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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Edwardsiella ictaluri (strain 93-146)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (pncB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, Transferase
Biological processPyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciEICT634503:G1GVC-1257-MONOMER
UniPathwayiUPA00253; UER00457

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:NT01EI_1361
OrganismiEdwardsiella ictaluri (strain 93-146)
Taxonomic identifieri634503 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesHafniaceaeEdwardsiella
Proteomesi
  • UP000001485 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002120841 – 401Nicotinate phosphoribosyltransferaseAdd BLAST401

Interactioni

Protein-protein interaction databases

STRINGi634503.NT01EI_1361

Structurei

3D structure databases

ProteinModelPortaliC5BD56
SMRiC5BD56
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RH7 Bacteria
COG1488 LUCA
HOGENOMiHOG000284928
KOiK00763
OMAiKLTMQCA
OrthoDBiPOG091H0197

Family and domain databases

CDDicd01401 PncB_like, 1 hit
HAMAPiMF_00570 NAPRTase, 1 hit
InterProiView protein in InterPro
IPR006406 Nic_PRibTrfase
IPR007229 Nic_PRibTrfase-Fam
IPR036068 Nicotinate_pribotase_like_C
PANTHERiPTHR11098 PTHR11098, 1 hit
PfamiView protein in Pfam
PF04095 NAPRTase, 1 hit
PIRSFiPIRSF000484 NAPRT, 1 hit
SUPFAMiSSF51690 SSF51690, 1 hit
TIGRFAMsiTIGR01514 NAPRTase, 1 hit

Sequencei

Sequence statusi: Complete.

C5BD56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQDVSPIIT SLLDTDAYKL HMQQAVYHRY RNVSVAAEFR CRGDELLGEY
60 70 80 90 100
AGEIANQVNL MGQLALTQDE YDYLAALPFF QRDYLDWLRT LRLDPRRVAI
110 120 130 140 150
SNDRGRLNIR ISGPWREVIL WEVPLLAVIS EVVHRHRSPH ITPEVAAAQL
160 170 180 190 200
QRRLSEFRHL SADVDLRGFH LIDFGTRRRF SRAVHQAILT TLKSEFPYLS
210 220 230 240 250
GTSNYLFAKQ MALTPLGTQA HEWFQAHQQI CPVLANSQRA ALQSWLDEYP
260 270 280 290 300
DQLGIALTDC ITMDAFLRDF GSQFAGHYQG LRHDSGDPIA WGEKAIAHYE
310 320 330 340 350
QLGLDPQDKM LVFSDNLDLP KALALYRHFH HRINLSFGIG TRLTCDLPGV
360 370 380 390 400
RPLNIVIKLV ECNGKPVAKL SDSPGKTICQ DAAFVKALRK AFDLPLVKRA

S
Length:401
Mass (Da):45,538
Last modified:July 28, 2009 - v1
Checksum:i6CC3CEA4DB8DE6DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001600 Genomic DNA Translation: ACR68551.1
RefSeqiWP_015870716.1, NC_012779.2

Genome annotation databases

EnsemblBacteriaiACR68551; ACR68551; NT01EI_1361
GeneIDi7960444
KEGGieic:NT01EI_1361
PATRICifig|634503.3.peg.1224

Similar proteinsi

Entry informationi

Entry nameiPNCB_EDWI9
AccessioniPrimary (citable) accession number: C5BD56
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: April 25, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health