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C5BAT0

- GCSP_EDWI9

UniProt

C5BAT0 - GCSP_EDWI9

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Edwardsiella ictaluri (strain 93-146)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciEICT634503:GCMY-3323-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:NT01EI_3351
    OrganismiEdwardsiella ictaluri (strain 93-146)
    Taxonomic identifieri634503 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEdwardsiella
    ProteomesiUP000001485: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 960960Glycine dehydrogenase (decarboxylating)PRO_1000212654Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei709 – 7091N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi634503.NT01EI_3351.

    Structurei

    3D structure databases

    ProteinModelPortaliC5BAT0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C5BAT0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTQTLTQLEN SDAFIARHIG PTPEEQQQML AQIGAADLDT LLARIVPADI    50
    QLPAAPPIGA ACSEQQALDE LRAIAAQNQC YRSFIGMGYY GVQTPPAIQR 100
    NMLENPGWYT AYTPYQPEVS QGRLEALLNF QQMTLDLTGL DLASASLLDE 150
    ATAAAEAMGL ARRASRLKQA NTFFIAQDVH PQTIDVVCTR AQSCGVEVII 200
    DDARRAADHR DLFGVLLQQV GTQGDLHDYR ALMDSLRERG VITCMAADPL 250
    ALVLLEAPGR QGADVVFGSA QRFGVPMGYG GPHAAFFACR EAFKRAMPGR 300
    IIGVARDAAG EPALRMAMQT REQHIRREKA NSNICTSQVL LANIAGMYAV 350
    YHGPQGLRRI AERVHRLADI LALGLQQKGV TLRNHCWFDT LTVAVPDKGA 400
    VLARALGFGI NLRGDLDGAV GISFDECSTR DDLEALFTIL LGDGHALDID 450
    TLDTLVQEAC EGSIPAALLR REPILTHPVF NRYHSETALM RYMHALERRD 500
    LALNQAMIPL GSCTMKLNAA AEMIPITWPE FAALHPFCPP EQAQGYRLLL 550
    SQLAEWLVQL TGYDAVCLQP NSGAQGEYAG LLAIRRYHES RGEGQRTRCL 600
    IPASAHGTNP ASAQMAGMEV EVVACDEQGN IDLHDLRERA RQAGERLAAI 650
    MVTYPSTHGV YEETIREVCQ IVHQYGGQVY LDGANMNAQV GITTPGYIGA 700
    DVSHLNLHKT FAIPHGGGGP GMGPIGVKAH LAPFVPGHRV VQLAGLTTRQ 750
    GAVSAAPFGS ASILPISWMY IRMMGAEGLR RASTVAILNA NYIARRLGAV 800
    YPVLYRGKEG YVAHECILDL RPLKARSGIS EMDIAKRLID YGFHAPTMSF 850
    PVAGTLMVEP TESENKAELD RFIAAMLAIH DEITRVETGE WPLQDNPLVN 900
    APHTQRELVG EWHHPYGREL AVFPTPQTRE NKYWPAVKRL DDVYGDRHLQ 950
    CSCPPLSDWA 960
    Length:960
    Mass (Da):104,902
    Last modified:July 28, 2009 - v1
    Checksum:iC429F74ED788B891
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001600 Genomic DNA. Translation: ACR70489.1.
    RefSeqiYP_002934724.1. NC_012779.2.

    Genome annotation databases

    EnsemblBacteriaiACR70489; ACR70489; NT01EI_3351.
    GeneIDi7959651.
    KEGGieic:NT01EI_3351.
    PATRICi21839436. VBIEdwIct114273_2978.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001600 Genomic DNA. Translation: ACR70489.1 .
    RefSeqi YP_002934724.1. NC_012779.2.

    3D structure databases

    ProteinModelPortali C5BAT0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 634503.NT01EI_3351.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACR70489 ; ACR70489 ; NT01EI_3351 .
    GeneIDi 7959651.
    KEGGi eic:NT01EI_3351.
    PATRICi 21839436. VBIEdwIct114273_2978.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci EICT634503:GCMY-3323-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Edwardsiella ictaluri 93-146."
      Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C., Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.
      Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 93-146.

    Entry informationi

    Entry nameiGCSP_EDWI9
    AccessioniPrimary (citable) accession number: C5BAT0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3