Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cardiolipin synthase A

Gene

clsA

Organism
Edwardsiella ictaluri (strain 93-146)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.UniRule annotation

Catalytic activityi

2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei224UniRule annotation1
Active sitei226UniRule annotation1
Active sitei231UniRule annotation1
Active sitei404UniRule annotation1
Active sitei406UniRule annotation1
Active sitei411UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciEICT634503:G1GVC-1538-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiolipin synthase AUniRule annotation (EC:2.7.8.-UniRule annotation)
Short name:
CL synthaseUniRule annotation
Gene namesi
Name:clsAUniRule annotation
Synonyms:cls
Ordered Locus Names:NT01EI_1674
OrganismiEdwardsiella ictaluri (strain 93-146)
Taxonomic identifieri634503 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesHafniaceaeEdwardsiella
Proteomesi
  • UP000001485 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalUniRule annotationAdd BLAST21
Transmembranei38 – 58HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002039941 – 486Cardiolipin synthase AAdd BLAST486

Proteomic databases

PRIDEiC5BDA3

Interactioni

Protein-protein interaction databases

STRINGi634503.NT01EI_1674

Structurei

3D structure databases

ProteinModelPortaliC5BDA3
SMRiC5BDA3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini219 – 246PLD phosphodiesterase 1UniRule annotationAdd BLAST28
Domaini399 – 426PLD phosphodiesterase 2UniRule annotationAdd BLAST28

Sequence similaritiesi

Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CQX Bacteria
COG1502 LUCA
HOGENOMiHOG000077403
KOiK06131
OMAiGGHNVGD
OrthoDBiPOG091H04OR

Family and domain databases

HAMAPiMF_00190 Cardiolipin_synth_ClsA, 1 hit
InterProiView protein in InterPro
IPR022924 Cardiolipin_synthase
IPR030840 CL_synthase_A
IPR027379 CLS_N
IPR025202 PLD-like_dom
IPR001736 PLipase_D/transphosphatidylase
PfamiView protein in Pfam
PF13091 PLDc_2, 2 hits
PF13396 PLDc_N, 1 hit
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
TIGRFAMsiTIGR04265 bac_cardiolipin, 1 hit
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits

Sequencei

Sequence statusi: Complete.

C5BDA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTFYTVISW LAIFGYWLLI ASVTLRILMK RRAVPSAMAW LLIIYILPLV
60 70 80 90 100
GIIAYLSFGE LHLGKRRAER ARTMWPSTAR WLADLRSCRS IFATHNSEVA
110 120 130 140 150
APLFQLCERR QGIAGVKGNQ LQLLTSTDDT LNALIRDIEL AHTSIEMMFY
160 170 180 190 200
IWQPGGLADR VAEAMMAAAR RGIRCRLMLD SAGSVAFFRS PYPAMMREAG
210 220 230 240 250
IEVVEALQVN LLRVFLRRMD LRQHRKVVLI DNFIAYTGSM NLVDPRYFKQ
260 270 280 290 300
DAGVGQWIDV MARMEGPVAT TMGIYYAFDW EMETGKRILP PEPICNILPF
310 320 330 340 350
EKESGHTIQV IASGPGFPEE LIHQSLLTAV YSARQQLVMT TPYFVPSDDL
360 370 380 390 400
LHAICTAAQR GVDVSIIVPK KNDSMMVGWA SRAFFTEMLA AGVKIYQFEG
410 420 430 440 450
GLLHTKSVLV DGQLSLVGTV NLDMRSLWLN FEITLVIDDD GFGSDLACVQ
460 470 480
EDYIARSSLL DPLEWLKRPL WQRVVERLFY FFSPLL
Length:486
Mass (Da):54,966
Last modified:July 28, 2009 - v1
Checksum:iAEC40B754C68430A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001600 Genomic DNA Translation: ACR68855.1
RefSeqiWP_015871011.1, NC_012779.2

Genome annotation databases

EnsemblBacteriaiACR68855; ACR68855; NT01EI_1674
GeneIDi7958907
KEGGieic:NT01EI_1674
PATRICifig|634503.3.peg.1500

Similar proteinsi

Entry informationi

Entry nameiCLSA_EDWI9
AccessioniPrimary (citable) accession number: C5BDA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: May 23, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health