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C5BCH5

- RISB_EDWI9

UniProt

C5BCH5 - RISB_EDWI9

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Protein
6,7-dimethyl-8-ribityllumazine synthase
Gene
ribH, NT01EI_1057
Organism
Edwardsiella ictaluri (strain 93-146)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin By similarity.UniRule annotation

Catalytic activityi

1-deoxy-L-glycero-tetrulose 4-phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(D-ribityl)lumazine + 2 H2O + phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei22 – 2215-amino-6-(D-ribitylamino)uracil By similarity
Active sitei89 – 891Proton donor Reviewed prediction
Binding sitei114 – 11415-amino-6-(D-ribitylamino)uracil; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei128 – 12811-deoxy-L-glycero-tetrulose 4-phosphate By similarity

GO - Molecular functioni

  1. 6,7-dimethyl-8-ribityllumazine synthase activity Source: UniProtKB-HAMAP
  2. transferase activity Source: UniProtKB-KW

GO - Biological processi

  1. riboflavin biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Riboflavin biosynthesis

Enzyme and pathway databases

BioCyciEICT634503:GCMY-1046-MONOMER.
UniPathwayiUPA00275; UER00404.

Names & Taxonomyi

Protein namesi
Recommended name:
6,7-dimethyl-8-ribityllumazine synthase (EC:2.5.1.78)
Short name:
DMRL synthase
Short name:
LS
Short name:
Lumazine synthase
Gene namesi
Name:ribH
Ordered Locus Names:NT01EI_1057
OrganismiEdwardsiella ictaluri (strain 93-146)
Taxonomic identifieri634503 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEdwardsiella
ProteomesiUP000001485: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. riboflavin synthase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1561566,7-dimethyl-8-ribityllumazine synthaseUniRule annotation
PRO_1000203790Add
BLAST

Proteomic databases

PRIDEiC5BCH5.

Interactioni

Subunit structurei

Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers By similarity.

Protein-protein interaction databases

STRINGi634503.NT01EI_1057.

Structurei

3D structure databases

ProteinModelPortaliC5BCH5.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni57 – 5935-amino-6-(D-ribitylamino)uracil binding By similarity
Regioni81 – 8335-amino-6-(D-ribitylamino)uracil binding By similarity
Regioni86 – 8721-deoxy-L-glycero-tetrulose 4-phosphate binding By similarity

Sequence similaritiesi

Belongs to the DMRL synthase family.

Phylogenomic databases

eggNOGiCOG0054.
HOGENOMiHOG000229250.
KOiK00794.
OMAiISRFNDF.
OrthoDBiEOG6RC3WC.

Family and domain databases

Gene3Di3.40.50.960. 1 hit.
HAMAPiMF_00178. Lumazine_synth.
InterProiIPR002180. DMRL_synthase.
[Graphical view]
PANTHERiPTHR21058. PTHR21058. 1 hit.
PfamiPF00885. DMRL_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF52121. SSF52121. 1 hit.
TIGRFAMsiTIGR00114. lumazine-synth. 1 hit.

Sequencei

Sequence statusi: Complete.

C5BCH5-1 [UniParc]FASTAAdd to Basket

« Hide

MKTIQGVVAA PQARVAIAIS RFNHFINDSL LEGAIDALKR IGQVSDENIT    50
VVWVPGAYEL PLTVRALASS GRYDAVVALG TVIRGGTAHF EFVAGECSSG 100
LASVALNTDV PVAFGVLTTE TIEQAIDRAG AKAGNKGAEA ALTALEMINV 150
LKAIKA 156
Length:156
Mass (Da):16,147
Last modified:July 28, 2009 - v1
Checksum:iEDD1FEFA5894EF20
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001600 Genomic DNA. Translation: ACR68269.1.
RefSeqiYP_002932504.1. NC_012779.2.

Genome annotation databases

EnsemblBacteriaiACR68269; ACR68269; NT01EI_1057.
GeneIDi7959440.
KEGGieic:NT01EI_1057.
PATRICi21835282. VBIEdwIct114273_0957.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001600 Genomic DNA. Translation: ACR68269.1 .
RefSeqi YP_002932504.1. NC_012779.2.

3D structure databases

ProteinModelPortali C5BCH5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 634503.NT01EI_1057.

Proteomic databases

PRIDEi C5BCH5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACR68269 ; ACR68269 ; NT01EI_1057 .
GeneIDi 7959440.
KEGGi eic:NT01EI_1057.
PATRICi 21835282. VBIEdwIct114273_0957.

Phylogenomic databases

eggNOGi COG0054.
HOGENOMi HOG000229250.
KOi K00794.
OMAi ISRFNDF.
OrthoDBi EOG6RC3WC.

Enzyme and pathway databases

UniPathwayi UPA00275 ; UER00404 .
BioCyci EICT634503:GCMY-1046-MONOMER.

Family and domain databases

Gene3Di 3.40.50.960. 1 hit.
HAMAPi MF_00178. Lumazine_synth.
InterProi IPR002180. DMRL_synthase.
[Graphical view ]
PANTHERi PTHR21058. PTHR21058. 1 hit.
Pfami PF00885. DMRL_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF52121. SSF52121. 1 hit.
TIGRFAMsi TIGR00114. lumazine-synth. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Edwardsiella ictaluri 93-146."
    Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C., Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.
    Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 93-146.

Entry informationi

Entry nameiRISB_EDWI9
AccessioniPrimary (citable) accession number: C5BCH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: May 14, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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