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C5B8I4

- NUOCD_EDWI9

UniProt

C5B8I4 - NUOCD_EDWI9

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Protein
NADH-quinone oxidoreductase subunit C/D
Gene
nuoC, nuoCD, nuoD, NT01EI_2677
Organism
Edwardsiella ictaluri (strain 93-146)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.UniRule annotation

Catalytic activityi

NADH + quinone = NAD+ + quinol.UniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. NADH dehydrogenase (ubiquinone) activity Source: InterPro
  3. quinone binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Transport

Keywords - Ligandi

NAD, Ubiquinone

Enzyme and pathway databases

BioCyciEICT634503:GCMY-2653-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit C/D (EC:1.6.99.5)
Alternative name(s):
NADH dehydrogenase I subunit C/D
NDH-1 subunit C/D
Gene namesi
Name:nuoC
Synonyms:nuoCD, nuoD
Ordered Locus Names:NT01EI_2677
OrganismiEdwardsiella ictaluri (strain 93-146)
Taxonomic identifieri634503 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEdwardsiella
ProteomesiUP000001485: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. NADH dehydrogenase complex Source: InterPro
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 598598NADH-quinone oxidoreductase subunit C/DUniRule annotation
PRO_1000214870Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 13 different subunits. Subunits NuoB, CD, E, F, and G constitute the peripheral sector of the complex By similarity.

Protein-protein interaction databases

STRINGi634503.NT01EI_2677.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 189189NADH dehydrogenase I subunit C By similarity
Add
BLAST
Regioni213 – 598386NADH dehydrogenase I subunit D By similarity
Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the complex I 30 kDa subunit family.
In the C-terminal section; belongs to the complex I 49 kDa subunit family.

Phylogenomic databases

eggNOGiCOG0649.
HOGENOMiHOG000228264.
KOiK13378.
OMAiLAFTDRQ.
OrthoDBiEOG62G5MP.

Family and domain databases

Gene3Di1.10.645.10. 2 hits.
HAMAPiMF_01357. NDH1_NuoC.
MF_01358. NDH1_NuoD.
MF_01359. NDH1_NuoCD_1.
InterProiIPR010218. NADH_DH_suC.
IPR023062. NADH_DH_suCD.
IPR001135. NADH_Q_OxRdtase_suD.
IPR001268. NADH_UbQ_OxRdtase_30kDa_su.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR022885. NDH1_su_D/H.
IPR029014. NiFe_Hase-like.
[Graphical view]
PfamiPF00329. Complex1_30kDa. 1 hit.
PF00346. Complex1_49kDa. 1 hit.
[Graphical view]
ProDomiPD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF56762. SSF56762. 1 hit.
TIGRFAMsiTIGR01961. NuoC_fam. 1 hit.
TIGR01962. NuoD. 1 hit.
PROSITEiPS00535. COMPLEX1_49K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5B8I4-1 [UniParc]FASTAAdd to Basket

« Hide

MTDSTTHDRE MSAWQTHDHL DDPVIGELRN RFGPEAFSVQ PTRTGMPVVW    50
VKREQLLEVM AFLRQLPKPY VMLFDLHGMD ERLRTHRQGL PAADFSVFYH 100
LISIDRNRDI MLKVALAEQD LHLPTVTRLF PNANWYERET FDLFGITFDG 150
HPHLTRLLMP RTWQGHPLRK DYPARATEFD PFELTRQKQD LEMESLKFRP 200
EEWGMQRGTA NEDFMFLNLG PNHPSSHGAF RIVLQLDGED IVDCVPDIGY 250
HHRGAEKMGE RQSWHSYIPY TDRIEYLGGC VNEMPYVLAV EKLAGIEVPE 300
RVKVIRVMLS ELFRINSHLL YISTFIQDVG AMTPVFFAFT DRQKIYDIVE 350
AVTGFRMHPA WFRIGGVAHD LPKGWDRLLR EFLEWMPKRL DSYVKAALHN 400
SILKGRSIGV AAYGAKDALA WGTTGAGLRA TGIAFDVRKW RPYSGYENFE 450
FEVPTASNGD CYDRVMLKVE EIRQSLRILQ QCLKNMPEGP FKADHPLTTP 500
PPKERTLQHI DTLINHFLQV SWGPVMPANE SFQMVEATKG INSYYLTSDG 550
GTMSYRTRIR TPSYAHLQQI PSVIRGCLVS DLIVYLGSID FVMSDVDR 598
Length:598
Mass (Da):68,866
Last modified:July 28, 2009 - v1
Checksum:i117C5648EB6E95AD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001600 Genomic DNA. Translation: ACR69845.1.
RefSeqiYP_002934080.1. NC_012779.2.

Genome annotation databases

EnsemblBacteriaiACR69845; ACR69845; NT01EI_2677.
GeneIDi7961703.
KEGGieic:NT01EI_2677.
PATRICi21838214. VBIEdwIct114273_2392.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001600 Genomic DNA. Translation: ACR69845.1 .
RefSeqi YP_002934080.1. NC_012779.2.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 634503.NT01EI_2677.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACR69845 ; ACR69845 ; NT01EI_2677 .
GeneIDi 7961703.
KEGGi eic:NT01EI_2677.
PATRICi 21838214. VBIEdwIct114273_2392.

Phylogenomic databases

eggNOGi COG0649.
HOGENOMi HOG000228264.
KOi K13378.
OMAi LAFTDRQ.
OrthoDBi EOG62G5MP.

Enzyme and pathway databases

BioCyci EICT634503:GCMY-2653-MONOMER.

Family and domain databases

Gene3Di 1.10.645.10. 2 hits.
HAMAPi MF_01357. NDH1_NuoC.
MF_01358. NDH1_NuoD.
MF_01359. NDH1_NuoCD_1.
InterProi IPR010218. NADH_DH_suC.
IPR023062. NADH_DH_suCD.
IPR001135. NADH_Q_OxRdtase_suD.
IPR001268. NADH_UbQ_OxRdtase_30kDa_su.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR022885. NDH1_su_D/H.
IPR029014. NiFe_Hase-like.
[Graphical view ]
Pfami PF00329. Complex1_30kDa. 1 hit.
PF00346. Complex1_49kDa. 1 hit.
[Graphical view ]
ProDomi PD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF56762. SSF56762. 1 hit.
TIGRFAMsi TIGR01961. NuoC_fam. 1 hit.
TIGR01962. NuoD. 1 hit.
PROSITEi PS00535. COMPLEX1_49K. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Edwardsiella ictaluri 93-146."
    Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C., Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.
    Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 93-146.

Entry informationi

Entry nameiNUOCD_EDWI9
AccessioniPrimary (citable) accession number: C5B8I4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: June 11, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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