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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Teredinibacter turnerae (strain ATCC 39867 / T7901)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciTTUR377629:GHSU-651-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:TERTU_0724
OrganismiTeredinibacter turnerae (strain ATCC 39867 / T7901)
Taxonomic identifieri377629 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadales genera incertae sedisTeredinibacter
ProteomesiUP000009080: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 961961Glycine dehydrogenase (decarboxylating)PRO_1000212657Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei709 – 7091N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi377629.TERTU_0724.

Structurei

3D structure databases

ProteinModelPortaliC5BNY8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiHTQVDLM.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

C5BNY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNTDSLNNL FASDEFISRH IGPDQNQVEK MLATLEVDSL DALIEKTVPA
60 70 80 90 100
TIREAQPLPL AEPVAEHTAL EELKSLAAKN DVFTSYIGLG YHPTRVPNVI
110 120 130 140 150
LRNVLENPGW YTAYTPYQPE IAQGRLEGLL NFQQMITDLT GMEMANASML
160 170 180 190 200
DEATAAAEAM AMAKRVGRKN SSNCFFIDKN CYPQTIAVMR TRAEHFGFDI
210 220 230 240 250
IVDAPEKALA GEDYFGAILQ YPGADGGIGD IESWIKTIQS KDALAIVAAD
260 270 280 290 300
IMSLVLLRSP GDMGADIVIG CNQRFGIPMG FGGPHAAFFA FKEKHKRSTP
310 320 330 340 350
GRIIGVSVDS RGKQALRMAM QTREQHIRRE KANSNICTSQ VLLAVMSAFY
360 370 380 390 400
AMYHGAEGVD RIARRIHILT KMLSEGLISL GYKLRHTTFF DTLCIEVGDQ
410 420 430 440 450
QKPLLDRAQH ARINLCAMGS GALSISLSEC TTLDDLTALI AVFAGGESPL
460 470 480 490 500
DMPSLEAKAQ QKAVLSENLL RDGRALQHEI FSQYHSETEM LRYLKRLESR
510 520 530 540 550
DIALNHAMIP LGSCTMKLNA TAEMIPVTWP EFGNMHPFAP ISQAAGYAEM
560 570 580 590 600
FNQLQHMLAA CTGYDAISLQ PNAGSQGEYA GLLTIKKYFE AKGEVRSICL
610 620 630 640 650
IPQSAHGTNP ASAQMASMKV VVVNCDDDGN VDIADLDAKI AQHGENIAAI
660 670 680 690 700
MVTYPSTHGV FEENITQICD KIHAVGAQVY IDGANMNALV GIASPGHFGG
710 720 730 740 750
DVSHLNLHKT FCIPHGGGGP GMGPIGVKDH LAPYLAAHPL QEIPGTVAAN
760 770 780 790 800
GTVSAAPWGS ASILPISWMY IRMMGAKGMK MASEYAILNA NYIAKRLKNH
810 820 830 840 850
FPILYSGKHG FVAHECLLDL RPLKEASGVS EEDIAKRLMD FGFHAPTMSF
860 870 880 890 900
PVAGTLMIEP TESENQFELD RFCDAMIQIR EEIRKIEQGE LPADDNPLVN
910 920 930 940 950
APHTLDDVCN SEWNRSYTRD QACRPLDYLK HHKVWPTVNR IDNVYGDRNL
960
ICSCPGVDDY R
Length:961
Mass (Da):105,239
Last modified:July 28, 2009 - v1
Checksum:i4F241C8877C56485
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001614 Genomic DNA. Translation: ACR13967.1.
RefSeqiYP_003072346.1. NC_012997.1.

Genome annotation databases

EnsemblBacteriaiACR13967; ACR13967; TERTU_0724.
GeneIDi8210889.
KEGGittu:TERTU_0724.
PATRICi23868641. VBITerTur118718_0678.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001614 Genomic DNA. Translation: ACR13967.1.
RefSeqiYP_003072346.1. NC_012997.1.

3D structure databases

ProteinModelPortaliC5BNY8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi377629.TERTU_0724.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACR13967; ACR13967; TERTU_0724.
GeneIDi8210889.
KEGGittu:TERTU_0724.
PATRICi23868641. VBITerTur118718_0678.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiHTQVDLM.
OrthoDBiEOG6HMXDX.

Enzyme and pathway databases

BioCyciTTUR377629:GHSU-651-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39867 / T7901.

Entry informationi

Entry nameiGCSP_TERTT
AccessioniPrimary (citable) accession number: C5BNY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: March 4, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.