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Protein

Cobalt-precorrin-5B C(1)-methyltransferase

Gene

cbiD

Organism
Edwardsiella ictaluri (strain 93-146)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.UniRule annotation

Catalytic activityi

Cobalt-precorrin-5B + S-adenosyl-L-methionine = cobalt-precorrin-6A + S-adenosyl-L-homocysteine.UniRule annotation

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route).UniRule annotation
Proteins known to be involved in the 10 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. Cobalt-precorrin-5B C(1)-methyltransferase (cbiD)
  7. no protein annotated in this organism
  8. no protein annotated in this organism
  9. no protein annotated in this organism
  10. Cobyrinate a,c-diamide synthase (cbiA)
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route), the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processCobalamin biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00148; UER00227.

Names & Taxonomyi

Protein namesi
Recommended name:
Cobalt-precorrin-5B C(1)-methyltransferaseUniRule annotation (EC:2.1.1.195UniRule annotation)
Alternative name(s):
Cobalt-precorrin-6A synthaseUniRule annotation
Gene namesi
Name:cbiDUniRule annotation
Ordered Locus Names:NT01EI_2190
OrganismiEdwardsiella ictaluri (strain 93-146)
Taxonomic identifieri634503 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesHafniaceaeEdwardsiella
Proteomesi
  • UP000001485 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002129361 – 379Cobalt-precorrin-5B C(1)-methyltransferaseAdd BLAST379

Interactioni

Protein-protein interaction databases

STRINGi634503.NT01EI_2190.

Structurei

3D structure databases

SMRiC5BFT8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CbiD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EE8. Bacteria.
COG1903. LUCA.
HOGENOMiHOG000009126.
KOiK02188.
OMAiMMVHSKS.
OrthoDBiPOG091H02QJ.

Family and domain databases

HAMAPiMF_00787. CbiD. 1 hit.
InterProiView protein in InterPro
IPR002748. CbiD.
PANTHERiPTHR35863. PTHR35863. 1 hit.
PfamiView protein in Pfam
PF01888. CbiD. 1 hit.
PIRSFiPIRSF026782. CbiD. 1 hit.
SUPFAMiSSF111342. SSF111342. 1 hit.
TIGRFAMsiTIGR00312. cbiD. 1 hit.

Sequencei

Sequence statusi: Complete.

C5BFT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDRAFDTPV WHHGKALRKG YTTGSCATAA AKVAALMALR QQPIHQIAIV
60 70 80 90 100
TPSGVTLNLS VESPHIEGEQ AIAAIRKDGG DDVDATHGML IFARVTLNDS
110 120 130 140 150
GAISLSGGEG IGTVTRKGIG LPIGSAAINR TPRHTIESAV REAIGPTRGA
160 170 180 190 200
AVEIFAPEGV ARAQKTYNAR LGILGGISII GTTGIVTPMS EESWKRSLAL
210 220 230 240 250
TLEMKRAAGM TRVVLVPGNH GERFVREQMG IAADAVVTMS NFVGYMVEEA
260 270 280 290 300
VRLGFRQIVL VGHPGKLIKV AAGIFHTHSH MADARMETLV AHLALLGAPL
310 320 330 340 350
ALLTRVRDCD TTEAAMEHID AYGFQSLYDH LAARICQRVI ERLRFTQNLP
360 370
ICDAILFSFD NRTLGSNRPV AAIVEDLRC
Length:379
Mass (Da):40,550
Last modified:July 28, 2009 - v1
Checksum:iCD0436662E9631F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001600 Genomic DNA. Translation: ACR69365.1.
RefSeqiWP_015871491.1. NC_012779.2.

Genome annotation databases

EnsemblBacteriaiACR69365; ACR69365; NT01EI_2190.
GeneIDi7961623.
KEGGieic:NT01EI_2190.
PATRICi21837332. VBIEdwIct114273_1955.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001600 Genomic DNA. Translation: ACR69365.1.
RefSeqiWP_015871491.1. NC_012779.2.

3D structure databases

SMRiC5BFT8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi634503.NT01EI_2190.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACR69365; ACR69365; NT01EI_2190.
GeneIDi7961623.
KEGGieic:NT01EI_2190.
PATRICi21837332. VBIEdwIct114273_1955.

Phylogenomic databases

eggNOGiENOG4105EE8. Bacteria.
COG1903. LUCA.
HOGENOMiHOG000009126.
KOiK02188.
OMAiMMVHSKS.
OrthoDBiPOG091H02QJ.

Enzyme and pathway databases

UniPathwayiUPA00148; UER00227.

Family and domain databases

HAMAPiMF_00787. CbiD. 1 hit.
InterProiView protein in InterPro
IPR002748. CbiD.
PANTHERiPTHR35863. PTHR35863. 1 hit.
PfamiView protein in Pfam
PF01888. CbiD. 1 hit.
PIRSFiPIRSF026782. CbiD. 1 hit.
SUPFAMiSSF111342. SSF111342. 1 hit.
TIGRFAMsiTIGR00312. cbiD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCBID_EDWI9
AccessioniPrimary (citable) accession number: C5BFT8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: March 15, 2017
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.