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C5BCH5

- RISB_EDWI9

UniProt

C5BCH5 - RISB_EDWI9

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Protein

6,7-dimethyl-8-ribityllumazine synthase

Gene

ribH

Organism
Edwardsiella ictaluri (strain 93-146)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.UniRule annotation

Catalytic activityi

1-deoxy-L-glycero-tetrulose 4-phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(D-ribityl)lumazine + 2 H2O + phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei22 – 2215-amino-6-(D-ribitylamino)uracilUniRule annotation
Active sitei89 – 891Proton donorUniRule annotation
Binding sitei114 – 11415-amino-6-(D-ribitylamino)uracil; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei128 – 12811-deoxy-L-glycero-tetrulose 4-phosphateUniRule annotation

GO - Molecular functioni

  1. 6,7-dimethyl-8-ribityllumazine synthase activity Source: UniProtKB-HAMAP
  2. transferase activity Source: UniProtKB-KW

GO - Biological processi

  1. riboflavin biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Riboflavin biosynthesis

Enzyme and pathway databases

BioCyciEICT634503:GCMY-1046-MONOMER.
UniPathwayiUPA00275; UER00404.

Names & Taxonomyi

Protein namesi
Recommended name:
6,7-dimethyl-8-ribityllumazine synthaseUniRule annotation (EC:2.5.1.78UniRule annotation)
Short name:
DMRL synthaseUniRule annotation
Short name:
LSUniRule annotation
Short name:
Lumazine synthaseUniRule annotation
Gene namesi
Name:ribHUniRule annotation
Ordered Locus Names:NT01EI_1057
OrganismiEdwardsiella ictaluri (strain 93-146)
Taxonomic identifieri634503 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEdwardsiella
ProteomesiUP000001485: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. riboflavin synthase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1561566,7-dimethyl-8-ribityllumazine synthasePRO_1000203790Add
BLAST

Proteomic databases

PRIDEiC5BCH5.

Interactioni

Subunit structurei

Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.UniRule annotation

Protein-protein interaction databases

STRINGi634503.NT01EI_1057.

Structurei

3D structure databases

ProteinModelPortaliC5BCH5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni57 – 5935-amino-6-(D-ribitylamino)uracil bindingUniRule annotation
Regioni81 – 8335-amino-6-(D-ribitylamino)uracil bindingUniRule annotation
Regioni86 – 8721-deoxy-L-glycero-tetrulose 4-phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the DMRL synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0054.
HOGENOMiHOG000229250.
KOiK00794.
OMAiISRFNDF.
OrthoDBiEOG6RC3WC.

Family and domain databases

Gene3Di3.40.50.960. 1 hit.
HAMAPiMF_00178. Lumazine_synth.
InterProiIPR002180. DMRL_synthase.
[Graphical view]
PANTHERiPTHR21058. PTHR21058. 1 hit.
PfamiPF00885. DMRL_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF52121. SSF52121. 1 hit.
TIGRFAMsiTIGR00114. lumazine-synth. 1 hit.

Sequencei

Sequence statusi: Complete.

C5BCH5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTIQGVVAA PQARVAIAIS RFNHFINDSL LEGAIDALKR IGQVSDENIT
60 70 80 90 100
VVWVPGAYEL PLTVRALASS GRYDAVVALG TVIRGGTAHF EFVAGECSSG
110 120 130 140 150
LASVALNTDV PVAFGVLTTE TIEQAIDRAG AKAGNKGAEA ALTALEMINV

LKAIKA
Length:156
Mass (Da):16,147
Last modified:July 28, 2009 - v1
Checksum:iEDD1FEFA5894EF20
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001600 Genomic DNA. Translation: ACR68269.1.
RefSeqiWP_015870450.1. NC_012779.2.
YP_002932504.1. NC_012779.2.

Genome annotation databases

EnsemblBacteriaiACR68269; ACR68269; NT01EI_1057.
GeneIDi7959440.
KEGGieic:NT01EI_1057.
PATRICi21835282. VBIEdwIct114273_0957.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001600 Genomic DNA. Translation: ACR68269.1 .
RefSeqi WP_015870450.1. NC_012779.2.
YP_002932504.1. NC_012779.2.

3D structure databases

ProteinModelPortali C5BCH5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 634503.NT01EI_1057.

Proteomic databases

PRIDEi C5BCH5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACR68269 ; ACR68269 ; NT01EI_1057 .
GeneIDi 7959440.
KEGGi eic:NT01EI_1057.
PATRICi 21835282. VBIEdwIct114273_0957.

Phylogenomic databases

eggNOGi COG0054.
HOGENOMi HOG000229250.
KOi K00794.
OMAi ISRFNDF.
OrthoDBi EOG6RC3WC.

Enzyme and pathway databases

UniPathwayi UPA00275 ; UER00404 .
BioCyci EICT634503:GCMY-1046-MONOMER.

Family and domain databases

Gene3Di 3.40.50.960. 1 hit.
HAMAPi MF_00178. Lumazine_synth.
InterProi IPR002180. DMRL_synthase.
[Graphical view ]
PANTHERi PTHR21058. PTHR21058. 1 hit.
Pfami PF00885. DMRL_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF52121. SSF52121. 1 hit.
TIGRFAMsi TIGR00114. lumazine-synth. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Edwardsiella ictaluri 93-146."
    Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C., Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.
    Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 93-146.

Entry informationi

Entry nameiRISB_EDWI9
AccessioniPrimary (citable) accession number: C5BCH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: October 29, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3