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C5BAT0

- GCSP_EDWI9

UniProt

C5BAT0 - GCSP_EDWI9

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, NT01EI_3351
Organism
Edwardsiella ictaluri (strain 93-146)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciEICT634503:GCMY-3323-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:NT01EI_3351
OrganismiEdwardsiella ictaluri (strain 93-146)
Taxonomic identifieri634503 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEdwardsiella
ProteomesiUP000001485: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 960960Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000212654Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei709 – 7091N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi634503.NT01EI_3351.

Structurei

3D structure databases

ProteinModelPortaliC5BAT0.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

C5BAT0-1 [UniParc]FASTAAdd to Basket

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MTQTLTQLEN SDAFIARHIG PTPEEQQQML AQIGAADLDT LLARIVPADI    50
QLPAAPPIGA ACSEQQALDE LRAIAAQNQC YRSFIGMGYY GVQTPPAIQR 100
NMLENPGWYT AYTPYQPEVS QGRLEALLNF QQMTLDLTGL DLASASLLDE 150
ATAAAEAMGL ARRASRLKQA NTFFIAQDVH PQTIDVVCTR AQSCGVEVII 200
DDARRAADHR DLFGVLLQQV GTQGDLHDYR ALMDSLRERG VITCMAADPL 250
ALVLLEAPGR QGADVVFGSA QRFGVPMGYG GPHAAFFACR EAFKRAMPGR 300
IIGVARDAAG EPALRMAMQT REQHIRREKA NSNICTSQVL LANIAGMYAV 350
YHGPQGLRRI AERVHRLADI LALGLQQKGV TLRNHCWFDT LTVAVPDKGA 400
VLARALGFGI NLRGDLDGAV GISFDECSTR DDLEALFTIL LGDGHALDID 450
TLDTLVQEAC EGSIPAALLR REPILTHPVF NRYHSETALM RYMHALERRD 500
LALNQAMIPL GSCTMKLNAA AEMIPITWPE FAALHPFCPP EQAQGYRLLL 550
SQLAEWLVQL TGYDAVCLQP NSGAQGEYAG LLAIRRYHES RGEGQRTRCL 600
IPASAHGTNP ASAQMAGMEV EVVACDEQGN IDLHDLRERA RQAGERLAAI 650
MVTYPSTHGV YEETIREVCQ IVHQYGGQVY LDGANMNAQV GITTPGYIGA 700
DVSHLNLHKT FAIPHGGGGP GMGPIGVKAH LAPFVPGHRV VQLAGLTTRQ 750
GAVSAAPFGS ASILPISWMY IRMMGAEGLR RASTVAILNA NYIARRLGAV 800
YPVLYRGKEG YVAHECILDL RPLKARSGIS EMDIAKRLID YGFHAPTMSF 850
PVAGTLMVEP TESENKAELD RFIAAMLAIH DEITRVETGE WPLQDNPLVN 900
APHTQRELVG EWHHPYGREL AVFPTPQTRE NKYWPAVKRL DDVYGDRHLQ 950
CSCPPLSDWA 960
Length:960
Mass (Da):104,902
Last modified:July 28, 2009 - v1
Checksum:iC429F74ED788B891
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001600 Genomic DNA. Translation: ACR70489.1.
RefSeqiYP_002934724.1. NC_012779.2.

Genome annotation databases

EnsemblBacteriaiACR70489; ACR70489; NT01EI_3351.
GeneIDi7959651.
KEGGieic:NT01EI_3351.
PATRICi21839436. VBIEdwIct114273_2978.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001600 Genomic DNA. Translation: ACR70489.1 .
RefSeqi YP_002934724.1. NC_012779.2.

3D structure databases

ProteinModelPortali C5BAT0.
ModBasei Search...

Protein-protein interaction databases

STRINGi 634503.NT01EI_3351.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACR70489 ; ACR70489 ; NT01EI_3351 .
GeneIDi 7959651.
KEGGi eic:NT01EI_3351.
PATRICi 21839436. VBIEdwIct114273_2978.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci EICT634503:GCMY-3323-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Edwardsiella ictaluri 93-146."
    Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C., Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.
    Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 93-146.

Entry informationi

Entry nameiGCSP_EDWI9
AccessioniPrimary (citable) accession number: C5BAT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: May 14, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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