PATRICi21090534. VBIBeuCav91323_0009.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001618 Genomic DNA. Translation: ACQ78273.1 .
RefSeqi YP_002880035.1. NC_012669.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 471853.Bcav_0007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACQ78273 ; ACQ78273 ; Bcav_0007 .
GeneIDi 7858207.
KEGGi bcv:Bcav_0007.
PATRICi 21090534. VBIBeuCav91323_0009.

Phylogenomic databases

eggNOGi COG0188.
HOGENOMi HOG000076278.
KOi K02469.
OMAi PRYTECK.
OrthoDBi EOG661H5V.

Enzyme and pathway databases

BioCyci BCAV471853:GI1Z-7-MONOMER.

Family and domain databases

Gene3Di 3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPi MF_01897. GyrA.
InterProi IPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
[Graphical view ]
Pfami PF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view ]
SMARTi SM00434. TOP4c. 1 hit.
[Graphical view ]
SUPFAMi SSF56719. SSF56719. 1 hit.
TIGRFAMsi TIGR01063. gyrA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-8 / DSM 12333 / NBRC 16432Imported.

Entry informationi

Entry nameiC5BUP9_BEUC1
AccessioniPrimary (citable) accession number: C5BUP9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: October 29, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3