Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

C5B8I4

- NUOCD_EDWI9

UniProt

C5B8I4 - NUOCD_EDWI9

Protein

NADH-quinone oxidoreductase subunit C/D

Gene

nuoC

Organism
Edwardsiella ictaluri (strain 93-146)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

    Catalytic activityi

    NADH + quinone = NAD+ + quinol.UniRule annotation

    GO - Molecular functioni

    1. NAD binding Source: InterPro
    2. NADH dehydrogenase (ubiquinone) activity Source: InterPro
    3. quinone binding Source: UniProtKB-KW

    GO - Biological processi

    1. transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Enzyme and pathway databases

    BioCyciEICT634503:GCMY-2653-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-quinone oxidoreductase subunit C/DUniRule annotation (EC:1.6.99.5UniRule annotation)
    Alternative name(s):
    NADH dehydrogenase I subunit C/DUniRule annotation
    NDH-1 subunit C/DUniRule annotation
    Gene namesi
    Name:nuoCUniRule annotation
    Synonyms:nuoCDUniRule annotation, nuoDUniRule annotation
    Ordered Locus Names:NT01EI_2677
    OrganismiEdwardsiella ictaluri (strain 93-146)
    Taxonomic identifieri634503 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEdwardsiella
    ProteomesiUP000001485: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

    GO - Cellular componenti

    1. NADH dehydrogenase complex Source: InterPro
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 598598NADH-quinone oxidoreductase subunit C/DPRO_1000214870Add
    BLAST

    Keywords - PTMi

    Quinone

    Interactioni

    Subunit structurei

    NDH-1 is composed of 13 different subunits. Subunits NuoB, CD, E, F, and G constitute the peripheral sector of the complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi634503.NT01EI_2677.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 189189NADH dehydrogenase I subunit CUniRule annotationAdd
    BLAST
    Regioni213 – 598386NADH dehydrogenase I subunit DUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the complex I 30 kDa subunit family.UniRule annotation
    In the C-terminal section; belongs to the complex I 49 kDa subunit family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0649.
    HOGENOMiHOG000228264.
    KOiK13378.
    OMAiLAFTDRQ.
    OrthoDBiEOG62G5MP.

    Family and domain databases

    Gene3Di1.10.645.10. 2 hits.
    HAMAPiMF_01357. NDH1_NuoC.
    MF_01358. NDH1_NuoD.
    MF_01359. NDH1_NuoCD_1.
    InterProiIPR010218. NADH_DH_suC.
    IPR023062. NADH_DH_suCD.
    IPR001135. NADH_Q_OxRdtase_suD.
    IPR001268. NADH_UbQ_OxRdtase_30kDa_su.
    IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
    IPR022885. NDH1_su_D/H.
    IPR029014. NiFe_Hase-like.
    [Graphical view]
    PfamiPF00329. Complex1_30kDa. 1 hit.
    PF00346. Complex1_49kDa. 1 hit.
    [Graphical view]
    ProDomiPD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF56762. SSF56762. 1 hit.
    TIGRFAMsiTIGR01961. NuoC_fam. 1 hit.
    TIGR01962. NuoD. 1 hit.
    PROSITEiPS00535. COMPLEX1_49K. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C5B8I4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDSTTHDRE MSAWQTHDHL DDPVIGELRN RFGPEAFSVQ PTRTGMPVVW    50
    VKREQLLEVM AFLRQLPKPY VMLFDLHGMD ERLRTHRQGL PAADFSVFYH 100
    LISIDRNRDI MLKVALAEQD LHLPTVTRLF PNANWYERET FDLFGITFDG 150
    HPHLTRLLMP RTWQGHPLRK DYPARATEFD PFELTRQKQD LEMESLKFRP 200
    EEWGMQRGTA NEDFMFLNLG PNHPSSHGAF RIVLQLDGED IVDCVPDIGY 250
    HHRGAEKMGE RQSWHSYIPY TDRIEYLGGC VNEMPYVLAV EKLAGIEVPE 300
    RVKVIRVMLS ELFRINSHLL YISTFIQDVG AMTPVFFAFT DRQKIYDIVE 350
    AVTGFRMHPA WFRIGGVAHD LPKGWDRLLR EFLEWMPKRL DSYVKAALHN 400
    SILKGRSIGV AAYGAKDALA WGTTGAGLRA TGIAFDVRKW RPYSGYENFE 450
    FEVPTASNGD CYDRVMLKVE EIRQSLRILQ QCLKNMPEGP FKADHPLTTP 500
    PPKERTLQHI DTLINHFLQV SWGPVMPANE SFQMVEATKG INSYYLTSDG 550
    GTMSYRTRIR TPSYAHLQQI PSVIRGCLVS DLIVYLGSID FVMSDVDR 598
    Length:598
    Mass (Da):68,866
    Last modified:July 28, 2009 - v1
    Checksum:i117C5648EB6E95AD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001600 Genomic DNA. Translation: ACR69845.1.
    RefSeqiYP_002934080.1. NC_012779.2.

    Genome annotation databases

    EnsemblBacteriaiACR69845; ACR69845; NT01EI_2677.
    GeneIDi7961703.
    KEGGieic:NT01EI_2677.
    PATRICi21838214. VBIEdwIct114273_2392.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001600 Genomic DNA. Translation: ACR69845.1 .
    RefSeqi YP_002934080.1. NC_012779.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 634503.NT01EI_2677.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACR69845 ; ACR69845 ; NT01EI_2677 .
    GeneIDi 7961703.
    KEGGi eic:NT01EI_2677.
    PATRICi 21838214. VBIEdwIct114273_2392.

    Phylogenomic databases

    eggNOGi COG0649.
    HOGENOMi HOG000228264.
    KOi K13378.
    OMAi LAFTDRQ.
    OrthoDBi EOG62G5MP.

    Enzyme and pathway databases

    BioCyci EICT634503:GCMY-2653-MONOMER.

    Family and domain databases

    Gene3Di 1.10.645.10. 2 hits.
    HAMAPi MF_01357. NDH1_NuoC.
    MF_01358. NDH1_NuoD.
    MF_01359. NDH1_NuoCD_1.
    InterProi IPR010218. NADH_DH_suC.
    IPR023062. NADH_DH_suCD.
    IPR001135. NADH_Q_OxRdtase_suD.
    IPR001268. NADH_UbQ_OxRdtase_30kDa_su.
    IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
    IPR022885. NDH1_su_D/H.
    IPR029014. NiFe_Hase-like.
    [Graphical view ]
    Pfami PF00329. Complex1_30kDa. 1 hit.
    PF00346. Complex1_49kDa. 1 hit.
    [Graphical view ]
    ProDomi PD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF56762. SSF56762. 1 hit.
    TIGRFAMsi TIGR01961. NuoC_fam. 1 hit.
    TIGR01962. NuoD. 1 hit.
    PROSITEi PS00535. COMPLEX1_49K. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Edwardsiella ictaluri 93-146."
      Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C., Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.
      Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 93-146.

    Entry informationi

    Entry nameiNUOCD_EDWI9
    AccessioniPrimary (citable) accession number: C5B8I4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3