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C5BL73 (GCH1_TERTT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I
Gene names
Name:folE
Ordered Locus Names:TERTU_2509
OrganismTeredinibacter turnerae (strain ATCC 39867 / T7901) [Complete proteome] [HAMAP]
Taxonomic identifier377629 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadales genera incertae sedisTeredinibacter

Protein attributes

Sequence length184 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Subunit structure

Homopolymer By similarity. HAMAP-Rule MF_00223

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 184184GTP cyclohydrolase 1 HAMAP-Rule MF_00223
PRO_1000204300

Sites

Metal binding751Zinc By similarity
Metal binding781Zinc By similarity
Metal binding1461Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
C5BL73 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 5FDD629EED16F39E

FASTA18420,084
        10         20         30         40         50         60 
MKPTPAELYA NLISSTGEDL QRPGLQGTPA RAATAFEYLT SGYKQSVQEV VNDALFPSDS 

        70         80         90        100        110        120 
NDMVVVRDIE LFSLCEHHML PFIGKAHVGY IPTGKVLGLS KVARIIDMYA RRLQIQEQLT 

       130        140        150        160        170        180 
HQVASTIAEV TGAAGVGVII EAKHLCMMMR GVEKQNSVMK TSAMLGSFRA NLSTRSEFLA 


LLNN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001614 Genomic DNA. Translation: ACR12140.1.
RefSeqYP_003073938.1. NC_012997.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING377629.TERTU_2509.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACR12140; ACR12140; TERTU_2509.
GeneID8211401.
KEGGttu:TERTU_2509.
PATRIC23872003. VBITerTur118718_2333.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0302.
HOGENOMHOG000221222.
KOK01495.
OMAVYSHCEH.
OrthoDBEOG6XHC8G.

Enzyme and pathway databases

BioCycTTUR377629:GHSU-2270-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsTIGR00063. folE. 1 hit.
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH1_TERTT
AccessionPrimary (citable) accession number: C5BL73
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: May 14, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways