C5BRP6 (UPPP_TERTT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Ordered Locus Names:	TERTU_1199

Organism

Teredinibacter turnerae (strain ATCC 39867 / T7901) [Complete proteome] [HAMAP]

Taxonomic identifier

377629 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Alteromonadales genera incertae sedis › Teredinibacter › Teredinibacter turnerae

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 264	264	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_1000213161
Regions
	Transmembrane	1 – 21	21	Helical; Potential
	Transmembrane	39 – 59	21	Helical; Potential
	Transmembrane	87 – 107	21	Helical; Potential
	Transmembrane	111 – 131	21	Helical; Potential
	Transmembrane	144 – 164	21	Helical; Potential
	Transmembrane	187 – 207	21	Helical; Potential
	Transmembrane	208 – 228	21	Helical; Potential
	Transmembrane	244 – 264	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	C5BRP6 [UniParc]. Last modified July 28, 2009. Version 1. Checksum: BD3DECC4AD72921F	FASTA	264	28,271
	10 20 30 40 50 60 MDLIHVVVLA LIQGITEFLP ISSSAHLILP KEILGWPDQG LAFDVAVHVG TLTAVAVYFR 70 80 90 100 110 120 NDIGKIIIGW LSSVTGRGTD ESGRLGWYLI AATIPAALFG LIFDDLIETH LRSTDVIATT 130 140 150 160 170 180 TLVFGVLLWV ADRKPAETKQ LRDIALSTAM IIGLAQAVAL IPGTSRSGIT ITAALFLGLC 190 200 210 220 230 240 RTDAARFSFL LSIPVIVLSG GYKGLQLVLS AAAVDWLAIG LGIALSAVSA YICIHYFLNF 250 260 INRIGMLPFV IYRLLLGVLL FIAV

References

[1]

"The complete genome of Teredinibacter turnerae T7901: an intracellular endosymbiont of marine wood-boring bivalves (shipworms)." Yang J.C., Madupu R., Durkin A.S., Ekborg N.A., Pedamallu C.S., Hostetler J.B., Radune D., Toms B.S., Henrissat B., Coutinho P.M., Schwarz S., Field L., Trindade-Silva A.E., Soares C.A.G., Elshahawi S., Hanora A., Schmidt E.W., Haygood M.G. , Posfai J., Benner J., Madinger C., Nove J., Anton B., Chaudhary K., Foster J., Holman A., Kumar S., Lessard P.A., Luyten Y.A., Slatko B., Wood N., Wu B., Teplitski M., Mougous J.D., Ward N., Eisen J.A., Badger J.H., Distel D.L. PLoS ONE 4:E6085-E6085(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 39867 / T7901.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001614 Genomic DNA. Translation: ACR13919.1.
RefSeq	YP_003072776.1. NC_012997.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	377629.TERTU_1199.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACR13919; ACR13919; TERTU_1199.
GeneID	8213997.
KEGG	ttu:TERTU_1199.
PATRIC	23869571. VBITerTur118718_1130.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218357.
KO	K06153.
OMA	ITITTAR.
ProtClustDB	PRK00281.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP_TERTT

Accession

Primary (citable) accession number: C5BRP6

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	July 28, 2009
Last modified:	May 1, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program