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C5AZJ8 (C5AZJ8_METEA) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein attributes

Sequence length875 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family. HAMAP-Rule MF_00049 RuleBase RU003489

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Motif56 – 6611"HIGH" region By similarity HAMAP-Rule MF_00049
Motif644 – 6485"KMSKS" region By similarity HAMAP-Rule MF_00049

Sites

Binding site6471ATP By similarity HAMAP-Rule MF_00049

Sequences

Sequence LengthMass (Da)Tools
C5AZJ8 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: BF494B79EA51E6F5

FASTA87597,337
        10         20         30         40         50         60 
MTDSAQPSPT AQERHQERYN AKDAEPRWQQ AWDAAKLFET KNDDPRPKYY VLEMFPYPSG 

        70         80         90        100        110        120 
RIHIGHVRNY AMGDVVARYK RAKGHNVLHP MGWDAFGLPA ENAAMERKVN PREWTYANIA 

       130        140        150        160        170        180 
TMRGQLQSMG LSLDWSREIA TCDPDYYKHQ QRMFLDFLGK GLVTRRTAKV NWDPVDHTVL 

       190        200        210        220        230        240 
ANEQVIDGRG WRSGALVEQR ELTQWFFKIT DFAQDLHDAL DGLERWPEKV RLMQRNWIGR 

       250        260        270        280        290        300 
SEGLEVRFAL AAPFAGTDEV TVYTTRPDTL FGAKFLAISV DHPLARALAE SGPKAAELQA 

       310        320        330        340        350        360 
FAEECRRIGT AQEAIDTAEK LGFDTGLTVR HPLDPSWELP VFVANFVLME YGTGAVFGCP 

       370        380        390        400        410        420 
AHDQRDLDFA NKYGLGNTPV VCPEGQDPDA FIITDTAYDG DGRMIHSRFL DGMTTDEAFK 

       430        440        450        460        470        480 
AVADRLEGET LGDAPVARRK VQFRLRDWGV SRQRYWGCPI PIIHCEACGP VPVPVADLPV 

       490        500        510        520        530        540 
KLPDEVSFDQ PGNPLEREQA WRQVPCPRCG AAARRETDTM DTFVDSSWYY ARFTAPWLAD 

       550        560        570        580        590        600 
APTDRKTVDH WLAVDQYIGG VEHAILHLLY SRFFMRAMQA TGWSGVSEPF AGLFTQGMVV 

       610        620        630        640        650        660 
HETYKDAAGA WTPPAEIRFE TQDGARKAFH VKTGEPIEIG PTEKMSKSKK NVVDPDDIIA 

       670        680        690        700        710        720 
SYGADTARWF MLSDSPPERD VIWTEEGVQG AARFVQRVWR LVHGATAANG PGGTADAPLR 

       730        740        750        760        770        780 
KAAHKALAAV GEDIERLRFN RCVAHIYTLA NALDEGLRGG ASKAAAGEAA RILVQLIAPM 

       790        800        810        820        830        840 
MPHLAEESWR VLGGEGLVAE TAWPVADQAL LVEDEITLPV QINGKKRADV TVPRDADAKA 

       850        860        870 
VEAATLALEP VQRALEGRAP RKVIVVPGRI VNLVV 

« Hide

References

[1]"Methylobacterium genome sequences: a reference blueprint to investigate microbial metabolism of C1 compounds from natural and industrial sources."
Vuilleumier S., Chistoserdova L., Lee M.-C., Bringel F., Lajus A., Zhou Y., Gourion B., Barbe V., Chang J., Cruveiller S., Dossat C., Gillett W., Gruffaz C., Haugen E., Hourcade E., Levy R., Mangenot S., Muller E. expand/collapse author list , Nadalig T., Pagni M., Penny C., Peyraud R., Robinson D.G., Roche D., Rouy Z., Saenampechek C., Salvignol G., Vallenet D., Wu Z., Marx C.J., Vorholt J.A., Olson M.V., Kaul R., Weissenbach J., Medigue C., Lidstrom M.E.
PLoS ONE 4:E5584-E5584(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 14718 / DSM 1338 / AM1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001510 Genomic DNA. Translation: ACS39332.1.
RefSeqYP_002962609.1. NC_012808.1.

3D structure databases

ProteinModelPortalC5AZJ8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272630.MexAM1_META1p1470.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACS39332; ACS39332; MexAM1_META1p1470.
GeneID7991449.
KEGGmea:Mex_1p1470.
PATRIC22508779. VBIMetExt101010_1466.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAHISHELW.
OrthoDBEOG63Z74X.

Enzyme and pathway databases

BioCycMEXT272630:GBY6-1410-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC5AZJ8_METEA
AccessionPrimary (citable) accession number: C5AZJ8
Entry history
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: July 9, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)