ID G6PI_EDWI9 Reviewed; 549 AA. AC C5B6Z1; DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot. DT 28-JUL-2009, sequence version 1. DT 27-MAR-2024, entry version 83. DE RecName: Full=Glucose-6-phosphate isomerase {ECO:0000255|HAMAP-Rule:MF_00473}; DE Short=GPI {ECO:0000255|HAMAP-Rule:MF_00473}; DE EC=5.3.1.9 {ECO:0000255|HAMAP-Rule:MF_00473}; DE AltName: Full=Phosphoglucose isomerase {ECO:0000255|HAMAP-Rule:MF_00473}; DE Short=PGI {ECO:0000255|HAMAP-Rule:MF_00473}; DE AltName: Full=Phosphohexose isomerase {ECO:0000255|HAMAP-Rule:MF_00473}; DE Short=PHI {ECO:0000255|HAMAP-Rule:MF_00473}; GN Name=pgi {ECO:0000255|HAMAP-Rule:MF_00473}; GN OrderedLocusNames=NT01EI_0210; OS Edwardsiella ictaluri (strain 93-146). OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; OC Hafniaceae; Edwardsiella. OX NCBI_TaxID=634503; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=93-146; RA Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C., RA Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.; RT "Complete genome sequence of Edwardsiella ictaluri 93-146."; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes the reversible isomerization of glucose-6-phosphate CC to fructose-6-phosphate. {ECO:0000255|HAMAP-Rule:MF_00473}. CC -!- CATALYTIC ACTIVITY: CC Reaction=alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate; CC Xref=Rhea:RHEA:11816, ChEBI:CHEBI:57634, ChEBI:CHEBI:58225; CC EC=5.3.1.9; Evidence={ECO:0000255|HAMAP-Rule:MF_00473}; CC -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis. CC {ECO:0000255|HAMAP-Rule:MF_00473}. CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- CC phosphate and glycerone phosphate from D-glucose: step 2/4. CC {ECO:0000255|HAMAP-Rule:MF_00473}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00473}. CC -!- SIMILARITY: Belongs to the GPI family. {ECO:0000255|HAMAP- CC Rule:MF_00473}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP001600; ACR67453.1; -; Genomic_DNA. DR RefSeq; WP_015869663.1; NC_012779.2. DR AlphaFoldDB; C5B6Z1; -. DR SMR; C5B6Z1; -. DR STRING; 67780.B6E78_12190; -. DR GeneID; 69537314; -. DR KEGG; eic:NT01EI_0210; -. DR PATRIC; fig|634503.3.peg.186; -. DR HOGENOM; CLU_017947_3_1_6; -. DR OrthoDB; 140919at2; -. DR UniPathway; UPA00109; UER00181. DR UniPathway; UPA00138; -. DR Proteomes; UP000001485; Chromosome. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro. DR GO; GO:0004347; F:glucose-6-phosphate isomerase activity; IEA:UniProtKB-UniRule. DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniRule. DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniRule. DR CDD; cd05015; SIS_PGI_1; 1. DR CDD; cd05016; SIS_PGI_2; 1. DR Gene3D; 1.10.1390.10; -; 1. DR HAMAP; MF_00473; G6P_isomerase; 1. DR InterPro; IPR001672; G6P_Isomerase. DR InterPro; IPR023096; G6P_Isomerase_C. DR InterPro; IPR018189; Phosphoglucose_isomerase_CS. DR InterPro; IPR046348; SIS_dom_sf. DR InterPro; IPR035476; SIS_PGI_1. DR InterPro; IPR035482; SIS_PGI_2. DR PANTHER; PTHR11469; GLUCOSE-6-PHOSPHATE ISOMERASE; 1. DR PANTHER; PTHR11469:SF1; GLUCOSE-6-PHOSPHATE ISOMERASE; 1. DR Pfam; PF00342; PGI; 1. DR PRINTS; PR00662; G6PISOMERASE. DR SUPFAM; SSF53697; SIS domain; 1. DR PROSITE; PS00765; P_GLUCOSE_ISOMERASE_1; 1. DR PROSITE; PS00174; P_GLUCOSE_ISOMERASE_2; 1. DR PROSITE; PS51463; P_GLUCOSE_ISOMERASE_3; 1. PE 3: Inferred from homology; KW Cytoplasm; Gluconeogenesis; Glycolysis; Isomerase. FT CHAIN 1..549 FT /note="Glucose-6-phosphate isomerase" FT /id="PRO_1000206365" FT ACT_SITE 355 FT /note="Proton donor" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00473" FT ACT_SITE 386 FT /evidence="ECO:0000255|HAMAP-Rule:MF_00473" FT ACT_SITE 514 FT /evidence="ECO:0000255|HAMAP-Rule:MF_00473" SQ SEQUENCE 549 AA; 61432 MW; 657972086A3D2C79 CRC64; MKNINPTRTA AWQALQQHFG QMKSVHMRDL FAADADRFSK FSATFDDQML VDYSKNRINA ETLEKLQALA RETDLQGAIA AMFAGEKINR TEDRAVLHIA LRNRSNTPIC VDGKDVMPEV NAVLAKMKQF CVRVIDGEWR GYTGKAITDV VNIGIGGSDL GPYMVTEALR PYKNHLTMHF VSNVDGTHIA ETLQRLNPET TLFLVASKTF TTQETMTNAH SARDWFLQAA GDERHVARHF AALSTNVQAV AAFGIDTANM FEFWDWVGGR YSLWSAIGLS IALSIGYDNF EQLLAGAHAM DRHFASAPLP QNLPVLLALI GIWYNNFFGA ETEAILPYDQ YMHRFPAYFQ QGNMESNGKY VDRDGQVVDY QTGPIIWGEP GTNGQHAFYQ LIHQGTKLIP CDFIAPAISH NPLGDHHGKL LSNFFAQTEA LAFGKSREAV EEEFAKAGKS AAEVQHIVPF KVFEGNRPTN SILLREITPY SLGMLIALYE HKIFTQGVIL NIFSFDQWGV ELGKQLANRI LPELEDAQPV RSHDSSTNAL INRFKAWRA //