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Protein

Agmatinase

Gene

speB

Organism
Edwardsiella ictaluri (strain 93-146)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of putrescine from agmatine.UniRule annotation

Catalytic activityi

Agmatine + H2O = putrescine + urea.UniRule annotation

Cofactori

Mn2+UniRule annotation

Pathwayi: putrescine biosynthesis via agmatine pathway

This protein is involved in step 1 of the subpathway that synthesizes putrescine from agmatine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Agmatinase (speB)
This subpathway is part of the pathway putrescine biosynthesis via agmatine pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes putrescine from agmatine, the pathway putrescine biosynthesis via agmatine pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi126ManganeseUniRule annotation1
Metal bindingi149ManganeseUniRule annotation1
Metal bindingi151ManganeseUniRule annotation1
Metal bindingi153ManganeseUniRule annotation1
Metal bindingi230ManganeseUniRule annotation1
Metal bindingi232ManganeseUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processPolyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciEICT634503:G1GVC-3078-MONOMER
UniPathwayiUPA00534; UER00287

Names & Taxonomyi

Protein namesi
Recommended name:
AgmatinaseUniRule annotation (EC:3.5.3.11UniRule annotation)
Alternative name(s):
Agmatine ureohydrolaseUniRule annotation
Short name:
AUHUniRule annotation
Gene namesi
Name:speBUniRule annotation
Ordered Locus Names:NT01EI_3373
OrganismiEdwardsiella ictaluri (strain 93-146)
Taxonomic identifieri634503 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesHafniaceaeEdwardsiella
Proteomesi
  • UP000001485 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002152511 – 304AgmatinaseAdd BLAST304

Interactioni

Protein-protein interaction databases

STRINGi634503.NT01EI_3373

Structurei

3D structure databases

ProteinModelPortaliC5BAV1
SMRiC5BAV1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arginase family. Agmatinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CYW Bacteria
COG0010 LUCA
HOGENOMiHOG000204320
KOiK01480
OMAiDTYFGAE
OrthoDBiPOG091H0384

Family and domain databases

HAMAPiMF_01418 SpeB, 1 hit
InterProiView protein in InterPro
IPR023694 Agmatinase
IPR005925 Agmatinase-rel
IPR006035 Ureohydrolase
IPR023696 Ureohydrolase_dom_sf
IPR020855 Ureohydrolase_Mn_BS
PfamiView protein in Pfam
PF00491 Arginase, 1 hit
PIRSFiPIRSF036979 Arginase, 1 hit
SUPFAMiSSF52768 SSF52768, 1 hit
TIGRFAMsiTIGR01230 agmatinase, 1 hit
PROSITEiView protein in PROSITE
PS01053 ARGINASE_1, 1 hit
PS51409 ARGINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

C5BAV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCTLGHKPDN SLVSNAFGFL RLPLDFMPYD GDADWVITGV PFDMATSGRA
60 70 80 90 100
GGRHGPAAIR QVSTNLAWEG KRWPWNFDMR DRLKVVDCGD VVFSFGDAQE
110 120 130 140 150
MSDNLQAHAE RLLASGKRCL TFGGDHFITL PLLRAHAKHF GKMALVHFDA
160 170 180 190 200
HTDTYAHGSK FDHGTMFFHA PNEGLIDPQH SVQIGIRTEY DHDNGFTVLD
210 220 230 240 250
AAQVNDRSVE DVLAEVKRIV GDLPVYLTFD IDCLDPAHAP GTGTPVIGGL
260 270 280 290 300
TSDRALKLVR GLQDLDIVGM DVVEVAPAYD QSEITALAAA TLALEMLYIQ

AAKK
Length:304
Mass (Da):33,259
Last modified:July 28, 2009 - v1
Checksum:iAAE0E85E97348D4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001600 Genomic DNA Translation: ACR70510.1
RefSeqiWP_015872583.1, NC_012779.2

Genome annotation databases

EnsemblBacteriaiACR70510; ACR70510; NT01EI_3373
GeneIDi7959672
KEGGieic:NT01EI_3373
PATRICifig|634503.3.peg.2999

Similar proteinsi

Entry informationi

Entry nameiSPEB_EDWI9
AccessioniPrimary (citable) accession number: C5BAV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: March 28, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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