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C5BNY8 (GCSP_TERTT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:TERTU_0724
OrganismTeredinibacter turnerae (strain ATCC 39867 / T7901) [Complete proteome] [HAMAP]
Taxonomic identifier377629 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadales genera incertae sedisTeredinibacter

Protein attributes

Sequence length961 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 961961Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000212657

Amino acid modifications

Modified residue7091N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
C5BNY8 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 4F241C8877C56485

FASTA961105,239
        10         20         30         40         50         60 
MPNTDSLNNL FASDEFISRH IGPDQNQVEK MLATLEVDSL DALIEKTVPA TIREAQPLPL 

        70         80         90        100        110        120 
AEPVAEHTAL EELKSLAAKN DVFTSYIGLG YHPTRVPNVI LRNVLENPGW YTAYTPYQPE 

       130        140        150        160        170        180 
IAQGRLEGLL NFQQMITDLT GMEMANASML DEATAAAEAM AMAKRVGRKN SSNCFFIDKN 

       190        200        210        220        230        240 
CYPQTIAVMR TRAEHFGFDI IVDAPEKALA GEDYFGAILQ YPGADGGIGD IESWIKTIQS 

       250        260        270        280        290        300 
KDALAIVAAD IMSLVLLRSP GDMGADIVIG CNQRFGIPMG FGGPHAAFFA FKEKHKRSTP 

       310        320        330        340        350        360 
GRIIGVSVDS RGKQALRMAM QTREQHIRRE KANSNICTSQ VLLAVMSAFY AMYHGAEGVD 

       370        380        390        400        410        420 
RIARRIHILT KMLSEGLISL GYKLRHTTFF DTLCIEVGDQ QKPLLDRAQH ARINLCAMGS 

       430        440        450        460        470        480 
GALSISLSEC TTLDDLTALI AVFAGGESPL DMPSLEAKAQ QKAVLSENLL RDGRALQHEI 

       490        500        510        520        530        540 
FSQYHSETEM LRYLKRLESR DIALNHAMIP LGSCTMKLNA TAEMIPVTWP EFGNMHPFAP 

       550        560        570        580        590        600 
ISQAAGYAEM FNQLQHMLAA CTGYDAISLQ PNAGSQGEYA GLLTIKKYFE AKGEVRSICL 

       610        620        630        640        650        660 
IPQSAHGTNP ASAQMASMKV VVVNCDDDGN VDIADLDAKI AQHGENIAAI MVTYPSTHGV 

       670        680        690        700        710        720 
FEENITQICD KIHAVGAQVY IDGANMNALV GIASPGHFGG DVSHLNLHKT FCIPHGGGGP 

       730        740        750        760        770        780 
GMGPIGVKDH LAPYLAAHPL QEIPGTVAAN GTVSAAPWGS ASILPISWMY IRMMGAKGMK 

       790        800        810        820        830        840 
MASEYAILNA NYIAKRLKNH FPILYSGKHG FVAHECLLDL RPLKEASGVS EEDIAKRLMD 

       850        860        870        880        890        900 
FGFHAPTMSF PVAGTLMIEP TESENQFELD RFCDAMIQIR EEIRKIEQGE LPADDNPLVN 

       910        920        930        940        950        960 
APHTLDDVCN SEWNRSYTRD QACRPLDYLK HHKVWPTVNR IDNVYGDRNL ICSCPGVDDY 


R 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001614 Genomic DNA. Translation: ACR13967.1.
RefSeqYP_003072346.1. NC_012997.1.

3D structure databases

ProteinModelPortalC5BNY8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING377629.TERTU_0724.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACR13967; ACR13967; TERTU_0724.
GeneID8210889.
KEGGttu:TERTU_0724.
PATRIC23868641. VBITerTur118718_0678.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMATAYLTHP.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycTTUR377629:GHSU-651-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_TERTT
AccessionPrimary (citable) accession number: C5BNY8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: May 14, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families