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C5BUP9

- C5BUP9_BEUC1

UniProt

C5BUP9 - C5BUP9_BEUC1

Protein

DNA gyrase subunit A

Gene

gyrA

Organism
Beutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.UniRule annotation

    Catalytic activityi

    ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei146 – 1461O-(5'-phospho-DNA)-tyrosine intermediateUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: UniProtKB-HAMAP
    3. DNA topoisomerase type II (ATP-hydrolyzing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA-dependent DNA replication Source: UniProtKB-HAMAP
    2. DNA topological change Source: InterPro

    Keywords - Molecular functioni

    Isomerase, TopoisomeraseUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, DNA-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBCAV471853:GI1Z-7-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA gyrase subunit AUniRule annotation (EC:5.99.1.3UniRule annotation)
    Gene namesi
    Name:gyrAUniRule annotation
    Ordered Locus Names:Bcav_0007Imported
    OrganismiBeutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432)Imported
    Taxonomic identifieri471853 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeBeutenbergiaceaeBeutenbergia
    ProteomesiUP000007962: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. chromosome Source: InterPro
    2. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis.UniRule annotation

    Protein-protein interaction databases

    STRINGi471853.Bcav_0007.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the topoisomerase GyrA/ParC subunit family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0188.
    HOGENOMiHOG000076278.
    KOiK02469.
    OMAiPRYTECK.
    OrthoDBiEOG661H5V.

    Family and domain databases

    Gene3Di3.30.1360.40. 1 hit.
    3.90.199.10. 2 hits.
    HAMAPiMF_01897. GyrA.
    InterProiIPR024946. Arg_repress_C-like.
    IPR005743. GyrA.
    IPR006691. GyrA/parC_pinwhl.
    IPR002205. Topo_IIA_A/C.
    IPR013758. Topo_IIA_A/C_ab.
    IPR013760. Topo_IIA_like_dom.
    [Graphical view]
    PfamiPF03989. DNA_gyraseA_C. 6 hits.
    PF00521. DNA_topoisoIV. 1 hit.
    [Graphical view]
    SMARTiSM00434. TOP4c. 1 hit.
    [Graphical view]
    SUPFAMiSSF56719. SSF56719. 1 hit.
    TIGRFAMsiTIGR01063. gyrA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C5BUP9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTQPPETPDE RDAETTDAVV SAAGASALRD RVEQVDLQLE MQRSYLDYAM    50
    SVIVGRALPE VRDGLKPVHR RVLYAMFDGG YRPDSAFSKC ARVVGDVMGN 100
    YHPHGDTAIY DALVRLVQPW SMRYPLVAGQ GNFGSPGDDS AAAPRYTECK 150
    MAPLAMEMVR DIDKDTVDFG DNYDGRTQEP LILPARFPNL LVNGSAGIAV 200
    GMATNIPPHN LREVAEGVEW FLEHPDATNE ELLGALLLRI KGPDFPTGAQ 250
    ILGHRGIEDA YRTGRGSITM RAVVEVEEIQ GRQCLVVTEL PYQVNPDRLA 300
    AKIGEMVREG RISGIADLRD ETSGRAGQRL VIVLKRDAVA KVVLNNLYKH 350
    TQLQDTFGAN MLALVDGVPR TLSLDAFVRH WTMHQIDVIV RRTRYLLAED 400
    ERRIHILRGL LKALNALDEV IALIRRSPSS DEARTGLMEL LEIDEVQATA 450
    ILDMQLRRLA ALEQQRIMDE HAAIEARILD YQDILASEER QRSIVRSELG 500
    AIVERYGDER RTTILPFDGE MSVEDLIPEE DVVVTITRGG YAKRTRTDNY 550
    RAQRRGGKGV RGAQLREDDV VDHFFVTTTH HWLLFFTNLG RVYRAKGYEL 600
    PEGGRDAKGQ HVANLLAFQP GEKIAQVLAL RDYDQADYLV LATKRGLVKK 650
    TRLAEYDSSR TGGVIAINLR TDDGGAVDEV VSARIVGAED DLLLVSRKGQ 700
    SIRFTATDEA LRPMARATSG VTGMKFRADD ELLAMDVVET DADLFVVTEG 750
    GFAKRTALGE YRVQGRGGLG IKVANLVEAR GDLVGALVVD SDDEVLVIME 800
    RGKIVRSAVD EVTRTGRNTQ GVTFAKPDAG DRIIAIALGE ERAVADAGEE 850
    PVEESAEGAP TTDPAEGDGV PSSPEAAPEA EEGQA 885
    Length:885
    Mass (Da):97,172
    Last modified:July 28, 2009 - v1
    Checksum:i6CF4CDD25D407D2E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001618 Genomic DNA. Translation: ACQ78273.1.
    RefSeqiYP_002880035.1. NC_012669.1.

    Genome annotation databases

    EnsemblBacteriaiACQ78273; ACQ78273; Bcav_0007.
    GeneIDi7858207.
    KEGGibcv:Bcav_0007.
    PATRICi21090534. VBIBeuCav91323_0009.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001618 Genomic DNA. Translation: ACQ78273.1 .
    RefSeqi YP_002880035.1. NC_012669.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 471853.Bcav_0007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACQ78273 ; ACQ78273 ; Bcav_0007 .
    GeneIDi 7858207.
    KEGGi bcv:Bcav_0007.
    PATRICi 21090534. VBIBeuCav91323_0009.

    Phylogenomic databases

    eggNOGi COG0188.
    HOGENOMi HOG000076278.
    KOi K02469.
    OMAi PRYTECK.
    OrthoDBi EOG661H5V.

    Enzyme and pathway databases

    BioCyci BCAV471853:GI1Z-7-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1360.40. 1 hit.
    3.90.199.10. 2 hits.
    HAMAPi MF_01897. GyrA.
    InterProi IPR024946. Arg_repress_C-like.
    IPR005743. GyrA.
    IPR006691. GyrA/parC_pinwhl.
    IPR002205. Topo_IIA_A/C.
    IPR013758. Topo_IIA_A/C_ab.
    IPR013760. Topo_IIA_like_dom.
    [Graphical view ]
    Pfami PF03989. DNA_gyraseA_C. 6 hits.
    PF00521. DNA_topoisoIV. 1 hit.
    [Graphical view ]
    SMARTi SM00434. TOP4c. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56719. SSF56719. 1 hit.
    TIGRFAMsi TIGR01063. gyrA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-8 / DSM 12333 / NBRC 16432Imported.

    Entry informationi

    Entry nameiC5BUP9_BEUC1
    AccessioniPrimary (citable) accession number: C5BUP9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 28, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3