Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

C5BAT0 (GCSP_EDWI9) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:NT01EI_3351
OrganismEdwardsiella ictaluri (strain 93-146) [Complete proteome] [HAMAP]
Taxonomic identifier634503 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEdwardsiella

Protein attributes

Sequence length960 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 960960Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000212654

Amino acid modifications

Modified residue7091N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
C5BAT0 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: C429F74ED788B891

FASTA960104,902
        10         20         30         40         50         60 
MTQTLTQLEN SDAFIARHIG PTPEEQQQML AQIGAADLDT LLARIVPADI QLPAAPPIGA 

        70         80         90        100        110        120 
ACSEQQALDE LRAIAAQNQC YRSFIGMGYY GVQTPPAIQR NMLENPGWYT AYTPYQPEVS 

       130        140        150        160        170        180 
QGRLEALLNF QQMTLDLTGL DLASASLLDE ATAAAEAMGL ARRASRLKQA NTFFIAQDVH 

       190        200        210        220        230        240 
PQTIDVVCTR AQSCGVEVII DDARRAADHR DLFGVLLQQV GTQGDLHDYR ALMDSLRERG 

       250        260        270        280        290        300 
VITCMAADPL ALVLLEAPGR QGADVVFGSA QRFGVPMGYG GPHAAFFACR EAFKRAMPGR 

       310        320        330        340        350        360 
IIGVARDAAG EPALRMAMQT REQHIRREKA NSNICTSQVL LANIAGMYAV YHGPQGLRRI 

       370        380        390        400        410        420 
AERVHRLADI LALGLQQKGV TLRNHCWFDT LTVAVPDKGA VLARALGFGI NLRGDLDGAV 

       430        440        450        460        470        480 
GISFDECSTR DDLEALFTIL LGDGHALDID TLDTLVQEAC EGSIPAALLR REPILTHPVF 

       490        500        510        520        530        540 
NRYHSETALM RYMHALERRD LALNQAMIPL GSCTMKLNAA AEMIPITWPE FAALHPFCPP 

       550        560        570        580        590        600 
EQAQGYRLLL SQLAEWLVQL TGYDAVCLQP NSGAQGEYAG LLAIRRYHES RGEGQRTRCL 

       610        620        630        640        650        660 
IPASAHGTNP ASAQMAGMEV EVVACDEQGN IDLHDLRERA RQAGERLAAI MVTYPSTHGV 

       670        680        690        700        710        720 
YEETIREVCQ IVHQYGGQVY LDGANMNAQV GITTPGYIGA DVSHLNLHKT FAIPHGGGGP 

       730        740        750        760        770        780 
GMGPIGVKAH LAPFVPGHRV VQLAGLTTRQ GAVSAAPFGS ASILPISWMY IRMMGAEGLR 

       790        800        810        820        830        840 
RASTVAILNA NYIARRLGAV YPVLYRGKEG YVAHECILDL RPLKARSGIS EMDIAKRLID 

       850        860        870        880        890        900 
YGFHAPTMSF PVAGTLMVEP TESENKAELD RFIAAMLAIH DEITRVETGE WPLQDNPLVN 

       910        920        930        940        950        960 
APHTQRELVG EWHHPYGREL AVFPTPQTRE NKYWPAVKRL DDVYGDRHLQ CSCPPLSDWA 

« Hide

References

[1]"Complete genome sequence of Edwardsiella ictaluri 93-146."
Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C., Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.
Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 93-146.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001600 Genomic DNA. Translation: ACR70489.1.
RefSeqYP_002934724.1. NC_012779.2.

3D structure databases

ProteinModelPortalC5BAT0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING634503.NT01EI_3351.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACR70489; ACR70489; NT01EI_3351.
GeneID7959651.
KEGGeic:NT01EI_3351.
PATRIC21839436. VBIEdwIct114273_2978.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAFDSRPYS.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycEICT634503:GCMY-3323-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_EDWI9
AccessionPrimary (citable) accession number: C5BAT0
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: May 14, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families