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C5B8I4 (NUOCD_EDWI9) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-quinone oxidoreductase subunit C/D

EC=1.6.99.5
Alternative name(s):
NADH dehydrogenase I subunit C/D
NDH-1 subunit C/D
Gene names
Name:nuoC
Synonyms:nuoCD, nuoD
Ordered Locus Names:NT01EI_2677
OrganismEdwardsiella ictaluri (strain 93-146) [Complete proteome] [HAMAP]
Taxonomic identifier634503 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEdwardsiella

Protein attributes

Sequence length598 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity. HAMAP-Rule MF_01359

Catalytic activity

NADH + quinone = NAD+ + quinol. HAMAP-Rule MF_01359

Subunit structure

NDH-1 is composed of 13 different subunits. Subunits NuoB, CD, E, F, and G constitute the peripheral sector of the complex By similarity.

Subcellular location

Cell inner membrane; Peripheral membrane protein; Cytoplasmic side By similarity HAMAP-Rule MF_01359.

Sequence similarities

In the N-terminal section; belongs to the complex I 30 kDa subunit family.

In the C-terminal section; belongs to the complex I 49 kDa subunit family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   LigandNAD
Ubiquinone
   Molecular functionOxidoreductase
   PTMQuinone
   Technical termComplete proteome
Multifunctional enzyme
Gene Ontology (GO)
   Biological_processtransport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentNADH dehydrogenase complex

Inferred from electronic annotation. Source: InterPro

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

NADH dehydrogenase (ubiquinone) activity

Inferred from electronic annotation. Source: InterPro

quinone binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 598598NADH-quinone oxidoreductase subunit C/D HAMAP-Rule MF_01359
PRO_1000214870

Regions

Region1 – 189189NADH dehydrogenase I subunit C By similarity
Region213 – 598386NADH dehydrogenase I subunit D By similarity

Sequences

Sequence LengthMass (Da)Tools
C5B8I4 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 117C5648EB6E95AD

FASTA59868,866
        10         20         30         40         50         60 
MTDSTTHDRE MSAWQTHDHL DDPVIGELRN RFGPEAFSVQ PTRTGMPVVW VKREQLLEVM 

        70         80         90        100        110        120 
AFLRQLPKPY VMLFDLHGMD ERLRTHRQGL PAADFSVFYH LISIDRNRDI MLKVALAEQD 

       130        140        150        160        170        180 
LHLPTVTRLF PNANWYERET FDLFGITFDG HPHLTRLLMP RTWQGHPLRK DYPARATEFD 

       190        200        210        220        230        240 
PFELTRQKQD LEMESLKFRP EEWGMQRGTA NEDFMFLNLG PNHPSSHGAF RIVLQLDGED 

       250        260        270        280        290        300 
IVDCVPDIGY HHRGAEKMGE RQSWHSYIPY TDRIEYLGGC VNEMPYVLAV EKLAGIEVPE 

       310        320        330        340        350        360 
RVKVIRVMLS ELFRINSHLL YISTFIQDVG AMTPVFFAFT DRQKIYDIVE AVTGFRMHPA 

       370        380        390        400        410        420 
WFRIGGVAHD LPKGWDRLLR EFLEWMPKRL DSYVKAALHN SILKGRSIGV AAYGAKDALA 

       430        440        450        460        470        480 
WGTTGAGLRA TGIAFDVRKW RPYSGYENFE FEVPTASNGD CYDRVMLKVE EIRQSLRILQ 

       490        500        510        520        530        540 
QCLKNMPEGP FKADHPLTTP PPKERTLQHI DTLINHFLQV SWGPVMPANE SFQMVEATKG 

       550        560        570        580        590 
INSYYLTSDG GTMSYRTRIR TPSYAHLQQI PSVIRGCLVS DLIVYLGSID FVMSDVDR 

« Hide

References

[1]"Complete genome sequence of Edwardsiella ictaluri 93-146."
Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C., Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.
Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 93-146.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001600 Genomic DNA. Translation: ACR69845.1.
RefSeqYP_002934080.1. NC_012779.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING634503.NT01EI_2677.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACR69845; ACR69845; NT01EI_2677.
GeneID7961703.
KEGGeic:NT01EI_2677.
PATRIC21838214. VBIEdwIct114273_2392.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0649.
HOGENOMHOG000228264.
KOK13378.
OMAPVFYMFT.
OrthoDBEOG62G5MP.
ProtClustDBPRK11742.

Enzyme and pathway databases

BioCycEICT634503:GCMY-2653-MONOMER.

Family and domain databases

HAMAPMF_01357. NDH1_NuoC.
MF_01358. NDH1_NuoD.
MF_01359. NDH1_NuoCD_1.
InterProIPR010218. NADH_DH_suC.
IPR023062. NADH_DH_suCD.
IPR001135. NADH_Q_OxRdtase_suD.
IPR001268. NADH_UbQ_OxRdtase_30kDa_su.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR022885. NDH1_su_D/H.
[Graphical view]
PfamPF00329. Complex1_30kDa. 1 hit.
PF00346. Complex1_49kDa. 1 hit.
[Graphical view]
ProDomPD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR01961. NuoC_fam. 1 hit.
TIGR01962. NuoD. 1 hit.
PROSITEPS00535. COMPLEX1_49K. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNUOCD_EDWI9
AccessionPrimary (citable) accession number: C5B8I4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: February 19, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families