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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Edwardsiella ictaluri (strain 93-146)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciEICT634503:GCMY-3323-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:NT01EI_3351
OrganismiEdwardsiella ictaluri (strain 93-146)
Taxonomic identifieri634503 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEdwardsiella
ProteomesiUP000001485 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 960960Glycine dehydrogenase (decarboxylating)PRO_1000212654Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei709 – 7091N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi634503.NT01EI_3351.

Structurei

3D structure databases

ProteinModelPortaliC5BAT0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiRAESEMT.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

C5BAT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQTLTQLEN SDAFIARHIG PTPEEQQQML AQIGAADLDT LLARIVPADI
60 70 80 90 100
QLPAAPPIGA ACSEQQALDE LRAIAAQNQC YRSFIGMGYY GVQTPPAIQR
110 120 130 140 150
NMLENPGWYT AYTPYQPEVS QGRLEALLNF QQMTLDLTGL DLASASLLDE
160 170 180 190 200
ATAAAEAMGL ARRASRLKQA NTFFIAQDVH PQTIDVVCTR AQSCGVEVII
210 220 230 240 250
DDARRAADHR DLFGVLLQQV GTQGDLHDYR ALMDSLRERG VITCMAADPL
260 270 280 290 300
ALVLLEAPGR QGADVVFGSA QRFGVPMGYG GPHAAFFACR EAFKRAMPGR
310 320 330 340 350
IIGVARDAAG EPALRMAMQT REQHIRREKA NSNICTSQVL LANIAGMYAV
360 370 380 390 400
YHGPQGLRRI AERVHRLADI LALGLQQKGV TLRNHCWFDT LTVAVPDKGA
410 420 430 440 450
VLARALGFGI NLRGDLDGAV GISFDECSTR DDLEALFTIL LGDGHALDID
460 470 480 490 500
TLDTLVQEAC EGSIPAALLR REPILTHPVF NRYHSETALM RYMHALERRD
510 520 530 540 550
LALNQAMIPL GSCTMKLNAA AEMIPITWPE FAALHPFCPP EQAQGYRLLL
560 570 580 590 600
SQLAEWLVQL TGYDAVCLQP NSGAQGEYAG LLAIRRYHES RGEGQRTRCL
610 620 630 640 650
IPASAHGTNP ASAQMAGMEV EVVACDEQGN IDLHDLRERA RQAGERLAAI
660 670 680 690 700
MVTYPSTHGV YEETIREVCQ IVHQYGGQVY LDGANMNAQV GITTPGYIGA
710 720 730 740 750
DVSHLNLHKT FAIPHGGGGP GMGPIGVKAH LAPFVPGHRV VQLAGLTTRQ
760 770 780 790 800
GAVSAAPFGS ASILPISWMY IRMMGAEGLR RASTVAILNA NYIARRLGAV
810 820 830 840 850
YPVLYRGKEG YVAHECILDL RPLKARSGIS EMDIAKRLID YGFHAPTMSF
860 870 880 890 900
PVAGTLMVEP TESENKAELD RFIAAMLAIH DEITRVETGE WPLQDNPLVN
910 920 930 940 950
APHTQRELVG EWHHPYGREL AVFPTPQTRE NKYWPAVKRL DDVYGDRHLQ
960
CSCPPLSDWA
Length:960
Mass (Da):104,902
Last modified:July 28, 2009 - v1
Checksum:iC429F74ED788B891
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001600 Genomic DNA. Translation: ACR70489.1.
RefSeqiWP_015872563.1. NC_012779.2.
YP_002934724.1. NC_012779.2.

Genome annotation databases

EnsemblBacteriaiACR70489; ACR70489; NT01EI_3351.
GeneIDi7959651.
KEGGieic:NT01EI_3351.
PATRICi21839436. VBIEdwIct114273_2978.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001600 Genomic DNA. Translation: ACR70489.1.
RefSeqiWP_015872563.1. NC_012779.2.
YP_002934724.1. NC_012779.2.

3D structure databases

ProteinModelPortaliC5BAT0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi634503.NT01EI_3351.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACR70489; ACR70489; NT01EI_3351.
GeneIDi7959651.
KEGGieic:NT01EI_3351.
PATRICi21839436. VBIEdwIct114273_2978.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiRAESEMT.
OrthoDBiEOG6HMXDX.

Enzyme and pathway databases

BioCyciEICT634503:GCMY-3323-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Edwardsiella ictaluri 93-146."
    Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C., Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.
    Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 93-146.

Entry informationi

Entry nameiGCSP_EDWI9
AccessioniPrimary (citable) accession number: C5BAT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: May 27, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.