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C5AZJ8

- C5AZJ8_METEA

UniProt

C5AZJ8 - C5AZJ8_METEA

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Methylobacterium extorquens (strain ATCC 14718 / DSM 1338 / AM1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei647 – 6471ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetaseUniRule annotationImported, Ligase

    Keywords - Biological processi

    Protein biosynthesisUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMEXT272630:GBY6-1410-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Gene namesi
    Name:leuSUniRule annotationImported
    Ordered Locus Names:MexAM1_META1p1470Imported
    OrganismiMethylobacterium extorquens (strain ATCC 14718 / DSM 1338 / AM1)Imported
    Taxonomic identifieri272630 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
    ProteomesiUP000009081: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi272630.MexAM1_META1p1470.

    Structurei

    3D structure databases

    ProteinModelPortaliC5AZJ8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi56 – 6611"HIGH" regionUniRule annotationAdd
    BLAST
    Motifi644 – 6485"KMSKS" regionUniRule annotation

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C5AZJ8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDSAQPSPT AQERHQERYN AKDAEPRWQQ AWDAAKLFET KNDDPRPKYY    50
    VLEMFPYPSG RIHIGHVRNY AMGDVVARYK RAKGHNVLHP MGWDAFGLPA 100
    ENAAMERKVN PREWTYANIA TMRGQLQSMG LSLDWSREIA TCDPDYYKHQ 150
    QRMFLDFLGK GLVTRRTAKV NWDPVDHTVL ANEQVIDGRG WRSGALVEQR 200
    ELTQWFFKIT DFAQDLHDAL DGLERWPEKV RLMQRNWIGR SEGLEVRFAL 250
    AAPFAGTDEV TVYTTRPDTL FGAKFLAISV DHPLARALAE SGPKAAELQA 300
    FAEECRRIGT AQEAIDTAEK LGFDTGLTVR HPLDPSWELP VFVANFVLME 350
    YGTGAVFGCP AHDQRDLDFA NKYGLGNTPV VCPEGQDPDA FIITDTAYDG 400
    DGRMIHSRFL DGMTTDEAFK AVADRLEGET LGDAPVARRK VQFRLRDWGV 450
    SRQRYWGCPI PIIHCEACGP VPVPVADLPV KLPDEVSFDQ PGNPLEREQA 500
    WRQVPCPRCG AAARRETDTM DTFVDSSWYY ARFTAPWLAD APTDRKTVDH 550
    WLAVDQYIGG VEHAILHLLY SRFFMRAMQA TGWSGVSEPF AGLFTQGMVV 600
    HETYKDAAGA WTPPAEIRFE TQDGARKAFH VKTGEPIEIG PTEKMSKSKK 650
    NVVDPDDIIA SYGADTARWF MLSDSPPERD VIWTEEGVQG AARFVQRVWR 700
    LVHGATAANG PGGTADAPLR KAAHKALAAV GEDIERLRFN RCVAHIYTLA 750
    NALDEGLRGG ASKAAAGEAA RILVQLIAPM MPHLAEESWR VLGGEGLVAE 800
    TAWPVADQAL LVEDEITLPV QINGKKRADV TVPRDADAKA VEAATLALEP 850
    VQRALEGRAP RKVIVVPGRI VNLVV 875
    Length:875
    Mass (Da):97,337
    Last modified:July 28, 2009 - v1
    Checksum:iBF494B79EA51E6F5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001510 Genomic DNA. Translation: ACS39332.1.
    RefSeqiYP_002962609.1. NC_012808.1.

    Genome annotation databases

    EnsemblBacteriaiACS39332; ACS39332; MexAM1_META1p1470.
    GeneIDi7991449.
    KEGGimea:Mex_1p1470.
    PATRICi22508779. VBIMetExt101010_1466.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001510 Genomic DNA. Translation: ACS39332.1 .
    RefSeqi YP_002962609.1. NC_012808.1.

    3D structure databases

    ProteinModelPortali C5AZJ8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272630.MexAM1_META1p1470.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACS39332 ; ACS39332 ; MexAM1_META1p1470 .
    GeneIDi 7991449.
    KEGGi mea:Mex_1p1470.
    PATRICi 22508779. VBIMetExt101010_1466.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci MEXT272630:GBY6-1410-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 14718 / DSM 1338 / AM1Imported.

    Entry informationi

    Entry nameiC5AZJ8_METEA
    AccessioniPrimary (citable) accession number: C5AZJ8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 28, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3