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C5BUP9 (C5BUP9_BEUC1) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length885 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP-Rule MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP-Rule MF_01897 SAAS SAAS006691

Subunit structure

Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis By similarity. HAMAP-Rule MF_01897

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP-Rule MF_01897

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1461O-(5'-phospho-DNA)-tyrosine intermediate By similarity HAMAP-Rule MF_01897

Sequences

Sequence LengthMass (Da)Tools
C5BUP9 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 6CF4CDD25D407D2E

FASTA88597,172
        10         20         30         40         50         60 
MTQPPETPDE RDAETTDAVV SAAGASALRD RVEQVDLQLE MQRSYLDYAM SVIVGRALPE 

        70         80         90        100        110        120 
VRDGLKPVHR RVLYAMFDGG YRPDSAFSKC ARVVGDVMGN YHPHGDTAIY DALVRLVQPW 

       130        140        150        160        170        180 
SMRYPLVAGQ GNFGSPGDDS AAAPRYTECK MAPLAMEMVR DIDKDTVDFG DNYDGRTQEP 

       190        200        210        220        230        240 
LILPARFPNL LVNGSAGIAV GMATNIPPHN LREVAEGVEW FLEHPDATNE ELLGALLLRI 

       250        260        270        280        290        300 
KGPDFPTGAQ ILGHRGIEDA YRTGRGSITM RAVVEVEEIQ GRQCLVVTEL PYQVNPDRLA 

       310        320        330        340        350        360 
AKIGEMVREG RISGIADLRD ETSGRAGQRL VIVLKRDAVA KVVLNNLYKH TQLQDTFGAN 

       370        380        390        400        410        420 
MLALVDGVPR TLSLDAFVRH WTMHQIDVIV RRTRYLLAED ERRIHILRGL LKALNALDEV 

       430        440        450        460        470        480 
IALIRRSPSS DEARTGLMEL LEIDEVQATA ILDMQLRRLA ALEQQRIMDE HAAIEARILD 

       490        500        510        520        530        540 
YQDILASEER QRSIVRSELG AIVERYGDER RTTILPFDGE MSVEDLIPEE DVVVTITRGG 

       550        560        570        580        590        600 
YAKRTRTDNY RAQRRGGKGV RGAQLREDDV VDHFFVTTTH HWLLFFTNLG RVYRAKGYEL 

       610        620        630        640        650        660 
PEGGRDAKGQ HVANLLAFQP GEKIAQVLAL RDYDQADYLV LATKRGLVKK TRLAEYDSSR 

       670        680        690        700        710        720 
TGGVIAINLR TDDGGAVDEV VSARIVGAED DLLLVSRKGQ SIRFTATDEA LRPMARATSG 

       730        740        750        760        770        780 
VTGMKFRADD ELLAMDVVET DADLFVVTEG GFAKRTALGE YRVQGRGGLG IKVANLVEAR 

       790        800        810        820        830        840 
GDLVGALVVD SDDEVLVIME RGKIVRSAVD EVTRTGRNTQ GVTFAKPDAG DRIIAIALGE 

       850        860        870        880 
ERAVADAGEE PVEESAEGAP TTDPAEGDGV PSSPEAAPEA EEGQA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001618 Genomic DNA. Translation: ACQ78273.1.
RefSeqYP_002880035.1. NC_012669.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING471853.Bcav_0007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACQ78273; ACQ78273; Bcav_0007.
GeneID7858207.
KEGGbcv:Bcav_0007.
PATRIC21090534. VBIBeuCav91323_0009.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0188.
HOGENOMHOG000076278.
KOK02469.
OMAETVDWVP.
OrthoDBEOG661H5V.
ProtClustDBPRK05560.

Enzyme and pathway databases

BioCycBCAV471853:GI1Z-7-MONOMER.

Family and domain databases

Gene3D3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPMF_01897. GyrA.
InterProIPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. SSF56719. 1 hit.
TIGRFAMsTIGR01063. gyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC5BUP9_BEUC1
AccessionPrimary (citable) accession number: C5BUP9
Entry history
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: April 16, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)