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C5BCH5

- RISB_EDWI9

UniProt

C5BCH5 - RISB_EDWI9

Protein

6,7-dimethyl-8-ribityllumazine synthase

Gene

ribH

Organism
Edwardsiella ictaluri (strain 93-146)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.UniRule annotation

    Catalytic activityi

    1-deoxy-L-glycero-tetrulose 4-phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(D-ribityl)lumazine + 2 H2O + phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei22 – 2215-amino-6-(D-ribitylamino)uracilUniRule annotation
    Active sitei89 – 891Proton donorUniRule annotation
    Binding sitei114 – 11415-amino-6-(D-ribitylamino)uracil; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei128 – 12811-deoxy-L-glycero-tetrulose 4-phosphateUniRule annotation

    GO - Molecular functioni

    1. 6,7-dimethyl-8-ribityllumazine synthase activity Source: UniProtKB-HAMAP
    2. transferase activity Source: UniProtKB-KW

    GO - Biological processi

    1. riboflavin biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Riboflavin biosynthesis

    Enzyme and pathway databases

    BioCyciEICT634503:GCMY-1046-MONOMER.
    UniPathwayiUPA00275; UER00404.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6,7-dimethyl-8-ribityllumazine synthaseUniRule annotation (EC:2.5.1.78UniRule annotation)
    Short name:
    DMRL synthaseUniRule annotation
    Short name:
    LSUniRule annotation
    Short name:
    Lumazine synthaseUniRule annotation
    Gene namesi
    Name:ribHUniRule annotation
    Ordered Locus Names:NT01EI_1057
    OrganismiEdwardsiella ictaluri (strain 93-146)
    Taxonomic identifieri634503 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEdwardsiella
    ProteomesiUP000001485: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. riboflavin synthase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 1561566,7-dimethyl-8-ribityllumazine synthasePRO_1000203790Add
    BLAST

    Proteomic databases

    PRIDEiC5BCH5.

    Interactioni

    Subunit structurei

    Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.UniRule annotation

    Protein-protein interaction databases

    STRINGi634503.NT01EI_1057.

    Structurei

    3D structure databases

    ProteinModelPortaliC5BCH5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni57 – 5935-amino-6-(D-ribitylamino)uracil bindingUniRule annotation
    Regioni81 – 8335-amino-6-(D-ribitylamino)uracil bindingUniRule annotation
    Regioni86 – 8721-deoxy-L-glycero-tetrulose 4-phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the DMRL synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0054.
    HOGENOMiHOG000229250.
    KOiK00794.
    OMAiISRFNDF.
    OrthoDBiEOG6RC3WC.

    Family and domain databases

    Gene3Di3.40.50.960. 1 hit.
    HAMAPiMF_00178. Lumazine_synth.
    InterProiIPR002180. DMRL_synthase.
    [Graphical view]
    PANTHERiPTHR21058. PTHR21058. 1 hit.
    PfamiPF00885. DMRL_synthase. 1 hit.
    [Graphical view]
    SUPFAMiSSF52121. SSF52121. 1 hit.
    TIGRFAMsiTIGR00114. lumazine-synth. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C5BCH5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTIQGVVAA PQARVAIAIS RFNHFINDSL LEGAIDALKR IGQVSDENIT    50
    VVWVPGAYEL PLTVRALASS GRYDAVVALG TVIRGGTAHF EFVAGECSSG 100
    LASVALNTDV PVAFGVLTTE TIEQAIDRAG AKAGNKGAEA ALTALEMINV 150
    LKAIKA 156
    Length:156
    Mass (Da):16,147
    Last modified:July 28, 2009 - v1
    Checksum:iEDD1FEFA5894EF20
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001600 Genomic DNA. Translation: ACR68269.1.
    RefSeqiYP_002932504.1. NC_012779.2.

    Genome annotation databases

    EnsemblBacteriaiACR68269; ACR68269; NT01EI_1057.
    GeneIDi7959440.
    KEGGieic:NT01EI_1057.
    PATRICi21835282. VBIEdwIct114273_0957.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001600 Genomic DNA. Translation: ACR68269.1 .
    RefSeqi YP_002932504.1. NC_012779.2.

    3D structure databases

    ProteinModelPortali C5BCH5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 634503.NT01EI_1057.

    Proteomic databases

    PRIDEi C5BCH5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACR68269 ; ACR68269 ; NT01EI_1057 .
    GeneIDi 7959440.
    KEGGi eic:NT01EI_1057.
    PATRICi 21835282. VBIEdwIct114273_0957.

    Phylogenomic databases

    eggNOGi COG0054.
    HOGENOMi HOG000229250.
    KOi K00794.
    OMAi ISRFNDF.
    OrthoDBi EOG6RC3WC.

    Enzyme and pathway databases

    UniPathwayi UPA00275 ; UER00404 .
    BioCyci EICT634503:GCMY-1046-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.960. 1 hit.
    HAMAPi MF_00178. Lumazine_synth.
    InterProi IPR002180. DMRL_synthase.
    [Graphical view ]
    PANTHERi PTHR21058. PTHR21058. 1 hit.
    Pfami PF00885. DMRL_synthase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52121. SSF52121. 1 hit.
    TIGRFAMsi TIGR00114. lumazine-synth. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Edwardsiella ictaluri 93-146."
      Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C., Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.
      Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 93-146.

    Entry informationi

    Entry nameiRISB_EDWI9
    AccessioniPrimary (citable) accession number: C5BCH5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3