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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Teredinibacter turnerae (strain ATCC 39867 / T7901)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:TERTU_1199
OrganismiTeredinibacter turnerae (strain ATCC 39867 / T7901)
Taxonomic identifieri377629 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaCellvibrionalesCellvibrionaceaeTeredinibacter
Proteomesi
  • UP000009080 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalUniRule annotationAdd BLAST21
Transmembranei39 – 59HelicalUniRule annotationAdd BLAST21
Transmembranei87 – 107HelicalUniRule annotationAdd BLAST21
Transmembranei111 – 131HelicalUniRule annotationAdd BLAST21
Transmembranei144 – 164HelicalUniRule annotationAdd BLAST21
Transmembranei187 – 207HelicalUniRule annotationAdd BLAST21
Transmembranei208 – 228HelicalUniRule annotationAdd BLAST21
Transmembranei244 – 264HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002131611 – 264Undecaprenyl-diphosphataseAdd BLAST264

Interactioni

Protein-protein interaction databases

STRINGi377629.TERTU_1199.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DWR. Bacteria.
COG1968. LUCA.
HOGENOMiHOG000218357.
KOiK06153.
OMAiAVMIYFR.
OrthoDBiPOG091H00ZR.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase. 1 hit.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

C5BRP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLIHVVVLA LIQGITEFLP ISSSAHLILP KEILGWPDQG LAFDVAVHVG
60 70 80 90 100
TLTAVAVYFR NDIGKIIIGW LSSVTGRGTD ESGRLGWYLI AATIPAALFG
110 120 130 140 150
LIFDDLIETH LRSTDVIATT TLVFGVLLWV ADRKPAETKQ LRDIALSTAM
160 170 180 190 200
IIGLAQAVAL IPGTSRSGIT ITAALFLGLC RTDAARFSFL LSIPVIVLSG
210 220 230 240 250
GYKGLQLVLS AAAVDWLAIG LGIALSAVSA YICIHYFLNF INRIGMLPFV
260
IYRLLLGVLL FIAV
Length:264
Mass (Da):28,271
Last modified:July 28, 2009 - v1
Checksum:iBD3DECC4AD72921F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001614 Genomic DNA. Translation: ACR13919.1.
RefSeqiWP_015820034.1. NC_012997.1.

Genome annotation databases

EnsemblBacteriaiACR13919; ACR13919; TERTU_1199.
KEGGittu:TERTU_1199.
PATRICi23869571. VBITerTur118718_1130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001614 Genomic DNA. Translation: ACR13919.1.
RefSeqiWP_015820034.1. NC_012997.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi377629.TERTU_1199.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACR13919; ACR13919; TERTU_1199.
KEGGittu:TERTU_1199.
PATRICi23869571. VBITerTur118718_1130.

Phylogenomic databases

eggNOGiENOG4105DWR. Bacteria.
COG1968. LUCA.
HOGENOMiHOG000218357.
KOiK06153.
OMAiAVMIYFR.
OrthoDBiPOG091H00ZR.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase. 1 hit.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUPPP_TERTT
AccessioniPrimary (citable) accession number: C5BRP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: November 2, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.