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Protein

NADH-quinone oxidoreductase subunit C/D

Gene

nuoC

Organism
Edwardsiella ictaluri (strain 93-146)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

Catalytic activityi

NADH + quinone = NAD+ + quinol.UniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. NADH dehydrogenase (ubiquinone) activity Source: InterPro
  3. quinone binding Source: UniProtKB-KW

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Transport

Keywords - Ligandi

NAD, Ubiquinone

Enzyme and pathway databases

BioCyciEICT634503:GCMY-2653-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit C/DUniRule annotation (EC:1.6.99.5UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit C/DUniRule annotation
NDH-1 subunit C/DUniRule annotation
Gene namesi
Name:nuoCUniRule annotation
Synonyms:nuoCDUniRule annotation, nuoDUniRule annotation
Ordered Locus Names:NT01EI_2677
OrganismiEdwardsiella ictaluri (strain 93-146)
Taxonomic identifieri634503 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEdwardsiella
ProteomesiUP000001485: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

  1. NADH dehydrogenase complex Source: InterPro
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 598598NADH-quinone oxidoreductase subunit C/DPRO_1000214870Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 13 different subunits. Subunits NuoB, CD, E, F, and G constitute the peripheral sector of the complex.UniRule annotation

Protein-protein interaction databases

STRINGi634503.NT01EI_2677.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 189189NADH dehydrogenase I subunit CUniRule annotationAdd
BLAST
Regioni213 – 598386NADH dehydrogenase I subunit DUniRule annotationAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the complex I 30 kDa subunit family.UniRule annotation
In the C-terminal section; belongs to the complex I 49 kDa subunit family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0649.
HOGENOMiHOG000228264.
KOiK13378.
OMAiCYSRVML.
OrthoDBiEOG62G5MP.

Family and domain databases

Gene3Di1.10.645.10. 2 hits.
HAMAPiMF_01357. NDH1_NuoC.
MF_01358. NDH1_NuoD.
MF_01359. NDH1_NuoCD_1.
InterProiIPR010218. NADH_DH_suC.
IPR023062. NADH_DH_suCD.
IPR001135. NADH_Q_OxRdtase_suD.
IPR001268. NADH_UbQ_OxRdtase_30kDa_su.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR022885. NDH1_su_D/H.
IPR029014. NiFe_Hase-like.
[Graphical view]
PfamiPF00329. Complex1_30kDa. 1 hit.
PF00346. Complex1_49kDa. 1 hit.
[Graphical view]
ProDomiPD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF56762. SSF56762. 1 hit.
TIGRFAMsiTIGR01961. NuoC_fam. 1 hit.
TIGR01962. NuoD. 1 hit.
PROSITEiPS00535. COMPLEX1_49K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5B8I4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDSTTHDRE MSAWQTHDHL DDPVIGELRN RFGPEAFSVQ PTRTGMPVVW
60 70 80 90 100
VKREQLLEVM AFLRQLPKPY VMLFDLHGMD ERLRTHRQGL PAADFSVFYH
110 120 130 140 150
LISIDRNRDI MLKVALAEQD LHLPTVTRLF PNANWYERET FDLFGITFDG
160 170 180 190 200
HPHLTRLLMP RTWQGHPLRK DYPARATEFD PFELTRQKQD LEMESLKFRP
210 220 230 240 250
EEWGMQRGTA NEDFMFLNLG PNHPSSHGAF RIVLQLDGED IVDCVPDIGY
260 270 280 290 300
HHRGAEKMGE RQSWHSYIPY TDRIEYLGGC VNEMPYVLAV EKLAGIEVPE
310 320 330 340 350
RVKVIRVMLS ELFRINSHLL YISTFIQDVG AMTPVFFAFT DRQKIYDIVE
360 370 380 390 400
AVTGFRMHPA WFRIGGVAHD LPKGWDRLLR EFLEWMPKRL DSYVKAALHN
410 420 430 440 450
SILKGRSIGV AAYGAKDALA WGTTGAGLRA TGIAFDVRKW RPYSGYENFE
460 470 480 490 500
FEVPTASNGD CYDRVMLKVE EIRQSLRILQ QCLKNMPEGP FKADHPLTTP
510 520 530 540 550
PPKERTLQHI DTLINHFLQV SWGPVMPANE SFQMVEATKG INSYYLTSDG
560 570 580 590
GTMSYRTRIR TPSYAHLQQI PSVIRGCLVS DLIVYLGSID FVMSDVDR
Length:598
Mass (Da):68,866
Last modified:July 28, 2009 - v1
Checksum:i117C5648EB6E95AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001600 Genomic DNA. Translation: ACR69845.1.
RefSeqiWP_015871950.1. NC_012779.2.
YP_002934080.1. NC_012779.2.

Genome annotation databases

EnsemblBacteriaiACR69845; ACR69845; NT01EI_2677.
GeneIDi7961703.
KEGGieic:NT01EI_2677.
PATRICi21838214. VBIEdwIct114273_2392.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001600 Genomic DNA. Translation: ACR69845.1.
RefSeqiWP_015871950.1. NC_012779.2.
YP_002934080.1. NC_012779.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi634503.NT01EI_2677.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACR69845; ACR69845; NT01EI_2677.
GeneIDi7961703.
KEGGieic:NT01EI_2677.
PATRICi21838214. VBIEdwIct114273_2392.

Phylogenomic databases

eggNOGiCOG0649.
HOGENOMiHOG000228264.
KOiK13378.
OMAiCYSRVML.
OrthoDBiEOG62G5MP.

Enzyme and pathway databases

BioCyciEICT634503:GCMY-2653-MONOMER.

Family and domain databases

Gene3Di1.10.645.10. 2 hits.
HAMAPiMF_01357. NDH1_NuoC.
MF_01358. NDH1_NuoD.
MF_01359. NDH1_NuoCD_1.
InterProiIPR010218. NADH_DH_suC.
IPR023062. NADH_DH_suCD.
IPR001135. NADH_Q_OxRdtase_suD.
IPR001268. NADH_UbQ_OxRdtase_30kDa_su.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR022885. NDH1_su_D/H.
IPR029014. NiFe_Hase-like.
[Graphical view]
PfamiPF00329. Complex1_30kDa. 1 hit.
PF00346. Complex1_49kDa. 1 hit.
[Graphical view]
ProDomiPD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF56762. SSF56762. 1 hit.
TIGRFAMsiTIGR01961. NuoC_fam. 1 hit.
TIGR01962. NuoD. 1 hit.
PROSITEiPS00535. COMPLEX1_49K. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Edwardsiella ictaluri 93-146."
    Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C., Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.
    Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 93-146.

Entry informationi

Entry nameiNUOCD_EDWI9
AccessioniPrimary (citable) accession number: C5B8I4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: March 4, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.