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C5BL09

- NADK_TERTT

UniProt

C5BL09 - NADK_TERTT

Protein

NAD kinase

Gene

nadK

Organism
Teredinibacter turnerae (strain ATCC 39867 / T7901)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei72 – 721Proton acceptorUniRule annotation
    Binding sitei157 – 1571NADUniRule annotation
    Binding sitei174 – 1741NADUniRule annotation
    Binding sitei176 – 1761NADUniRule annotation
    Binding sitei247 – 2471NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi72 – 732NADUniRule annotation
    Nucleotide bindingi146 – 1472NADUniRule annotation
    Nucleotide bindingi187 – 1926NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTTUR377629:GHSU-2205-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:TERTU_2444
    OrganismiTeredinibacter turnerae (strain ATCC 39867 / T7901)
    Taxonomic identifieri377629 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadales genera incertae sedisTeredinibacter
    ProteomesiUP000009080: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 293293NAD kinasePRO_1000205431Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi377629.TERTU_2444.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227221.
    KOiK00858.
    OMAiGAEFCLN.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C5BL09-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQSFNTIGLI GRLASASTQY SLKRLIAFLT DQKLEVLLDK ETSTILPDCD    50
    LPVATRPELA QACDLIIVVG GDGSLLSAAR AFAGHDVQIL GINRGRLGFL 100
    TDISPEDIEN KVGEVLSGRY LLEQRFLLES TLLRDDEVMS TGLALNDVVI 150
    HPGKLIRMIE FELYIDDEFV YRQRSDGLII SSPTGSTAYA LSGGGPIMHP 200
    NLDAVVLVPL YPHTLSSRPI VVGGNSEIRL IVCENNNLNP LVTCDGQSQT 250
    MTQPGDTVFI TKSEKRLKLI HPEGHNFYET CRSKLGWASH TGN 293
    Length:293
    Mass (Da):32,048
    Last modified:July 28, 2009 - v1
    Checksum:i876A2DAC896EF27E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001614 Genomic DNA. Translation: ACR14005.1.
    RefSeqiYP_003073873.1. NC_012997.1.

    Genome annotation databases

    EnsemblBacteriaiACR14005; ACR14005; TERTU_2444.
    GeneIDi8212924.
    KEGGittu:TERTU_2444.
    PATRICi23871871. VBITerTur118718_2267.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001614 Genomic DNA. Translation: ACR14005.1 .
    RefSeqi YP_003073873.1. NC_012997.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 377629.TERTU_2444.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACR14005 ; ACR14005 ; TERTU_2444 .
    GeneIDi 8212924.
    KEGGi ttu:TERTU_2444.
    PATRICi 23871871. VBITerTur118718_2267.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227221.
    KOi K00858.
    OMAi GAEFCLN.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci TTUR377629:GHSU-2205-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39867 / T7901.

    Entry informationi

    Entry nameiNADK_TERTT
    AccessioniPrimary (citable) accession number: C5BL09
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3