C5BMA3 (TYSY_TERTT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidylate synthase
Short name=TS
Short name=TSase
EC=2.1.1.45

Gene names

Name:	thyA
Ordered Locus Names:	TERTU_0365

Organism

Teredinibacter turnerae (strain ATCC 39867 / T7901) [Complete proteome] [HAMAP]

Taxonomic identifier

377629 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Alteromonadales genera incertae sedis › Teredinibacter › Teredinibacter turnerae

Protein attributes

Sequence length	277 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Provides the sole de novo source of dTMP for DNA biosynthesis By similarity. HAMAP-Rule MF_00008
Catalytic activity	5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. HAMAP-Rule MF_00008
Pathway	Pyrimidine metabolism; dTTP biosynthesis. HAMAP-Rule MF_00008
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Cellular component	Cytoplasm
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dTMP biosynthetic process Inferred from electronic annotation. Source: HAMAP dTTP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	thymidylate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 277	277	Thymidylate synthase HAMAP-Rule MF_00008		PRO_1000201725
Sites
	Active site	159	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	C5BMA3 [UniParc]. Last modified July 28, 2009. Version 1. Checksum: B240560070F3720C	FASTA	277	31,412
	10 20 30 40 50 60 MKQYLELMRH VRDNGVRKED RTGTGTVSVF GYQMRFDLSQ GFPLVTTKKC HLKSIIHELL 70 80 90 100 110 120 WFLNGETNIA YLNNNGVKIW DAWATESGDL GPIYGAQWRS WPAQNGETLD QISQLIEQIK 130 140 150 160 170 180 HKPDSRRLII SAWNPALLPD ESISPQDNVR NGKMALPPCH TLFQFYVLEG RLSCQLYQRS 190 200 210 220 230 240 ADIFLGVPFN IASYALLTMM IAQVTGLAPG DFVHTFGDAH LYLNHLEQVD TQLQRQPLPL 250 260 270 PTMAINPAVK DIFGFCFDDF ELQNYQAHPH IAAPISV

References

[1]

"The complete genome of Teredinibacter turnerae T7901: an intracellular endosymbiont of marine wood-boring bivalves (shipworms)." Yang J.C., Madupu R., Durkin A.S., Ekborg N.A., Pedamallu C.S., Hostetler J.B., Radune D., Toms B.S., Henrissat B., Coutinho P.M., Schwarz S., Field L., Trindade-Silva A.E., Soares C.A.G., Elshahawi S., Hanora A., Schmidt E.W., Haygood M.G. , Posfai J., Benner J., Madinger C., Nove J., Anton B., Chaudhary K., Foster J., Holman A., Kumar S., Lessard P.A., Luyten Y.A., Slatko B., Wood N., Wu B., Teplitski M., Mougous J.D., Ward N., Eisen J.A., Badger J.H., Distel D.L. PLoS ONE 4:E6085-E6085(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 39867 / T7901.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001614 Genomic DNA. Translation: ACR13608.1.
RefSeq	YP_003072026.1. NC_012997.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	377629.TERTU_0365.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACR13608; ACR13608; TERTU_0365.
GeneID	8212100.
KEGG	ttu:TERTU_0365.
PATRIC	23867959. VBITerTur118718_0342.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0207.
HOGENOM	HOG000257900.
KO	K00560.
OMA	DTNVAYL.
ProtClustDB	PRK01827.
Enzyme and pathway databases
UniPathway	UPA00575.
Family and domain databases
Gene3D	3.30.572.10. 1 hit.
HAMAP	MF_00008. Thymidy_synth_bact.
InterPro	IPR023451. Thymidate_synth/dCMP_Mease. IPR000398. Thymidylate_synthase. [Graphical view]
Pfam	PF00303. Thymidylat_synt. 1 hit. [Graphical view]
PRINTS	PR00108. THYMDSNTHASE.
SUPFAM	SSF55831. Thymidylat_synth_C. 1 hit.
TIGRFAMs	TIGR03284. thym_sym. 2 hits.
PROSITE	PS00091. THYMIDYLATE_SYNTHASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYSY_TERTT

Accession

Primary (citable) accession number: C5BMA3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	July 28, 2009
Last modified:	May 1, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program